NITROGESIC OINTMENT 30 GM

How NITROGESIC OINTMENT 30 GM Works

• NITROGESIC OINTMENT 30 GM is a topical medication primarily used for the relief of pain associated with anal fissures. Its effectiveness stems from the active ingredient glyceryl trinitrate (GTN), also known as nitroglycerin. Understanding how NITROGESIC OINTMENT works involves considering the physiological mechanisms underlying anal fissures and the pharmacological actions of GTN.
• Anal fissures are small tears in the lining of the anus, typically caused by the passage of hard or large stools. These tears lead to pain, bleeding, and spasm of the internal anal sphincter muscle. The sustained contraction of this muscle reduces blood flow to the anal region, impeding the healing process and perpetuating the pain cycle. NITROGESIC OINTMENT addresses this by promoting vasodilation – the widening of blood vessels – in the affected area.
• Glyceryl trinitrate (GTN) is a vasodilator, meaning it relaxes smooth muscles in blood vessel walls. When NITROGESIC OINTMENT is applied to the anal area, GTN is absorbed through the skin and converted to nitric oxide (NO). Nitric oxide is a potent vasodilator. It activates guanylate cyclase, an enzyme that increases the production of cyclic guanosine monophosphate (cGMP). Increased cGMP levels lead to the dephosphorylation of myosin light chains in smooth muscle cells, causing them to relax.
• The relaxation of the internal anal sphincter muscle induced by GTN has several beneficial effects. First, it increases blood flow to the fissure, delivering oxygen and nutrients necessary for tissue repair. This enhanced circulation accelerates the healing process. Second, the reduced muscle spasm alleviates pain. The pain associated with anal fissures is often exacerbated by the involuntary contraction of the sphincter muscle. By relaxing this muscle, NITROGESIC OINTMENT provides significant pain relief. Third, by reducing the pressure within the anal canal, GTN helps prevent further tearing and irritation, creating a more favorable environment for healing.
• In summary, NITROGESIC OINTMENT works by delivering glyceryl trinitrate (GTN) to the anal area, where it is converted to nitric oxide (NO). NO relaxes the internal anal sphincter muscle, increasing blood flow, reducing muscle spasm, and alleviating pain. This combined action promotes healing of the anal fissure and provides relief from associated symptoms. It's crucial to use NITROGESIC OINTMENT as directed by a healthcare professional to maximize its benefits and minimize potential side effects, such as headache, which can occur due to vasodilation in other parts of the body.

Like all medicines, Nitrogesic Ointment can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Headache * Dizziness * Flushing (redness of the skin) **Uncommon Side Effects (may affect up to 1 in 100 people):** * Increased heart rate * Low blood pressure * Contact dermatitis (skin rash or irritation at the application site) **Rare Side Effects (may affect up to 1 in 1,000 people):** * Fainting * Allergic reactions, including skin rash, itching, and swelling * Exfoliative Dermatitis **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Severe allergic reaction (anaphylaxis) with symptoms such as difficulty breathing, swelling of the face, lips, tongue or throat. **Other Potential Side Effects:** * Tolerance (reduced effect of the medicine with continued use) * Withdrawal symptoms (e.g., headache, dizziness) may occur if the medicine is stopped suddenly. **Important Information:** * If you experience any of these side effects or any other unusual symptoms, stop using Nitrogesic Ointment and consult your doctor or pharmacist immediately. * This is not a complete list of side effects, and others may occur. Please inform your doctor if you experience any troublesome symptoms while using this medicine.

• If you forget to apply NITROGESIC OINTMENT 30 GM at the scheduled time, apply it as soon as you remember. However, if it is almost time for your next application, skip the missed one and continue with your regular schedule. Do not apply a double dose to make up for the missed one.

• Keep NITROGESIC OINTMENT 30GM away from the reach of children and pets.
• Store NITROGESIC OINTMENT 30GM at room temperature.

• **Understanding Nitrogesic Ointment:** Nitrogesic Ointment contains glyceryl trinitrate (GTN), a vasodilator. It works by relaxing blood vessels, increasing blood flow to the applied area, and reducing pain associated with anal fissures. Always use it exactly as prescribed by your doctor to ensure optimal results and minimize potential side effects.
• **Proper Application Technique:** Before applying Nitrogesic, gently clean and dry the affected area. Use a small amount (about the size of a pea) and apply it thinly inside the anal canal as directed by your doctor. Avoid applying too much, as this can increase the risk of side effects such as headaches or dizziness. Wash your hands thoroughly after each application.
• **Managing Potential Side Effects:** Some users may experience headaches as a side effect of Nitrogesic. If headaches occur, they are usually mild and temporary. You can try taking an over-the-counter pain reliever like acetaminophen (paracetamol). If headaches are severe or persistent, consult your doctor. Dizziness or lightheadedness can also occur, so stand up slowly after applying the ointment. Do not drive or operate machinery if you feel dizzy.
• **Consistency is Key:** For best results, apply Nitrogesic Ointment consistently as prescribed, even if you start to feel better. It may take several weeks of regular use to fully heal the anal fissure. Do not stop using the ointment prematurely without consulting your doctor, as this could lead to a recurrence of the condition. Talk to your doctor if you don't see improvement after several weeks.
• **Lifestyle Adjustments for Enhanced Healing:** In addition to using Nitrogesic, consider making lifestyle adjustments to promote healing. Maintain a high-fiber diet, drink plenty of water, and avoid straining during bowel movements to prevent constipation. Regular exercise can also help improve bowel function. These measures can complement the effects of the ointment and contribute to faster and more complete healing of anal fissures. Consider using stool softeners if needed, and discuss with your doctor.

• While NITROGESIC OINTMENT 30 GM is a topical medication and is applied to the skin, it is unlikely to have any interactions with food. You can continue your normal diet while using this medication.