NUCOXIA RELAX 90MG TABLET 10'S

How NUCOXIA RELAX 90MG TABLET 10'S Works

• NUCOXIA RELAX 90MG TABLET 10'S is a combination medicine designed to alleviate pain and relax muscles. It combines etoricoxib, a nonsteroidal anti-inflammatory drug (NSAID), and thiocolchicoside, a muscle relaxant. Understanding how each component works is crucial to appreciating the overall therapeutic effect.
• Etoricoxib, the NSAID component, functions by selectively inhibiting cyclooxygenase-2 (COX-2) enzymes. COX-2 is primarily responsible for producing prostaglandins at sites of inflammation and pain. Prostaglandins are lipid compounds that contribute to the inflammatory cascade, leading to pain, swelling, and fever. By selectively blocking COX-2, etoricoxib reduces prostaglandin production, thereby diminishing inflammation and alleviating pain. Unlike non-selective NSAIDs, etoricoxib has a lower propensity to inhibit COX-1, an enzyme that protects the stomach lining, potentially reducing the risk of gastrointestinal side effects.
• Thiocolchicoside, the muscle relaxant, operates through a different mechanism. It is believed to work primarily by acting on GABA-A receptors in the central nervous system. GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter that helps to reduce neuronal excitability. By enhancing GABAergic neurotransmission, thiocolchicoside helps to reduce muscle spasms and tension. Some studies also suggest that thiocolchicoside may act as a competitive GABA-A receptor agonist, further promoting muscle relaxation. Additionally, it exhibits anti-inflammatory and analgesic properties, which complement the effects of etoricoxib.
• The combined action of etoricoxib and thiocolchicoside in NUCOXIA RELAX provides comprehensive relief from pain and muscle stiffness. Etoricoxib addresses the inflammatory component of pain, while thiocolchicoside targets muscle spasms and tension. This synergistic effect allows for effective management of conditions characterized by musculoskeletal pain and inflammation, such as osteoarthritis, rheumatoid arthritis, and back pain. The muscle relaxant properties of thiocolchicoside also help improve mobility and reduce discomfort associated with muscle stiffness.
• In summary, NUCOXIA RELAX 90MG TABLET 10'S works through a dual mechanism: etoricoxib reduces inflammation and pain by inhibiting COX-2, while thiocolchicoside relaxes muscles by acting on GABA-A receptors and potentially possessing anti-inflammatory effects. This combination provides effective relief from pain, inflammation, and muscle spasms, improving overall patient comfort and mobility.

Like all medicines, NUCOXIA RELAX 90MG TABLET 10'S can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Stomach pain * Dry socket (pain after a tooth extraction) * Swelling of legs and/or feet due to fluid retention (oedema) * Dizziness * Headache * Palpitations (fast or irregular heartbeat) * Increased blood pressure * Wheezing or shortness of breath (bronchospasm) * Constipation * Wind (flatulence) * Gastritis (inflammation of the lining of the stomach) * Heartburn * Feeling sick (nausea) * Being sick (vomiting) * Oesophagitis (inflammation of the esophagus) * Mouth ulcers * Changes in blood test results related to your liver * Skin rash * Itching * Fluid retention * Elevated creatinine levels in blood tests * Flu-like illness **Uncommon side effects (may affect up to 1 in 100 people):** * Blurred vision * Ringing in the ears (tinnitus) * Sleepiness * Altered taste * Tremor * Cough * Indigestion (dyspepsia) * Weight gain * Anxiety * Depression * Mental Acuity decreased * Confusion * Hallucinations * Shortness of breath * Bleeding from the stomach or intestines * Inflammation of the bowel * Abnormal heart rhythm * Transient ischaemic attack (reduced blood flow to the brain) * Chest pain * Heart attack * Stroke * High blood pressure * Inflammation of blood vessels * Swelling * Serious allergic reactions (including hives, which may lead to trouble breathing or swallowing) * Muscle cramps/spasms * Muscle pain/tenderness * High level of potassium in your blood * Changes in your kidney or liver function * Low level of sodium in your blood * Irregular heart beat **Rare side effects (may affect up to 1 in 1,000 people):** * Angioedema (swelling of the face, lips, tongue, and/or throat, which may cause difficulty breathing or swallowing) * Hepatitis (inflammation of the liver) * Liver failure * Pancreatitis (inflammation of the pancreas) * Severe skin reactions (such as Stevens-Johnson syndrome or toxic epidermal necrolysis) which may be life-threatening * Upset Stomach

• If you miss a dose of Nucoxia Relax 90mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep NUCOXIA RELAX 90MG TAB 1X10 away from the reach of children and pets.
• Store NUCOXIA RELAX 90MG TAB 1X10 at room temperature.

• <b>Take Nucoxia Relax as Prescribed:</b> Always take Nucoxia Relax 90mg exactly as your doctor prescribes. Do not change the dosage or frequency without consulting them. This ensures the medication works effectively and minimizes potential side effects. Stick to the recommended treatment duration for optimal results.
• <b>Stay Hydrated:</b> Drink plenty of water throughout the day while taking Nucoxia Relax. Adequate hydration helps to reduce the risk of dehydration, which can exacerbate some side effects. Aim for at least 8 glasses of water daily, unless your doctor advises otherwise.
• <b>Monitor for Side Effects:</b> Be aware of potential side effects, such as stomach upset, headache, or dizziness. If you experience any persistent or severe side effects, contact your doctor immediately. Early reporting can help manage these issues effectively.
• <b>Avoid Alcohol:</b> Alcohol can interact with Nucoxia Relax and increase the risk of side effects, particularly stomach irritation. It's best to avoid alcohol consumption while taking this medication to minimize any potential complications and ensure the drug works as intended.
• <b>Inform Your Doctor About Other Medications:</b> Before starting Nucoxia Relax, inform your doctor about all other medications, supplements, and herbal products you are taking. This includes over-the-counter drugs. This helps prevent potential drug interactions that could affect the efficacy of Nucoxia Relax or increase the risk of side effects. Certain medications can interact with etoricoxib or tizanidine, affecting their effectiveness or increasing the risk of adverse effects. Your doctor can adjust dosages or monitor you more closely to avoid problems.

• NUCOXIA RELAX 90MG TABLET 10'S can be taken with or without food. However, it is recommended to take it at a fixed time to maintain consistent levels of the medicine in your body. This will also help you remember to take it regularly. If you experience stomach upset, taking it with food might help.