NUCOXIA PG TABLET 10'S

How NUCOXIA PG TABLET 10'S Works

• NUCOXIA PG Tablet 10'S is a combination medication designed to alleviate neuropathic pain and improve overall comfort. It works through the synergistic action of its two active ingredients: Pregabalin and Etoricoxib. Understanding how each component functions is crucial to appreciating the overall therapeutic effect of this medication.
• Pregabalin, an anticonvulsant and analgesic, plays a key role in modulating pain signals within the nervous system. It primarily binds to the alpha2-delta subunit of voltage-gated calcium channels in nerve cells. By binding to this subunit, Pregabalin reduces the influx of calcium into the nerve terminals. This reduction subsequently inhibits the release of several excitatory neurotransmitters, such as glutamate, noradrenaline, and substance P. These neurotransmitters are heavily involved in the transmission of pain signals to the brain. By reducing their release, Pregabalin effectively dampens the pain signals, thereby providing relief from neuropathic pain. Unlike some other pain medications, Pregabalin does not directly act on opioid receptors, meaning it has a different mechanism of action and a lower risk of respiratory depression or addiction.
• Etoricoxib, a nonsteroidal anti-inflammatory drug (NSAID), belongs to a class of selective COX-2 inhibitors. Cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, are responsible for the production of prostaglandins. Prostaglandins are hormone-like substances that contribute to inflammation, pain, and fever. Traditional NSAIDs inhibit both COX-1 and COX-2 enzymes, which can lead to gastrointestinal side effects due to the inhibition of COX-1, which protects the stomach lining. Etoricoxib selectively inhibits the COX-2 enzyme, which is primarily involved in inflammation and pain. By selectively blocking COX-2, Etoricoxib reduces the production of prostaglandins at the site of inflammation and pain. This helps to reduce inflammation, swelling, and pain associated with conditions like osteoarthritis, rheumatoid arthritis, and acute pain. The selective COX-2 inhibition of Etoricoxib results in a lower risk of gastrointestinal side effects compared to non-selective NSAIDs.
• In combination, Pregabalin and Etoricoxib address neuropathic pain through distinct yet complementary mechanisms. Pregabalin targets the nerve signals themselves, reducing the intensity of pain transmission. Etoricoxib addresses the inflammatory component of pain by reducing prostaglandin production. This dual action makes NUCOXIA PG Tablet 10'S particularly effective in managing conditions where both nerve pain and inflammation are present. The combined effect often results in greater pain relief than either medication could achieve alone. It's important to take NUCOXIA PG Tablet 10'S as directed by your healthcare provider to ensure optimal therapeutic benefits and minimize potential side effects.

Like all medicines, NUCOXIA PG TABLET 10'S can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Nausea * Vomiting * Stomach pain * Diarrhea * Constipation * Gas * Heartburn * Headache * Dizziness * Fatigue * Swelling in the legs and ankles due to fluid retention (edema) * Increased blood pressure **Uncommon Side Effects (may affect up to 1 in 100 people):** * Loss of appetite * Changes in taste * Dry mouth * Anxiety * Depression * Difficulty sleeping * Numbness or tingling in the hands or feet * Tremors * Blurred vision * Ringing in the ears (tinnitus) * Irregular heartbeat * Palpitations * Shortness of breath * Cough * Nosebleeds * Skin rash * Itching * Sweating * Muscle cramps * Muscle pain * Joint pain * Back pain * Weakness * Weight gain **Rare Side Effects (may affect up to 1 in 1,000 people):** * Confusion * Hallucinations * Liver problems * Kidney problems * Severe allergic reactions (anaphylaxis) **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) **If you experience any of the following serious side effects, stop taking NUCOXIA PG TABLET 10'S and seek immediate medical attention:** * Chest pain * Severe stomach pain * Black or bloody stools * Vomiting blood * Swelling of the face, lips, or tongue * Difficulty breathing * Yellowing of the skin or eyes (jaundice)

• If you miss a dose of Nucoxia PG Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep NUCOXIA PG 75/60MG TAB 1X10 away from the reach of children and pets.
• Store NUCOXIA PG 75/60MG TAB 1X10 at room temperature.

• Take NUCOXIA PG Tablet 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting your healthcare provider. This medication is designed to manage specific conditions, and proper adherence is crucial for its effectiveness. It is important to understand that self-adjusting the dosage can lead to adverse effects or reduced therapeutic benefits. Always follow the instructions provided on the prescription label or as directed by your physician.
• NUCOXIA PG Tablet 10'S can be taken with or without food, but it's best to take it at the same time each day to maintain a consistent level of medication in your system. This consistency helps in achieving optimal pain relief and management of nerve-related symptoms. If you have a sensitive stomach, taking it with food might help reduce potential discomfort. However, it's essential to maintain a routine, so choose a method (with or without food) and stick to it.
• Inform your doctor about all other medications, supplements, or herbal products you are currently taking before starting NUCOXIA PG Tablet 10'S. Drug interactions can significantly impact the effectiveness of NUCOXIA PG Tablet 10'S or increase the risk of side effects. This includes over-the-counter medications and herbal remedies. A complete medication history helps your doctor make informed decisions about your treatment plan and adjust dosages if necessary to avoid harmful interactions.
• Be aware of potential side effects such as dizziness, drowsiness, nausea, or stomach upset while taking NUCOXIA PG Tablet 10'S. If these side effects persist or worsen, consult your doctor immediately. Avoid activities that require alertness, such as driving or operating machinery, until you know how the medication affects you. It's also important to monitor for any unusual symptoms and report them to your healthcare provider promptly.
• Store NUCOXIA PG Tablet 10'S in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets. Proper storage ensures the medication remains effective and safe for use. Do not store the medication in the bathroom, as the humidity can degrade its quality. Always check the expiration date before use and dispose of any expired medication according to local guidelines or your pharmacist's instructions. If you have any questions regarding storage, consult your pharmacist.
• If you miss a dose of NUCOXIA PG Tablet 10'S, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this can increase the risk of side effects. Maintaining a consistent dosing schedule is crucial for the medication's effectiveness, but if you frequently miss doses, discuss strategies for adherence with your doctor or pharmacist.

• NUCOXIA PG TABLET 10'S can be taken with or without food. However, taking it after food may reduce the risk of stomach upset. Avoid excessive consumption of alcohol while taking this medication as it can increase the risk of liver damage and other side effects. Consult your doctor for specific dietary advice.