NEBISTAR T TABLET 10'S

How NEBISTAR T TABLET 10'S Works

• NEBISTAR T Tablet 10's is a combination medication designed to manage hypertension, commonly known as high blood pressure. It combines two active ingredients: nebivolol and telmisartan. Each component works through different mechanisms to lower blood pressure effectively.
• **Nebivolol's Mechanism of Action:** Nebivolol is a beta-blocker, but unlike traditional beta-blockers, it is highly selective for beta-1 adrenergic receptors. These receptors are primarily located in the heart. By selectively blocking these receptors, nebivolol reduces the heart rate and the force of heart contractions. This leads to a decrease in cardiac output, which is the amount of blood the heart pumps per minute. Lowering cardiac output helps to reduce blood pressure.
• Moreover, nebivolol possesses a unique property of stimulating the release of nitric oxide (NO) from the endothelial cells lining the blood vessels. Nitric oxide is a potent vasodilator, meaning it causes blood vessels to relax and widen. This vasodilation further contributes to lowering blood pressure by reducing peripheral resistance, the resistance to blood flow in the arteries.
• **Telmisartan's Mechanism of Action:** Telmisartan belongs to a class of drugs called angiotensin II receptor blockers (ARBs). Angiotensin II is a hormone in the body that causes blood vessels to constrict, leading to increased blood pressure. It also triggers the release of aldosterone, a hormone that promotes sodium and water retention by the kidneys, further increasing blood volume and pressure.
• Telmisartan works by selectively blocking the angiotensin II receptors, specifically the AT1 receptors, found in various tissues such as blood vessels and the adrenal glands. By blocking these receptors, telmisartan prevents angiotensin II from exerting its vasoconstricting effects. This allows blood vessels to relax and widen, reducing blood pressure. Additionally, by blocking the action of angiotensin II on the adrenal glands, telmisartan reduces aldosterone release, promoting the excretion of sodium and water, which further helps to lower blood pressure.
• **Synergistic Effect:** The combination of nebivolol and telmisartan in NEBISTAR T Tablet 10's provides a synergistic effect in managing hypertension. Nebivolol lowers blood pressure by reducing cardiac output and promoting vasodilation through nitric oxide release, while telmisartan lowers blood pressure by blocking the vasoconstricting effects of angiotensin II and promoting sodium and water excretion. Together, they offer a comprehensive approach to blood pressure control.
• The combined action helps to achieve better blood pressure control than either drug could achieve alone, thereby reducing the risk of cardiovascular events such as heart attack, stroke, and kidney problems associated with uncontrolled hypertension. It is crucial to take NEBISTAR T Tablet 10's as prescribed by your doctor to achieve optimal blood pressure control and minimize the risk of adverse effects.

Common side effects of Nebistar T Tablet may include headache, dizziness, fatigue, slow heart rate, nausea, diarrhea, constipation, and cold extremities. Less common but potentially serious side effects include: allergic reactions (rash, itching, swelling), shortness of breath, chest pain, worsening of heart failure, low blood pressure, muscle cramps, changes in blood sugar levels (especially in diabetics), and mood changes. Other reported side effects are: visual disturbances, dry eyes, impotence, and Raynaud's phenomenon (numbness and paleness in fingers and toes). This is not an exhaustive list, and it's important to consult with your doctor if you experience any unusual or bothersome symptoms while taking Nebistar T Tablet.

• If you miss a dose of NEBISTAR T TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep NEBISTAR T TAB 1X10 away from the reach of children and pets.
• Store NEBISTAR T TAB 1X10 at room temperature.

• Take NEBISTAR T TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medicine without consulting your doctor, as this could worsen your condition. It's typically taken once daily, with or without food, but try to take it at the same time each day to maintain a consistent level in your body and help you remember.
• NEBISTAR T TABLET 10'S is a combination medicine containing telmisartan and nebivolol which are used to treat high blood pressure. Telmisartan is an angiotensin receptor blocker (ARB) and Nebivolol is beta blocker. Lifestyle modifications such as a low-sodium diet, regular exercise, and stress management can significantly enhance the effectiveness of NEBISTAR T TABLET 10'S in controlling blood pressure. Discuss these strategies with your doctor.
• Monitor your blood pressure regularly while taking NEBISTAR T TABLET 10'S. Keep a log of your readings and share it with your doctor during check-ups. This helps your doctor assess how well the medication is working and make any necessary adjustments to your treatment plan. Regular monitoring is crucial for managing hypertension effectively.
• Be aware of potential side effects. Common side effects of NEBISTAR T TABLET 10'S may include dizziness, fatigue, slow heart rate, or swelling in the ankles or feet. If you experience any severe or persistent side effects, such as difficulty breathing, chest pain, or an irregular heartbeat, seek immediate medical attention. Do not ignore persistent symptoms.
• Inform your doctor about all other medications, supplements, and herbal remedies you are taking before starting NEBISTAR T TABLET 10'S. Certain medications can interact with NEBISTAR T TABLET 10'S, affecting its effectiveness or increasing the risk of side effects. This includes other blood pressure medications, heart medications, and certain pain relievers. Always keep your doctor informed about your complete medication list.

• NEBISTAR T TABLET 10'S can be taken with or without food, but it is important to take it at the same time each day to maintain consistent blood levels. Avoid consuming large amounts of grapefruit or grapefruit juice while taking this medication, as it can increase the levels of nebivolol in your blood, potentially leading to increased side effects. Alcohol consumption should be limited, as it may enhance the blood-pressure-lowering effects of the medication.