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NICARDIA 20MG RETARD TABLET 15'S

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NICARDIA 20MG RETARD TABLET 15'S

By J B CHEMICALS AND PHARMACEUTICALS LTD

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Product DetailsArrow

Content Reviewed By:

Dr. Sanjay Mehta

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About NICARDIA 20MG RETARD TABLET 15'S

  • Nicardia Retard 20 is a branded modified-release formulation of nifedipine, a calcium channel blocker belonging to the dihydropyridine class. It is primarily used for the management of high blood pressure (hypertension) and certain types of chronic stable angina (chest pain due to reduced blood flow to the heart). By relaxing and widening blood vessels, nifedipine lowers peripheral vascular resistance, which helps reduce blood pressure and improve blood flow to the heart muscle. The “retard” or sustained-release form is designed to release the medicine slowly over time, providing more stable blood levels and a longer duration of action compared with immediate-release formulations. In hypertension, Nicardia Retard 20 is used as part of long-term blood pressure control to reduce the risk of complications such as stroke, heart attack, heart failure, and kidney damage. It may be prescribed alone or in combination with other antihypertensive agents such as ACE inhibitors, angiotensin receptor blockers, diuretics, or beta-blockers, depending on individual patient needs and comorbidities. In chronic stable angina, it helps prevent episodes of chest pain by decreasing the workload on the heart and improving coronary blood flow. It is used for prophylaxis and not for rapid relief of acute angina attacks. Nifedipine may also be used off-label in certain settings, such as some forms of Raynaud’s phenomenon, where it can help reduce frequency and severity of vasospastic attacks in the fingers and toes. However, such uses should be guided strictly by a specialist. The exact indication for Nicardia Retard 20 in any individual patient depends on the clinical assessment, cardiovascular risk profile, and response to other therapies. Nicardia Retard 20 should always be taken under medical supervision. The tablet must be swallowed whole with water and should not be crushed, chewed, or split, as this can interfere with the modified-release mechanism and may increase the risk of adverse effects. Patients should not adjust the dose or stop the medicine abruptly without consulting their prescriber, as sudden withdrawal may worsen angina or destabilize blood pressure control. Regular monitoring of blood pressure, heart rate, and clinical symptoms is important to ensure safe and effective use. Patients should inform their healthcare provider about all other medicines, supplements, and herbal products they are taking, as nifedipine has clinically relevant drug–drug interactions, including with certain antibiotics, antifungals, and other cardiovascular agents. Any new or worsening chest pain, marked dizziness, fainting, or swelling of the ankles or feet should be reported promptly.

Uses of NICARDIA 20MG RETARD TABLET 15'S

  • Manages High Blood Pressure (Hypertension).
  • Treats Angina Pectoris (Chest Pain).

How NICARDIA 20MG RETARD TABLET 15'S Works

  • NICARDIA 20MG RETARD TABLET 15'S works by blocking calcium channels in blood vessels, which relaxes and widens them, resulting in improved blood flow and reduced blood pressure.
  • NICARDIA 20MG RETARD TABLET 15'S exerts its effects by blocking the influx of calcium ions through specific channels in the smooth muscle cells of blood vessels. By doing so, it reduces the contractility of the arterial walls, leading to relaxation and dilation of the blood vessels. This action helps to lower blood pressure and improve blood flow to the heart, reducing the workload on the organ. Additionally, the relaxation of smooth muscle in the coronary arteries enhances blood supply to the heart muscle, alleviating chest pain (angina). Furthermore, NICARDIA 20MG RETARD TABLET 15'S inhibits calcium ion influx in the myometrium (muscle layer of the uterus), which helps prevent preterm contractions. Overall, these mechanisms contribute to the therapeutic benefits of NICARDIA 20MG RETARD TABLET 15'S in hypertension, angina, and preterm labor prevention.

Side Effects of NICARDIA 20MG RETARD TABLET 15'SArrow

Side effects are unwanted symptoms caused by NICARDIA 20MG RETARD TABLET 15'S. While all medicines can cause side effects, not everyone experiences them.

  • Headache
  • Peripheral edema
  • Dizziness
  • Fatigue
  • Constipation
  • Swelling, particularly of the ankles and legs

Safety Advice for NICARDIA 20MG RETARD TABLET 15'SArrow

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Heart and circulation

Specialist supervision advised

Nicardia Retard 20 affects the cardiovascular system and should be used with particular caution in patients with certain heart conditions, such as severe aortic stenosis, unstable angina, recent myocardial infarction, or advanced heart failure.

Dosage of NICARDIA 20MG RETARD TABLET 15'SArrow

  • Always take NICARDIA 20MG RETARD TABLET 15'S exactly as your doctor has told you. It's very important to swallow the tablet whole with a glass of water. Do not break, crush, chew, or open the tablet, as this can affect how the medicine is released in your body and its effectiveness. Your doctor will determine the right dose and how long you need to take this medicine based on your specific health condition, age, and body weight. Try to take your medicine at the same time each day to help you remember. You can usually take it with or without food. Never stop taking NICARDIA 20MG RETARD TABLET 15'S on your own, even if you start feeling better, unless your doctor specifically instructs you to do so. Suddenly stopping the medication can be harmful. If you miss a dose, take it as soon as you remember, unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not double your dose to make up for a missed one. Always consult your doctor if you have any questions about taking this medicine.

How to store NICARDIA 20MG RETARD TABLET 15'S?Arrow

  • Keep NICARDIA RETARD 20MG TAB 1X15 away from the reach of children and pets.
  • Store NICARDIA RETARD 20MG TAB 1X15 at room temperature.

Benefits of NICARDIA 20MG RETARD TABLET 15'SArrow

  • NICARDIA 20MG RETARD TABLET 15'S is a medication that helps manage high blood pressure. It works by targeting tiny channels in your body's cells that allow calcium to enter. Specifically, it blocks these calcium channels in the muscle cells surrounding your blood vessels and, to some extent, in your heart muscle. Calcium is essential for muscle cells to contract. By blocking its entry, NICARDIA 20MG RETARD TABLET 15'S prevents these muscle cells from tightening up too much. When the muscle cells in your blood vessel walls relax, the blood vessels widen (this is called vasodilation). Wider blood vessels offer less resistance to blood flow, allowing blood to circulate more easily throughout your body. This reduced resistance directly leads to a decrease in your blood pressure. Additionally, the effect on heart muscle can help the heart pump more efficiently by slightly reducing its workload. In essence, this tablet eases the pressure on your circulatory system, making it a valuable tool in controlling hypertension.

How to use NICARDIA 20MG RETARD TABLET 15'SArrow

  • Always take NICARDIA 20MG RETARD TABLET 15'S exactly as your doctor has prescribed. It is crucial to follow their instructions precisely. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet in any way, as this medicine is designed for a slow release of the active ingredient over time, and altering it can change how your body absorbs the medication.
  • Your doctor will carefully determine the correct dose and the length of time you should take this medicine. This decision is highly personalised and depends on factors such as your age, body weight, medical condition, and how you respond to the treatment. Try to take your dose at the same time every day to establish a routine and help you remember.
  • It is very important that you do not stop taking NICARDIA 20MG RETARD TABLET 15'S on your own, even if you start to feel better. Always consult your doctor before making any changes to your treatment plan or stopping the medication. They will advise you on the safest way to discontinue the tablet if it is deemed appropriate.

FAQs

What are the possible side effects of Nicardia Retard 20mg Tablet that I should be aware of?Arrow

Yes, side effects of Nicardia Retard 20mg Tablet may include severe allergic reactions and liver or kidney problems. You must seek medical attention if you encounter any side effects, such as swelling, difficulty breathing, nausea, and rashes.

Does Nicardia Retard 20mg Tablet cause edema?Arrow

The vasodilation of Nicardia Retard 20mg Tablet can lead to an increased chance of fluid leakage from the blood vessels into the surrounding tissues, resulting in edema. It occurs in the lower extremities, such as the ankles and feet. It's important to monitor for signs of edema while taking this drug and inform your healthcare provider if you notice any unusual swelling or changes in your extremities.

How long does it take time for Nicardia Retard 20mg Tablet to work?Arrow

Immediate-release tablets of Nicardia Retard 20mg Tablet typically start working within 30 minutes to 1 hour after administration. Extended-release formulations may take longer to reach their maximum effect, with onset times ranging from 1 to 2 hours.

Can Nicardia Retard 20mg Tablet be given sublingually?Arrow

No, Nicardia Retard 20mg Tablet should not be given sublingually (under the tongue). It is available in various formulations, including immediate-release tablets and extended-release capsules, which are meant to be swallowed whole with water.

How does Nicardia Retard 20mg Tablet work in treating low blood pressure?Arrow

Nicardia Retard 20mg Tablet works by blocking the influx of calcium ions into certain cells, leading to relaxation and dilation of blood vessels, which mainly helps to lower blood pressure and improve blood flow.

Can I take Nicardia Retard 20mg Tablet with low BP?Arrow

If you have low blood pressure (hypotension), taking Nicardia Retard 20mg Tablet may further decrease your blood pressure and cause symptoms such as dizziness, lightheadedness, fainting, or fatigue. Therefore, taking this drug if you have low blood pressure is generally not recommended unless specifically prescribed and closely monitored by your healthcare provider.

What are the uses of Nicardia 20mg Retard Tablet?Arrow

Nicardia 20mg Retard Tablet is primarily used to manage high blood pressure (hypertension) and to prevent angina (heart-related chest pain). It helps in reducing the risk of heart attacks and strokes by improving blood flow and decreasing the workload on the heart.

What are the common side effects of Nicardia 20mg Retard Tablet?Arrow

Common side effects include dizziness, headache, swelling of ankles or feet, fatigue, palpitations, flushing, and constipation. These effects are usually mild and tend to resolve over time.

What is Nicardia Retard 20 used for?Arrow

Nicardia Retard 20 contains nifedipine, a calcium channel blocker, and is mainly used to treat high blood pressure (hypertension) and chronic stable angina (chest pain due to reduced blood flow to the heart). By relaxing blood vessels, it lowers blood pressure and improves blood flow to the heart muscle, helping to prevent angina episodes and reduce cardiovascular risk. In some cases, specialists may also use nifedipine for conditions involving blood vessel spasm, such as Raynaud’s phenomenon, but such uses are individualized and off-label.

How does Nicardia Retard 20 work in the body?Arrow

Nicardia Retard 20 contains nifedipine, which blocks L-type calcium channels in the smooth muscle of blood vessel walls. This reduces calcium entry into cells, leading to relaxation and dilation of arteries. As a result, peripheral vascular resistance falls, blood pressure decreases, and the heart’s workload is reduced. In coronary arteries, this vasodilation improves blood flow to the heart muscle, helping to prevent angina. The modified-release formulation provides a gradual, sustained release of nifedipine, leading to more stable blood levels and smoother blood pressure control over the dosing interval.

Can Nicardia Retard 20 be used for emergency high blood pressure or acute chest pain?Arrow

Nicardia Retard 20 is not intended for emergency treatment of very high blood pressure or for rapid relief of acute angina or chest pain. It is a modified-release preparation designed for long-term control and prevention. In acute situations such as hypertensive emergencies, suspected heart attack, or sudden severe chest pain, immediate medical attention is required and other fast-acting treatments are used. Patients should follow their doctor’s instructions for managing acute symptoms and should not rely on Nicardia Retard 20 for immediate relief.

How and when should I take Nicardia Retard 20?Arrow

Nicardia Retard 20 should be taken exactly as prescribed by your doctor, usually once or twice daily depending on your individual treatment plan. The tablet should be swallowed whole with a glass of water and must not be crushed, chewed, or split, as this can disrupt the modified-release mechanism and alter drug exposure. It is generally recommended to take it at the same time each day to maintain consistent blood levels. It may be taken with or without food, but you should follow any specific instructions from your prescriber and avoid making changes without medical advice.

What are the common side effects of Nicardia Retard 20?Arrow

Common side effects of Nicardia Retard 20 include headache, flushing (warmth and redness of the face), dizziness or light-headedness, fatigue, palpitations (awareness of heartbeat), and ankle or leg swelling (peripheral edema). Some people may also experience nausea, heartburn, or mild gastrointestinal discomfort. These effects are often dose-related and may lessen as the body adjusts to treatment. However, if side effects are persistent, severe, or worrying, you should contact your healthcare provider. Sudden worsening chest pain, fainting, or marked shortness of breath require urgent medical evaluation.

Is Nicardia Retard 20 safe for long-term use?Arrow

Nicardia Retard 20 is commonly used as a long-term therapy for chronic hypertension and angina when prescribed and monitored appropriately. Long-term use has been well studied for nifedipine in modified-release forms. Regular follow-up is important to assess blood pressure control, angina frequency, side effects, and any changes in kidney function, heart function, or other comorbidities. Your doctor may adjust your treatment over time, add other medicines, or change therapy based on your response. Do not stop long-term treatment abruptly without medical advice, as this may destabilize blood pressure or angina control.

Can I drink grapefruit juice while taking Nicardia Retard 20?Arrow

Grapefruit and grapefruit juice can inhibit the CYP3A4 enzyme in the gut wall, which is involved in the metabolism of nifedipine. This interaction can increase nifedipine blood levels and may enhance its blood pressure-lowering effect and side effects, such as dizziness, flushing, or low blood pressure. Therefore, it is generally advisable to avoid grapefruit or grapefruit juice while taking Nicardia Retard 20. Other citrus fruits such as orange typically do not have this interaction, but you should follow your doctor’s dietary advice.

Can Nicardia Retard 20 be taken with other blood pressure medicines?Arrow

Nicardia Retard 20 is often used in combination with other antihypertensive medicines, such as ACE inhibitors, angiotensin receptor blockers, diuretics, or beta-blockers, to achieve better blood pressure control. However, combining multiple blood pressure-lowering agents can increase the risk of hypotension, dizziness, or fainting, especially when treatment is initiated or doses are changed. Your doctor will select appropriate combinations and monitor your response. You should inform your healthcare provider about all medicines you are taking and report any symptoms of excessive blood pressure lowering, such as severe dizziness or near-fainting.

What should I do if I miss a dose of Nicardia Retard 20?Arrow

If you miss a dose of Nicardia Retard 20, take it as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects such as low blood pressure, dizziness, or palpitations. If you frequently forget doses, discuss strategies with your healthcare provider to improve adherence.

Who should not take Nicardia Retard 20?Arrow

Nicardia Retard 20 should generally not be used in people with known hypersensitivity to nifedipine or any component of the formulation. It is usually avoided or used with great caution in patients with severe aortic stenosis, cardiogenic shock, unstable angina, or recent myocardial infarction, unless specifically advised by a cardiologist. It may also be unsuitable in certain severe heart failure states. Patients with significant liver impairment, very low baseline blood pressure, or those taking strong CYP3A4 inhibitors or inducers require careful assessment and dose adjustment. Always inform your doctor about your full medical history before starting therapy.

Can Nicardia Retard 20 be used during pregnancy or breastfeeding?Arrow

Use of Nicardia Retard 20 during pregnancy or breastfeeding requires individualized risk–benefit assessment by a specialist. Nifedipine has been used in pregnancy for specific indications such as hypertension or preterm labor under specialist supervision, but it is not universally considered first-line for all pregnant patients. During breastfeeding, small amounts of nifedipine may pass into breast milk. The decision to use Nicardia Retard 20 in pregnant or breastfeeding women should be made by the treating physician, taking into account the severity of the mother’s condition, alternative options, and available safety data.

References

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Morningside Healthcare Ltd, Electronic medicines compendium (EMC),

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Package leaflet: Information for the user - Nifedipine. www.hpra.ie. Available at:

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Nifedipine (oral route). Mayo Clinic. Published 2025. Accessed April 26, 2025. ‌

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Ratings & Review

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Reviewed on 05-12-2022

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Good representation and good communication to the cx very helpfull

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Reviewed on 09-01-2024

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