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Content Reviewed By:
Dr. Sanjay Mehta
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
Like all medicines, Moxclav DS 457mg Oral Suspension can cause side effects, although not everybody gets them. Common side effects include nausea, vomiting, diarrhea, stomach pain, loss of appetite, and skin rash. Less common side effects include indigestion, dizziness, headache, and oral thrush (a fungal infection in the mouth). Rare side effects include changes in blood counts, liver problems (indicated by jaundice or abnormal liver function tests), severe skin reactions (such as Stevens-Johnson syndrome or toxic epidermal necrolysis), allergic reactions (including swelling of the face, lips, tongue, or throat, difficulty breathing, and anaphylaxis), seizures (fits), and antibiotic-associated colitis (inflammation of the colon). If you experience any serious side effects, stop taking Moxclav DS and seek immediate medical attention.

General paediatric use
Use only on prescriptionMoxclav DS 457 syrup is a prescription‑only antibiotic and should not be used without a doctor’s evaluation and written instructions.
Moxclav DS 457mg Oral Suspension 30 ml is an antibiotic medicine used to treat bacterial infections. It contains amoxicillin and clavulanic acid.
This medicine is used to treat various bacterial infections like ear, nose, throat, skin, and urinary tract infections.
Amoxicillin prevents the formation of the bacterial cell wall, while clavulanic acid prevents amoxicillin from being inactivated.
The dosage depends on the severity of the infection and the child's weight. Follow the dosage prescribed by the doctor.
Common side effects may include diarrhea, vomiting, stomach pain, and skin rash.
It is recommended to take it with food to reduce the chance of stomach upset.
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
Store it at room temperature, away from direct sunlight and moisture. Keep out of reach of children.
Some medications can interact with Moxclav DS. Tell your doctor about all the medicines you are taking.
This medicine is safe when taken as prescribed by the doctor. If you experience any unusual side effects, contact your doctor.
If the child vomits within 30 minutes of taking the dose, give the dose again. If vomiting occurs after 30 minutes, do not repeat the dose.
No, Moxclav DS is an antibiotic and is not effective against viral infections like cold or flu.
Yes, probiotics can be given to help prevent diarrhea associated with antibiotics.
If you experience symptoms of an allergic reaction such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek immediate medical attention.
In some cases, Moxclav DS can cause teeth staining. Maintaining good oral hygiene and cleaning the child's teeth after each dose can help minimize this.
Moxclav DS 457 syrup is a combination antibiotic medicine that typically contains amoxicillin and clavulanic acid. In children, it is commonly prescribed for bacterial infections such as middle ear infections (otitis media), sinus infections, some throat and tonsil infections, certain lower respiratory tract infections like bronchitis or pneumonia, and some skin, soft tissue, and urinary tract infections. It should only be used when a doctor has confirmed or strongly suspects a bacterial infection and has specifically prescribed this product.
The correct dose for a child cannot be given in general terms because it depends on the child’s body weight, age, the type and severity of infection, kidney and liver function, and the exact strength of the specific Moxclav DS 457 formulation. Dosing is usually calculated in milligrams per kilogram per day of the amoxicillin component, divided into multiple doses. Only a qualified healthcare professional who knows the child’s clinical details and has the exact product information can determine the appropriate dose and dosing schedule. You should never guess the dose or use another child’s prescription.
The dosing frequency (for example, two or three times a day) is determined by the prescribing doctor based on the infection being treated, the child’s weight and clinical condition, and the specific formulation. Some high‑strength paediatric formulations are given twice daily, while others may be given three times daily. Because the exact product strength and local guidelines vary, you must follow the schedule written on the prescription label and confirmed by your doctor or pharmacist, rather than any generic schedule found online.
You should not rely on online dose calculators or general charts to determine the dose of Moxclav DS 457 syrup for your child. These tools may not account for the exact strength of your specific product, local dosing recommendations, or your child’s kidney and liver function, allergies, or other medical conditions. Miscalculating the dose can lead to under‑treatment or side effects. Always obtain the dose directly from a doctor and have it checked by a pharmacist using the exact product you have.
If you miss a dose, give it as soon as you remember, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and continue with the regular dosing schedule. Do not give a double dose to make up for the missed one, as this may increase the risk of side effects such as stomach upset or diarrhoea. If multiple doses are missed or you are unsure what to do, contact your child’s doctor or pharmacist for advice.
Common side effects in children may include nausea, vomiting, diarrhoea, abdominal discomfort, and mild skin rash. Some children may also develop oral or diaper area thrush due to changes in normal bacterial and fungal balance. These effects are often mild and temporary, but persistent diarrhoea, severe abdominal pain, extensive rash, itching, breathing difficulty, or swelling of the face, lips, or tongue require urgent medical attention, as they may indicate a more serious reaction. Always inform your child’s doctor about any side effects you notice.
Use in children with existing liver disease requires special caution. Amoxicillin–clavulanate has been associated with liver‑related side effects in some patients, especially with prolonged use or repeated courses. If your child has a history of liver problems, jaundice, or abnormal liver tests, the doctor will carefully weigh the benefits and risks, may choose an alternative antibiotic, or may adjust the treatment duration and monitor liver function. Never start or continue this medicine in a child with known liver disease without explicit medical guidance.
In children with reduced kidney function, the dose and dosing interval of amoxicillin–clavulanate often need adjustment to prevent accumulation of the drug and reduce the risk of side effects. The prescribing doctor will usually review kidney function tests and the child’s clinical status before deciding on the dose. Parents should not attempt to adjust the dose themselves. If your child has any kidney condition, inform the doctor and pharmacist before the medicine is dispensed or given.
Moxclav DS 457 syrup should not be given to a child who is known to be allergic to amoxicillin, other penicillins, or any component of the formulation. Caution is also needed in children with a history of severe reactions to cephalosporin antibiotics. Signs of an allergic reaction can include rash, itching, hives, wheezing, difficulty breathing, or swelling of the face, lips, tongue, or throat. If any of these occur, stop the medicine immediately and seek emergency medical care. Always inform the doctor about any previous drug allergies before starting this medicine.
Moxclav DS 457 syrup is formulated for paediatric use, but the active ingredients amoxicillin and clavulanic acid are also used in adults. In pregnancy, these antibiotics are generally considered when clearly needed, but the decision must be made by a doctor after assessing the benefits and potential risks. During breastfeeding, small amounts of the drug can pass into breast milk and may cause loose stools or thrush in the infant. A breastfeeding mother should not take any form of amoxicillin–clavulanate without medical advice. For a child patient, the pregnancy and breastfeeding considerations apply to the mother or caregiver, not to the child.
Moxclav DS 457 syrup is not known to have long‑term effects on a child’s ability to learn, play, or perform tasks such as driving when they are older. In the short term, some children may feel unwell due to the infection itself or may experience side effects like stomach upset, mild dizziness, or tiredness, which can temporarily affect their activity level. Older adolescents who are legally allowed to drive should avoid driving or operating machinery if they feel dizzy or unwell while taking this medicine and should discuss any such symptoms with their doctor.
Moxclav DS 457 syrup is intended for children, and alcohol consumption is not appropriate for paediatric patients. In general, there is no specific direct interaction between amoxicillin–clavulanate and alcohol, but alcohol can worsen side effects such as stomach upset, dizziness, or drowsiness in adults. For caregivers or breastfeeding mothers who are taking an amoxicillin–clavulanate product themselves, it is advisable to limit or avoid alcohol and to follow their doctor’s advice.
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India

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