OLKEM TRIO 12.5MG TABLET 10'S

How OLKEM TRIO 12.5MG TABLET 10'S Works

• OLKEM TRIO 12.5MG TABLET 10'S is a combination medication designed to manage high blood pressure (hypertension) effectively. It combines three active ingredients, each working through a different mechanism to lower blood pressure and reduce the risk of cardiovascular complications. These components are olmesartan, amlodipine, and hydrochlorothiazide.
• Olmesartan belongs to a class of drugs known as angiotensin II receptor blockers (ARBs). Angiotensin II is a naturally occurring hormone that causes blood vessels to constrict, leading to increased blood pressure. Olmesartan works by blocking the action of angiotensin II, thereby preventing the blood vessels from narrowing. This allows the blood vessels to relax and widen, resulting in lower blood pressure. By selectively blocking the AT1 receptor, olmesartan effectively reduces the vasoconstrictor and aldosterone-secreting effects of angiotensin II.
• Amlodipine is a calcium channel blocker. It functions by inhibiting the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. In vascular smooth muscle, this calcium channel blockade causes relaxation of the arterial smooth muscle, leading to vasodilation (widening of blood vessels). This vasodilation reduces peripheral vascular resistance, which in turn lowers blood pressure. Amlodipine primarily affects arteries, reducing the afterload on the heart, which is the resistance the heart must overcome to pump blood. This makes it easier for the heart to pump blood efficiently.
• Hydrochlorothiazide is a thiazide diuretic, often referred to as a 'water pill.' It works by increasing the excretion of sodium and water from the body through the kidneys. This is achieved by inhibiting sodium reabsorption in the distal convoluted tubules of the nephron, a functional unit of the kidney. As sodium and water are excreted, the volume of blood circulating in the body decreases. This reduction in blood volume directly contributes to lowering blood pressure. Additionally, hydrochlorothiazide has a long-term effect of reducing peripheral vascular resistance, further aiding in blood pressure control. This diuretic effect also helps to reduce edema or fluid retention, which can be a common problem in people with hypertension.
• The synergistic action of these three components provides comprehensive blood pressure control. Olmesartan relaxes blood vessels by blocking angiotensin II, amlodipine widens blood vessels by blocking calcium channels, and hydrochlorothiazide reduces blood volume by increasing sodium and water excretion. This triple combination is particularly useful for patients who require multiple medications to achieve their target blood pressure levels. By addressing different pathways involved in blood pressure regulation, OLKEM TRIO 12.5MG TABLET 10'S offers a more effective and convenient approach to managing hypertension, ultimately reducing the risk of heart attack, stroke, and kidney problems.

Common side effects of Olkem Trio 12.5mg Tablet may include: Dizziness, Headache, Fatigue, Nausea, Vomiting, Diarrhea, Abdominal pain, Orthostatic hypotension (low blood pressure upon standing), Cough, Increased urination, Electrolyte imbalance (such as low potassium), Muscle cramps, and Changes in blood sugar levels. Less common but potentially serious side effects include: Allergic reactions (rash, itching, swelling), Kidney problems, Liver problems, Pancreatitis, and Vision changes. This is not an exhaustive list, and you should report any unusual symptoms to your doctor.

• If you miss a dose of OLKEM TRIO 12.5MG TABLET 10'S, take it as soon as you remember, unless it is close to the time for your next dose.
• In that case, skip the missed dose and continue with your regular dosing schedule.
• Do not double the dose to catch up.

• Keep OLKEM TRIO 12.5MG TAB 1X10 away from the reach of children and pets.
• Store OLKEM TRIO 12.5MG TAB 1X10 at room temperature.

• **Take consistently at the same time daily:** For optimal blood pressure control, take OLKEM TRIO 12.5MG TABLET 10'S at the same time each day. Consistency helps maintain steady medication levels in your body. This is especially important for a combination medication where consistent levels of all three components are needed for efficacy.
• **Monitor your blood pressure regularly:** Keep a log of your blood pressure readings at home and share it with your doctor. This helps them assess how well the medication is working and make any necessary adjustments to your treatment plan. Regular monitoring also helps detect any potential issues early on.
• **Stay hydrated:** Drink plenty of water throughout the day, unless advised otherwise by your doctor, especially if you experience dizziness. Adequate hydration supports healthy blood volume and can minimize potential side effects related to blood pressure changes. Aim for at least 8 glasses of water daily, adjusting for activity level and climate.
• **Be aware of potential side effects:** OLKEM TRIO 12.5MG TABLET 10'S can cause side effects like dizziness, lightheadedness, or changes in electrolyte levels. If you experience persistent or severe side effects, contact your doctor immediately. Understanding potential side effects empowers you to take appropriate action and ensure your safety.
• **Inform your doctor about all other medications and supplements:** Before starting OLKEM TRIO 12.5MG TABLET 10'S, inform your doctor about all other medications, supplements, and herbal remedies you are taking. Drug interactions can affect the effectiveness of OLKEM TRIO 12.5MG TABLET 10'S or increase the risk of side effects. A complete medication list helps your doctor make informed decisions about your treatment.