NICEF AZ TABLET 10'S

How NICEF AZ TABLET 10'S Works

• NICEF AZ TABLET 10'S is a combination medication designed to combat a variety of infections by targeting different mechanisms within the body. It contains two active ingredients: Nimesulide and Azithromycin. Understanding how each of these components works is crucial to appreciating the overall effectiveness of the tablet.
• Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) that primarily functions by inhibiting the cyclooxygenase (COX) enzymes. There are two main COX enzymes, COX-1 and COX-2. Nimesulide selectively inhibits COX-2, which is primarily responsible for the production of prostaglandins at sites of inflammation. Prostaglandins are hormone-like substances that contribute to pain, fever, and inflammation. By reducing prostaglandin synthesis, Nimesulide effectively alleviates these symptoms, providing relief from pain, reducing fever, and decreasing inflammation associated with various conditions. Nimesulide's preferential COX-2 inhibition is thought to result in a lower risk of gastrointestinal side effects compared to non-selective NSAIDs.
• Azithromycin, on the other hand, is a macrolide antibiotic that targets bacterial infections. It works by inhibiting bacterial protein synthesis. Specifically, Azithromycin binds to the 50S ribosomal subunit of bacteria, which is essential for the translation of mRNA into proteins. By binding to this subunit, Azithromycin prevents the addition of new amino acids to the growing polypeptide chain, effectively halting protein synthesis. Without the ability to produce proteins, bacteria cannot grow, replicate, or perform essential functions, ultimately leading to their death or inhibited growth. Azithromycin is effective against a wide range of bacteria, including gram-positive and gram-negative bacteria, as well as certain atypical bacteria.
• The combined action of Nimesulide and Azithromycin in NICEF AZ TABLET 10'S provides a dual approach to fighting infections. Nimesulide addresses the inflammatory response associated with the infection, providing symptomatic relief, while Azithromycin directly targets and eliminates the bacteria causing the infection. This combination can be particularly useful in situations where inflammation exacerbates the symptoms of a bacterial infection. The user gets relief from the infection faster due to anti-inflammatory action of Nimesulide and antimicrobial action of Azithromycin.

Common side effects of NICEF AZ Tablet may include nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhea. Some individuals might experience headache, dizziness, drowsiness, or fatigue. Skin reactions like rash or itching are also possible. Less common side effects include changes in liver function tests, jaundice (yellowing of skin or eyes), dark urine, pale stools, unusual bleeding or bruising, and allergic reactions (swelling of the face, lips, tongue, or throat, difficulty breathing). In rare cases, serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), blood disorders, or liver failure may occur. Consult your doctor if you experience any persistent or severe side effects.

• If you miss a dose of NICEF AZ Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep NICEF AZ TAB 1X10 away from the reach of children and pets.
• Store NICEF AZ TAB 1X10 at room temperature.

• Take NICEF AZ TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking it without consulting them, even if you feel better. This helps ensure the infection is fully treated and prevents antibiotic resistance.
• It's best to take NICEF AZ TABLET 10'S at the same time each day. This helps maintain a consistent level of the medication in your body, maximizing its effectiveness. You can set a daily reminder to help you remember.
• NICEF AZ TABLET 10'S can be taken with or without food, but taking it with food may reduce stomach upset. If you experience nausea, vomiting, or diarrhea, try taking it with a small snack.
• Complete the full course of NICEF AZ TABLET 10'S as prescribed, even if your symptoms improve within a few days. Prematurely stopping the medication can lead to a recurrence of the infection and the development of resistant bacteria.
• Inform your doctor about all other medications, supplements, and herbal products you are taking before starting NICEF AZ TABLET 10'S. Some medications can interact with azithromycin, affecting its efficacy or increasing the risk of side effects. Specifically mention any antacids you are taking as they can interfere with absorption of Azithromycin. Wait for 2 hours before or after taking antacids.
• If you experience any severe side effects, such as difficulty breathing, rash, swelling, or persistent stomach problems, seek immediate medical attention. While side effects are usually mild, some can be serious and require prompt treatment.

• NICEF AZ TABLET 10'S can be taken with or without food. However, if you experience stomach upset, it's best to take it with food. Avoid consuming large amounts of grapefruit juice while taking this medicine, as it may increase the drug's concentration in your body.