NEBISTAR SA TABLET 15'S
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NEBISTAR SA TABLET 15'S

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NEBISTAR SA TABLET 15'S

By LUPIN LIMITED

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388.92

₹330.58

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Product DetailsArrow

Content Reviewed By:

Dr. Sanjay Mehta

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About NEBISTAR SA TABLET 15'S

  • Nebistar SA is a prescription combination medicine that contains nebivolol and S-amlodipine. It is generally used for the management of high blood pressure (essential hypertension) in adults when treatment with a single medicine is not sufficient to control blood pressure. Nebivolol is a cardioselective beta-1 adrenergic receptor blocker with additional nitric oxide–mediated vasodilatory properties. It reduces heart rate, decreases the force of contraction of the heart, and lowers blood pressure. S-amlodipine is the active (S) enantiomer of amlodipine, a dihydropyridine calcium channel blocker. It relaxes and widens blood vessels by inhibiting calcium entry into vascular smooth muscle cells, which helps reduce peripheral vascular resistance and blood pressure. By combining these two mechanisms, Nebistar SA helps to lower blood pressure more effectively than either component alone in many patients. Adequate control of blood pressure is important to reduce the risk of complications such as stroke, heart attack, heart failure, and kidney damage. The medicine is usually intended for long-term use under medical supervision. It should be taken exactly as prescribed and not started, stopped, or changed without consulting a healthcare professional. Commonly reported side effects may include headache, dizziness, fatigue, slow heart rate, ankle or leg swelling, flushing, palpitations, nausea, abdominal discomfort, and sleep disturbances. Many side effects are mild and transient, but some, such as marked slowing of the heart rate, severe dizziness, shortness of breath, new or worsening chest pain, or significant swelling, require prompt medical attention. Nebistar SA may not be suitable for people with certain heart conditions (such as severe bradycardia, heart block, cardiogenic shock, or decompensated heart failure), severe liver impairment, or very low blood pressure. It should be used cautiously in patients with kidney disease, diabetes, peripheral vascular disease, or a history of asthma or other bronchospastic disorders. Nebistar SA can interact with other medicines, including some antihypertensives, antiarrhythmics, antidepressants, antipsychotics, and drugs that affect heart rate or blood vessel tone. Patients should inform their doctor about all prescription medicines, over-the-counter products, and herbal supplements they are taking. Abrupt discontinuation of beta-blockers like nebivolol may lead to rebound increases in blood pressure or worsening of underlying heart disease; any dose reduction should be gradual and supervised. Lifestyle measures such as dietary modification, regular physical activity as advised, weight management, smoking cessation, and limiting alcohol intake should be followed alongside Nebistar SA to achieve optimal blood pressure control. Nebistar SA is not recommended for use in children unless specifically advised by a specialist. Its use during pregnancy and breastfeeding requires careful risk–benefit assessment by a doctor. Patients should be regularly monitored for blood pressure, heart rate, and, when indicated, kidney and liver function while on this medicine.

Uses of NEBISTAR SA TABLET 15'S

  • Treatment of Hypertension (High Blood Pressure)
  • Treatment of Heart Failure
  • Treatment of Angina (Chest Pain)

How NEBISTAR SA TABLET 15'S Works

  • NEBISTAR SA TABLET 15'S is a combination medication primarily used to manage hypertension (high blood pressure). It combines nebivolol and valsartan, each working through distinct mechanisms to lower blood pressure effectively.
  • Nebivolol is a beta-blocker that selectively blocks beta-1 adrenergic receptors, mainly found in the heart. By blocking these receptors, nebivolol slows down the heart rate and reduces the force of heart muscle contraction. This decreased cardiac output lowers blood pressure. Additionally, nebivolol stimulates the production of nitric oxide (NO) in the blood vessels. Nitric oxide is a vasodilator, meaning it helps relax and widen the blood vessels. This vasodilation further contributes to reduced blood pressure and improved blood flow.
  • Valsartan, on the other hand, is an angiotensin II receptor blocker (ARB). Angiotensin II is a hormone that causes blood vessels to constrict, increasing blood pressure. It also stimulates the release of aldosterone, which leads to sodium and water retention by the kidneys, further elevating blood pressure. Valsartan blocks the action of angiotensin II by binding to the angiotensin II receptors in blood vessels and the adrenal gland. This prevents vasoconstriction and reduces aldosterone secretion. As a result, blood vessels relax, and the kidneys excrete more sodium and water, lowering blood volume and blood pressure.
  • The synergistic action of nebivolol and valsartan provides a comprehensive approach to blood pressure management. Nebivolol reduces cardiac output and increases vasodilation, while valsartan prevents vasoconstriction and reduces fluid retention. This combination effectively lowers blood pressure, reducing the risk of cardiovascular events such as heart attack, stroke, and kidney damage. Regular use of NEBISTAR SA TABLET 15'S, as prescribed by a healthcare professional, helps maintain healthy blood pressure levels and protects overall cardiovascular health. It is important to take the medication consistently and follow any lifestyle recommendations provided by your doctor, such as diet and exercise, to maximize its benefits.
  • This medicine should be taken at the same time each day, preferably with or without food, as directed by your physician. Consistency is key to maintaining optimal blood pressure control.

Side Effects of NEBISTAR SA TABLET 15'SArrow

Common side effects of Nebistar SA Tablet may include headache, dizziness, fatigue, and nausea. Some individuals might experience slow heartbeat, low blood pressure, shortness of breath, and swelling in the ankles or feet. Less common side effects can include diarrhea, constipation, vomiting, skin rash, itching, and visual disturbances. In rare cases, Nebistar SA Tablet can cause Raynaud's phenomenon (numbness and coldness in fingers and toes), worsening of psoriasis, and confusion or hallucinations. If you experience any severe or persistent side effects, it is crucial to consult your doctor.

Safety Advice for NEBISTAR SA TABLET 15'SArrow

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Heart and circulation

Use under specialist supervision

Nebistar SA affects heart rate, cardiac contractility, and vascular tone, and must be used carefully in patients with pre-existing heart disease.

Dosage of NEBISTAR SA TABLET 15'SArrow

  • The recommended dosage of NEBISTAR SA TABLET 15'S varies depending on individual patient needs and the condition being treated. It is crucial to adhere strictly to your physician's instructions regarding dosage and duration of treatment. Typically, the starting dose is one tablet daily, but this may be adjusted by your doctor based on your response and tolerance to the medication. The tablet should be swallowed whole with a glass of water, and it can be taken with or without food, but consistency in timing is advised.
  • For patients with certain pre-existing conditions, such as kidney or liver impairment, or those who are elderly, the dosage may need to be carefully adjusted by your healthcare provider to minimize the risk of side effects. Do not exceed the prescribed dose or discontinue the medication without consulting your doctor, as this could lead to adverse effects or a worsening of your condition. Regular monitoring and follow-up appointments with your doctor are essential to assess your progress and make any necessary adjustments to your treatment plan.
  • The duration of treatment with NEBISTAR SA TABLET 15'S also varies depending on the condition being treated. Some patients may require long-term therapy, while others may only need a short course. Always complete the full course of treatment as prescribed by your doctor, even if you start to feel better. If you have any concerns or questions about your dosage or treatment plan, do not hesitate to ask your doctor or pharmacist for clarification. Take 'NEBISTAR SA TABLET 15'S' only as per the prescription by your physician only.

What if I miss my dose of NEBISTAR SA TABLET 15'S?Arrow

  • If you miss a dose of NEBISTAR SA TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How to store NEBISTAR SA TABLET 15'S?Arrow

  • Keep NEBISTAR SA TAB 1X15 away from the reach of children and pets.
  • Store NEBISTAR SA TAB 1X15 at room temperature.

Benefits of NEBISTAR SA TABLET 15'SArrow

  • NEBISTAR SA TABLET 15'S offers a multifaceted approach to managing hypertension and related cardiovascular conditions, providing a comprehensive set of benefits for improved patient health and well-being. Its primary advantage lies in its ability to effectively lower blood pressure, reducing the strain on the heart and blood vessels. This is achieved through the synergistic action of its components, which work together to promote vasodilation and reduce peripheral resistance.
  • One of the key benefits of NEBISTAR SA TABLET 15'S is its cardioprotective effect. By reducing blood pressure, it helps to prevent damage to the heart muscle and reduces the risk of developing heart failure. Furthermore, it helps improve overall heart function, making the heart more efficient at pumping blood throughout the body.
  • NEBISTAR SA TABLET 15'S also plays a crucial role in preventing stroke. High blood pressure is a major risk factor for stroke, and by effectively controlling blood pressure, this medication significantly lowers the likelihood of this debilitating event. The sustained reduction in blood pressure provided by NEBISTAR SA TABLET 15'S contributes to long-term cerebrovascular health.
  • Beyond its effects on blood pressure and cardiovascular health, NEBISTAR SA TABLET 15'S can improve kidney function. Uncontrolled hypertension can damage the kidneys over time, leading to kidney disease. By maintaining healthy blood pressure levels, this medication helps protect the kidneys and preserve their function. This is particularly beneficial for individuals with existing kidney conditions or those at risk of developing them.
  • NEBISTAR SA TABLET 15'S can also help manage the symptoms associated with hypertension, such as headaches, dizziness, and blurred vision. By lowering blood pressure, it alleviates these symptoms, improving the patient's overall quality of life. This allows individuals to engage in daily activities with greater comfort and ease.
  • This medication promotes better exercise tolerance in individuals with hypertension. By reducing the workload on the heart, it enables patients to engage in physical activity with less fatigue and shortness of breath. This can lead to improved cardiovascular fitness and a greater sense of well-being.
  • NEBISTAR SA TABLET 15'S is often prescribed as part of a comprehensive treatment plan for hypertension. It can be used alone or in combination with other medications to achieve optimal blood pressure control. Its versatility makes it a valuable tool for healthcare professionals in managing hypertension across a wide range of patients.
  • In addition to its direct effects on blood pressure, NEBISTAR SA TABLET 15'S can also have a positive impact on overall metabolic health. Studies have shown that it can improve insulin sensitivity and reduce the risk of developing type 2 diabetes, particularly in individuals with pre-existing insulin resistance.
  • NEBISTAR SA TABLET 15'S is generally well-tolerated, with a low incidence of side effects. This makes it a suitable option for long-term management of hypertension, allowing patients to adhere to their treatment regimen without experiencing significant adverse effects. However, as with any medication, it is important to follow the doctor's instructions and report any unusual symptoms.
  • Finally, NEBISTAR SA TABLET 15'S contributes to improved long-term cardiovascular outcomes. By effectively managing hypertension and its associated risk factors, it helps to reduce the risk of heart attack, stroke, kidney disease, and other serious cardiovascular events. This translates to a longer and healthier life for individuals with hypertension.

How to use NEBISTAR SA TABLET 15'SArrow

  • NEBISTAR SA TABLET 15'S should be taken orally, preferably at the same time each day to maintain consistent blood levels and maximize its effectiveness. It can be taken with or without food, but consistency in how you take it (always with food or always without) is advisable for predictable absorption.
  • The usual starting dose will be determined by your doctor based on your specific condition and other medications you may be taking. It's crucial to adhere to the prescribed dosage. Do not increase or decrease the dose without consulting your healthcare provider, as this could lead to unwanted side effects or reduced effectiveness.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet unless specifically instructed by your doctor, as this could affect how the medication is released into your system.
  • If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
  • NEBISTAR SA TABLET 15'S is often prescribed as part of a comprehensive treatment plan that includes lifestyle modifications such as diet, exercise, and stress management. Follow your doctor's recommendations for these lifestyle changes to optimize the benefits of the medication.
  • Continue taking NEBISTAR SA TABLET 15'S even if you feel well. Many people with high blood pressure or heart conditions do not experience noticeable symptoms, and it's essential to manage these conditions consistently to prevent long-term complications. Do not stop taking the medication abruptly without consulting your doctor, as this could lead to a sudden increase in blood pressure or other adverse effects.
  • Regular monitoring by your doctor is necessary while taking NEBISTAR SA TABLET 15'S. This may involve checking your blood pressure, heart rate, and other relevant parameters to ensure the medication is working effectively and to monitor for any potential side effects. Keep all your scheduled appointments with your doctor.
  • Inform your doctor about all other medications, supplements, and herbal products you are taking, as they may interact with NEBISTAR SA TABLET 15'S. Certain medications can affect the way NEBISTAR SA TABLET 15'S works, and your doctor may need to adjust your dosage accordingly.
  • If you experience any unusual or bothersome side effects, such as dizziness, fatigue, slow heartbeat, or swelling in your ankles or feet, contact your doctor immediately. Do not attempt to self-treat side effects, as this could be harmful.
  • Store NEBISTAR SA TABLET 15'S at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets.

Quick Tips for NEBISTAR SA TABLET 15'SArrow

  • **Take NEBISTAR SA TABLET 15'S exactly as prescribed by your doctor.** Do not change the dose or stop taking the medication without consulting them, as this could lead to serious heart problems. Usually it is recommended to take at same time each day to maintain consisten level of medicine in the body.
  • **Monitor your blood pressure and heart rate regularly while taking NEBISTAR SA TABLET 15'S.** Keep a record of these measurements and share them with your doctor during follow-up appointments. This helps in dose adjustments and monitoring the effectiveness of the medication.
  • **Inform your doctor about all other medications, supplements, or herbal products you are taking.** NEBISTAR SA TABLET 15'S can interact with other drugs, potentially affecting how they work or increasing the risk of side effects. Be especially cautious with cold remedies, NSAIDs (like ibuprofen), and certain antidepressants.
  • **Be aware of potential side effects and what to do.** Common side effects include dizziness, fatigue, headache, and slow heart rate. If you experience any severe or persistent side effects, such as shortness of breath, chest pain, or swelling in your ankles/feet, seek immediate medical attention. Also, rise slowly from sitting or lying down to minimize dizziness.
  • **Maintain a healthy lifestyle to support the effectiveness of NEBISTAR SA TABLET 15'S.** This includes following a balanced diet low in sodium and saturated fats, engaging in regular physical activity (as advised by your doctor), managing stress, and avoiding excessive alcohol consumption. Quitting smoking is also highly recommended for overall cardiovascular health.
  • **If you have diabetes, monitor your blood sugar levels closely.** NEBISTAR SA TABLET 15'S may mask some of the symptoms of low blood sugar, making it harder to recognize. Consult your doctor for advice on managing your diabetes effectively while taking this medication.

Food Interactions with NEBISTAR SA TABLET 15'SArrow

  • NEBISTAR SA TABLET 15'S may be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent blood levels. Avoid consuming large amounts of grapefruit juice while taking this medicine, as it may increase the blood levels of nebivolol.

FAQs

What is Nebistar SA Tablet 15's and what is it used for?Arrow

Nebistar SA Tablet 15's contains nebivolol as an active ingredient. It is primarily used to treat hypertension (high blood pressure).

How does Nebistar SA Tablet 15's work?Arrow

Nebistar SA Tablet 15's works by relaxing blood vessels and slowing down the heart rate, which lowers blood pressure.

What are the common side effects of Nebistar SA Tablet 15's?Arrow

Common side effects of Nebistar SA Tablet 15's include dizziness, fatigue, headache, and slow heart rate.

Can I take Nebistar SA Tablet 15's with or without food?Arrow

Nebistar SA Tablet 15's can be taken with or without food, but it's best to take it at the same time each day.

What happens if I miss a dose of Nebistar SA Tablet 15's?Arrow

If you miss a dose of Nebistar SA Tablet 15's, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Is it safe to stop taking Nebistar SA Tablet 15's abruptly?Arrow

Stopping Nebistar SA Tablet 15's abruptly can cause a sudden increase in blood pressure, so it is advisable to gradually reduce the dose.

What medications should not be taken with Nebistar SA Tablet 15's?Arrow

Nebistar SA Tablet 15's can interact with certain other medications, such as some heart medications, antidepressants, and antifungals. Consult your doctor before starting any new medication.

Is it safe to take Nebistar SA Tablet 15's during pregnancy?Arrow

The safety of taking Nebistar SA Tablet 15's during pregnancy has not been established. Consult your doctor if you are pregnant or planning to become pregnant.

Is it safe to take Nebistar SA Tablet 15's during breastfeeding?Arrow

It is not known whether Nebistar SA Tablet 15's passes into breast milk. Consult your doctor before breastfeeding.

How should Nebistar SA Tablet 15's be stored?Arrow

Nebistar SA Tablet 15's should be stored at room temperature, away from heat and moisture. Keep it out of the reach of children.

Is Nebistar SA Tablet 15's used for heart failure?Arrow

Yes, Nebistar SA Tablet 15's can be used to treat heart failure, but only under the supervision of a doctor.

Can Nebistar SA Tablet 15's affect my sexual ability?Arrow

In some cases, Nebistar SA Tablet 15's can affect sexual ability. Talk to your doctor if you are concerned about this.

What are the symptoms of an overdose of Nebistar SA Tablet 15's?Arrow

Symptoms of an overdose of Nebistar SA Tablet 15's may include slow heart rate, low blood pressure, difficulty breathing, and fainting.

Is it safe to drink alcohol while taking Nebistar SA Tablet 15's?Arrow

Drinking alcohol while taking Nebistar SA Tablet 15's can increase its blood pressure-lowering effect and increase the risk of side effects such as dizziness. It is advisable to avoid alcohol.

How long does it take to see results from Nebistar SA Tablet 15's?Arrow

It may take a few weeks to see the full effects of Nebistar SA Tablet 15's. It is important to monitor your blood pressure regularly and follow your doctor's instructions.

What is Nebistar SA used for?Arrow

Nebistar SA is primarily used to treat high blood pressure (essential hypertension) in adults. It combines nebivolol, a beta-blocker, and S-amlodipine, a calcium channel blocker, to lower blood pressure by slowing the heart rate, reducing the force of heart contractions, and relaxing blood vessels. Adequate blood pressure control helps reduce the risk of stroke, heart attack, and other cardiovascular complications.

How does Nebistar SA work in the body?Arrow

Nebistar SA contains two active components. Nebivolol selectively blocks beta-1 receptors in the heart, which slows the heart rate and decreases the heart’s workload. It also promotes nitric oxide–mediated vasodilation, helping blood vessels relax. S-amlodipine blocks L-type calcium channels in vascular smooth muscle, leading to dilation of peripheral arteries and reduced vascular resistance. The combined effect is a sustained reduction in blood pressure.

Can Nebistar SA be taken on an empty stomach?Arrow

Nebistar SA can generally be taken with or without food. However, it is advisable to take it at the same time each day in a consistent manner, either always with food or always without, to maintain stable absorption. Patients should follow the specific instructions provided by their doctor or on the dispensing label and should not alter the timing or conditions of intake without medical advice.

What should I do if I miss a dose of Nebistar SA?Arrow

If you miss a dose of Nebistar SA, take it as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may cause excessive lowering of blood pressure or heart rate. If you frequently forget doses, discuss strategies with your healthcare provider.

What are the common side effects of Nebistar SA?Arrow

Common side effects of Nebistar SA may include headache, dizziness, fatigue, drowsiness, slow heart rate, flushing, ankle or leg swelling, palpitations, nausea, abdominal discomfort, and sleep disturbances. Mild side effects often improve as the body adjusts to treatment. However, if side effects are persistent, troublesome, or severe, such as marked slowing of the heart rate, severe dizziness, breathing difficulty, or significant swelling, medical attention is required.

Is Nebistar SA safe for patients with diabetes?Arrow

Nebistar SA can be used in some patients with diabetes, but it requires careful monitoring. Beta-blockers like nebivolol may mask certain symptoms of low blood sugar, such as palpitations and tremors, making hypoglycaemia harder to recognize. Blood glucose levels should be monitored regularly, and antidiabetic therapy may need adjustment. Patients with diabetes should inform their doctor before starting Nebistar SA and report any unusual symptoms promptly.

Can I stop taking Nebistar SA once my blood pressure is controlled?Arrow

Nebistar SA should not be stopped abruptly, even if blood pressure becomes well controlled. Sudden discontinuation of beta-blockers can lead to rebound increases in blood pressure, rapid heart rate, or worsening of underlying heart disease. Any change in therapy, including dose reduction or discontinuation, must be done gradually and only under medical supervision. Your doctor will decide if and when it is appropriate to adjust or stop the medicine.

Does Nebistar SA cause ankle or leg swelling?Arrow

Yes, ankle or leg swelling (peripheral oedema) can occur with S-amlodipine, one of the components of Nebistar SA, due to dilation of peripheral blood vessels. Mild swelling is relatively common and may be dose-related. If swelling is significant, painful, associated with shortness of breath, or rapidly worsening, you should contact your doctor, as dose adjustment, evaluation for heart or kidney issues, or a change in therapy may be necessary.

Can Nebistar SA be used during pregnancy?Arrow

Use of Nebistar SA during pregnancy is generally not recommended unless the potential benefit clearly outweighs the potential risk to the fetus. Both nebivolol and S-amlodipine may affect fetal circulation and growth. Pregnant women or those planning to become pregnant should inform their doctor before starting this medicine. The doctor may consider alternative antihypertensive agents with a better-established safety profile in pregnancy.

Is Nebistar SA habit-forming or addictive?Arrow

Nebistar SA is not known to be habit-forming or addictive. It does not produce euphoria or craving. However, it is a long-term cardiovascular medication that should be taken regularly as prescribed. Stopping or altering the dose without medical guidance can be harmful, even though the medicine itself does not cause dependence in the conventional sense.

Can I drink alcohol while taking Nebistar SA?Arrow

Alcohol can enhance the blood pressure–lowering effect of Nebistar SA and may increase the risk of dizziness, light-headedness, or fainting, especially when standing up quickly. It is advisable to limit or avoid alcohol consumption while on this medicine. Patients who choose to drink should do so cautiously and be alert to symptoms of low blood pressure. Discuss alcohol use with your doctor for individualized advice.

Is Nebistar SA suitable for elderly patients?Arrow

Nebistar SA can be used in elderly patients, but they may be more sensitive to its blood pressure–lowering and heart rate–reducing effects. Treatment is usually started cautiously, with close monitoring of blood pressure, heart rate, kidney function, and any symptoms such as dizziness, falls, or worsening shortness of breath. Dose adjustments may be required based on tolerance and clinical response.

References

Book Icon

Nebistar SmPC - electronic Medicines Compendium. Provides detailed pharmaceutical information, including composition, pharmacological properties, therapeutic indications, contraindications, special warnings and precautions for use, interaction with other medicinal products and other forms of interaction, fertility, pregnancy and lactation, effects on ability to drive and use machines, undesirable effects, overdose, and pharmaceutical particulars.

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Nebivolol DrugBank entry. A comprehensive resource on Nebivolol, including its mechanism of action, pharmacokinetics, indications, contraindications, and interactions.

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Nebivolol PubChem entry. Provides chemical and physical properties, safety and hazard information, and links to related literature and resources.

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Book Icon

PubMed Central. A free archive of biomedical and life sciences literature. Search for articles related to Nebivolol and its clinical applications.

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Book Icon

European Medicines Agency (EMA). Search for scientific information and regulatory guidelines related to Nebivolol.

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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