NAILROX NAIL LACQUER SOLUTION 5ML

How NAILROX NAIL LACQUER SOLUTION 5ML Works

• NAILROX NAIL LACQUER SOLUTION 5ML is an antifungal medication specifically formulated for the treatment of onychomycosis, commonly known as nail fungus. Its effectiveness stems from its active ingredient, amorolfine, which belongs to the morpholine class of antifungals. Amorolfine works by disrupting the synthesis of ergosterol, an essential component of the fungal cell membrane. This disruption compromises the integrity and function of the fungal cell membrane, ultimately leading to fungal cell death.
• Here's a breakdown of how NAILROX works:
• 1. **Penetration:** The lacquer solution is designed to penetrate the nail plate, allowing the amorolfine to reach the site of the infection beneath the nail. The special vehicle in the lacquer helps to facilitate this penetration, ensuring that the antifungal agent comes into direct contact with the fungal pathogens.
• 2. **Inhibition of Ergosterol Synthesis:** Once it reaches the fungus, amorolfine inhibits two key enzymes involved in ergosterol synthesis: Delta-14 reductase and Delta-7/Delta-8 isomerase. Ergosterol is crucial for maintaining the structure and function of the fungal cell membrane. Without sufficient ergosterol, the cell membrane becomes leaky and unstable.
• 3. **Disruption of Fungal Cell Membrane:** The compromised cell membrane leads to a variety of cellular dysfunctions. The fungus is unable to maintain its internal environment, and essential nutrients and ions leak out. This disruption ultimately impairs fungal growth and replication.
• 4. **Fungicidal Action:** Unlike some antifungals that only inhibit fungal growth (fungistatic), amorolfine is fungicidal, meaning it directly kills the fungal cells. This is particularly important in treating nail infections, where complete eradication of the fungus is necessary to prevent recurrence.
• 5. **Broad Spectrum Activity:** Amorolfine exhibits broad-spectrum activity, meaning it is effective against a wide range of fungi that can cause onychomycosis. This includes dermatophytes (such as *Trichophyton*, *Microsporum*, and *Epidermophyton* species), yeasts (such as *Candida* species), and molds. This broad activity ensures that NAILROX can effectively treat infections caused by various fungal pathogens.
• 6. **Long-Lasting Effect:** After application, amorolfine persists in the nail plate for an extended period, providing continued antifungal activity. This allows for less frequent application compared to some other topical antifungal treatments.
• By disrupting ergosterol synthesis and compromising the fungal cell membrane, NAILROX effectively eradicates the fungal infection, allowing for healthy nail regrowth. Consistent and proper application, as directed by a healthcare professional, is crucial for achieving optimal results.

Like all medicines, NAILROX NAIL LACQUER SOLUTION 5ML can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Application site reactions (e.g., burning sensation, itching, redness, swelling, blistering). * Nail disorders (e.g., nail discoloration, nail fragility, changes in nail shape). **Uncommon side effects (may affect up to 1 in 100 people):** * Allergic contact dermatitis. **Rare side effects (may affect up to 1 in 1,000 people):** * Urticaria (hives). **Very rare side effects (may affect up to 1 in 10,000 people):** * Erythema. If any of these side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. This includes possible side effects such as: * Ingrown toenail * Skin peeling around the nail * Headache * Nausea

• If you forget to apply NAILROX NAIL LACQUER SOLUTION 5ML at the regular time, apply it as soon as you remember. However, if it is almost time for your next application, skip the missed one and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

• Keep NAILROX NAIL LACQUER SOLUTION 5ML away from the reach of children and pets.
• Store NAILROX NAIL LACQUER SOLUTION 5ML at room temperature.

• **Nail Preparation is Key:** Before applying NAILROX, ensure your nails are clean, dry, and free of any previous nail polish or oily residue. Use a nail polish remover to thoroughly cleanse the nail surface. Gently file down any uneven edges or rough spots on the nail for a smooth application. Proper nail preparation significantly enhances the adhesion and effectiveness of NAILROX.
• **Apply a Thin, Even Layer:** When applying NAILROX, use the applicator brush to spread a thin, even layer of the solution over the entire affected nail surface. Avoid applying too much solution, as this can lead to a thick, uneven coating that may take longer to dry and could potentially peel off prematurely. One thin coat is typically sufficient for each application.
• **Consistency is Crucial:** For optimal results, apply NAILROX consistently as directed by your healthcare professional. Typically, this involves applying the solution once daily, preferably at bedtime. Adhering to a regular application schedule ensures continuous exposure of the affected nail to the antifungal medication, maximizing its effectiveness in eradicating the infection. Missing applications can prolong the treatment duration.
• **Allow Sufficient Drying Time:** After applying NAILROX, allow the solution to dry completely before exposing your nails to water or other substances. This typically takes a few minutes. Avoid wearing socks or gloves immediately after application, as this can prevent the solution from drying properly. Once dry, NAILROX forms a water-resistant film that protects the nail and delivers the antifungal medication.
• **Trim Infected Nails Regularly:** Regularly trim your infected nails with clean nail clippers to remove any loose or detached portions of the nail. This helps to reduce the reservoir of infection and allows NAILROX to penetrate more effectively to the affected areas. Disinfect the nail clippers after each use to prevent the spread of infection to other nails or individuals. Be careful not to cut the skin around the nails, as this can increase the risk of secondary infections.
• **Avoid Nail Polish and Artificial Nails:** While using NAILROX, avoid applying nail polish or artificial nails on the treated nails. These products can prevent the antifungal medication from reaching the nail bed and can create a moist environment that promotes fungal growth. If you must use nail polish, apply it only after NAILROX has completely dried and remove it promptly. It's best to avoid them altogether during the treatment period.
• **Be Patient and Persistent:** Nail infections can take several months to resolve completely. It is important to be patient and persistent with your NAILROX treatment, even if you do not see immediate results. Continue applying the solution as directed, even after the symptoms begin to improve. Premature discontinuation of treatment can lead to recurrence of the infection. Consult with your healthcare provider if you have any concerns or if your symptoms do not improve after several months of treatment.

• NAILROX NAIL LACQUER SOLUTION 5ML is for external use only and is unlikely to interact with food. However, to avoid any potential contamination, it is advisable to apply the medication after meals or snacks.