NEBICARD V TABLET 10'S

How NEBICARD V TABLET 10'S Works

• NEBICARD V TABLET 10'S is a combination medication primarily used to treat hypertension (high blood pressure). It combines two active ingredients, Nebivolol and Valsartan, each working through different mechanisms to lower blood pressure and improve cardiovascular health.
• **Nebivolol:** Nebivolol is a beta-adrenergic receptor blocker, often referred to as a beta-blocker. However, Nebivolol is unique among beta-blockers due to its additional property of stimulating the production of nitric oxide (NO). Beta-blockers work by blocking the effects of epinephrine (adrenaline) on the heart and blood vessels. This results in several beneficial effects:
• 1. **Decreased Heart Rate:** By blocking beta-adrenergic receptors in the heart, Nebivolol slows down the heart rate. This reduces the heart's workload and oxygen demand.
• 2. **Reduced Contraction Force:** Nebivolol decreases the force with which the heart muscle contracts, further reducing the heart's workload.
• 3. **Vasodilation:** Nebivolol promotes the production of nitric oxide (NO) in the blood vessel walls. NO is a potent vasodilator, meaning it widens blood vessels. This vasodilation reduces peripheral resistance, allowing blood to flow more easily and reducing blood pressure.
• **Valsartan:** Valsartan is an angiotensin II receptor blocker (ARB). Angiotensin II is a hormone that causes blood vessels to constrict, leading to increased blood pressure. Valsartan works by:
• 1. **Blocking Angiotensin II Receptors:** Valsartan selectively blocks angiotensin II receptors, particularly AT1 receptors, in blood vessels and other tissues. This prevents angiotensin II from binding to these receptors.
• 2. **Vasodilation:** By blocking the effects of angiotensin II, Valsartan promotes vasodilation, widening blood vessels and reducing blood pressure.
• 3. **Reduced Aldosterone Release:** Angiotensin II also stimulates the release of aldosterone, a hormone that causes the kidneys to retain sodium and water, increasing blood volume and blood pressure. Valsartan reduces aldosterone release, further helping to lower blood pressure.
• **Synergistic Effect:** The combination of Nebivolol and Valsartan in NEBICARD V TABLET 10'S provides a synergistic effect. Nebivolol reduces heart rate and promotes vasodilation through nitric oxide, while Valsartan blocks the vasoconstricting effects of angiotensin II and reduces aldosterone release. Together, they provide a more comprehensive approach to lowering blood pressure than either medication alone.
• In summary, NEBICARD V TABLET 10'S works by combining a beta-blocker that also stimulates nitric oxide production with an angiotensin II receptor blocker. This dual mechanism effectively lowers blood pressure by reducing heart rate, promoting vasodilation, and reducing sodium and water retention, ultimately improving cardiovascular health.

Common side effects of Nebicard V Tablet may include headache, dizziness, fatigue, slow heartbeat, nausea, diarrhea, constipation, and swelling in the ankles or feet. Less common side effects can include shortness of breath, difficulty breathing, chest pain, irregular heartbeat, low blood pressure, cold or numb extremities, muscle cramps, visual disturbances, dry eyes, impotence, allergic reactions (rash, itching, swelling), sleep disturbances, depression, and confusion. In rare cases, it may exacerbate existing heart conditions. Consult your doctor if you experience any persistent or severe side effects.

• If you miss a dose of NEBICARD V TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep NEBICARD V TAB 1X10 away from the reach of children and pets.
• Store NEBICARD V TAB 1X10 at room temperature.

• Take NEBICARD V TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider. Sudden discontinuation can lead to serious heart problems.
• NEBICARD V TABLET 10'S is typically taken once daily, with or without food. Try to take it at the same time each day to help you remember and maintain a consistent level of medication in your body. Consistency is key for optimal results.
• Before starting NEBICARD V TABLET 10'S, inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins. Certain medications can interact with NEBICARD V TABLET 10'S, affecting its efficacy or increasing the risk of side effects. Pay special attention to cold remedies, decongestants, and other heart medications.
• Monitor your blood pressure and heart rate regularly while taking NEBICARD V TABLET 10'S. Keep a record of these measurements and share them with your doctor during your check-ups. This helps your doctor assess how well the medication is working and make any necessary adjustments to your treatment plan. If you notice any significant changes or irregularities, contact your doctor immediately.
• NEBICARD V TABLET 10'S can sometimes cause dizziness or lightheadedness, especially when you first start taking it or when the dosage is increased. To minimize these effects, rise slowly when getting up from a sitting or lying position. Avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you. If dizziness persists or worsens, consult your doctor.
• Lifestyle modifications such as maintaining a healthy diet, exercising regularly, and managing stress can complement the effects of NEBICARD V TABLET 10'S. These changes can help improve your overall cardiovascular health and reduce your risk of heart-related complications. Consult your doctor for personalized advice on lifestyle changes that are right for you.
• Be aware of potential side effects of NEBICARD V TABLET 10'S, such as fatigue, headache, slow heart rate, and swelling in the ankles or feet. While not everyone experiences these side effects, it's important to be informed and know when to seek medical attention. Report any bothersome or persistent side effects to your doctor promptly.
• Store NEBICARD V TABLET 10'S at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or shows signs of damage. Proper storage helps maintain the effectiveness and safety of the medication.

• NEBICARD V TABLET 10'S can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent levels of the medication in your body. Avoid consuming large amounts of grapefruit or grapefruit juice while taking this medicine, as it can increase the levels of nebivolol in your blood, potentially leading to increased side effects. Alcohol consumption should be limited or avoided, as it can enhance the blood-pressure-lowering effects of the medication.