NORTIPAN DM CAPSULE 10'S

How NORTIPAN DM CAPSULE 10'S Works

• NORTIPAN DM CAPSULE 10'S is a combination medicine specifically designed to manage neuropathic pain associated with diabetic neuropathy. It contains Pregabalin and Nortriptyline, each working through distinct mechanisms to alleviate pain.
• Pregabalin, an active ingredient in NORTIPAN DM, is a structural analogue of gamma-aminobutyric acid (GABA), a naturally occurring inhibitory neurotransmitter in the brain. Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. By binding to this subunit, Pregabalin modulates the influx of calcium into nerve terminals. This reduction in calcium influx subsequently decreases the release of several excitatory neurotransmitters, including glutamate, noradrenaline, and substance P. These neurotransmitters are involved in the transmission of pain signals. By reducing their release, Pregabalin helps to dampen the overactive nerve signals that cause neuropathic pain.
• Nortriptyline, the other key component of NORTIPAN DM, belongs to a class of medications known as tricyclic antidepressants (TCAs). Nortriptyline primarily works by inhibiting the reuptake of norepinephrine and, to a lesser extent, serotonin in the synaptic cleft. Norepinephrine and serotonin are neurotransmitters that play a crucial role in mood regulation and pain modulation. By blocking their reuptake, Nortriptyline increases the concentration of these neurotransmitters in the synaptic cleft, allowing them to bind to their receptors for a more extended period. This potentiation of norepinephrine and serotonin activity helps to elevate mood and reduce the perception of pain.
• The synergistic action of Pregabalin and Nortriptyline in NORTIPAN DM provides comprehensive pain relief by targeting different aspects of neuropathic pain. Pregabalin addresses the overactivity of nerve signals by modulating calcium channel activity and reducing excitatory neurotransmitter release, while Nortriptyline modulates pain perception by increasing the availability of norepinephrine and serotonin. Together, they provide a balanced approach to pain management, improving the quality of life for individuals suffering from diabetic neuropathy.

Possible side effects of Nortipan DM Capsule may include: * Drowsiness * Dizziness * Headache * Nausea * Vomiting * Constipation * Dry mouth * Blurred vision * Difficulty urinating * Increased heart rate * Confusion * Restlessness * Tremors * Skin rash or itching * Swelling of the face, tongue, or throat (rare)

• If you miss a dose of Nortipan DM Capsule, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep NORTIPAN DM CAP 1X10 away from the reach of children and pets.
• Store NORTIPAN DM CAP 1X10 at room temperature.

• NORTIPAN DM CAPSULE 10'S does not typically have significant interactions with food. It can be taken with or without food as per your doctor's instructions. However, if you experience any stomach upset, taking it with food may help.
• Always follow your doctor's advice regarding the timing and administration of this medication.