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Composition
Content Reviewed By:
Dr. Sanjay Mehta
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
Most side effects are temporary and resolve as your body adapts to the medication. If any side effects persist or cause concern, seek medical advice.

Heart and QT Prolongation
Monitor in patients at cardiac riskOndansetron can prolong the QT interval on the electrocardiogram in susceptible individuals, which may predispose to serious arrhythmias such as torsades de pointes.
ONDEM SYRUP 30 ML starts working within half an hour to 2 hours. It dissolves rapidly into the bloodstream and starts showing its effect.
The most common side effects of ONDEM SYRUP 30 ML are constipation, diarrhea, fatigue and headache. However, these are usually not bothersome and resolve on their own after some time. Consult your doctor if these persist or worry you.
No, ONDEM SYRUP 30 ML is an antiemetic and not a steroid. ONDEM SYRUP 30 ML is a selective 5-HT3 receptor antagonist. It is prescribed for the prevention and treatment of nausea and vomiting which is commonly observed after surgery or due to cancer chemotherapy.
No, ONDEM SYRUP 30 ML does not work for seasickness. This is because ONDEM SYRUP 30 ML has very little effect on the nausea associated with motion sickness.
The dosage of Ondem syrup for a child is calculated by a healthcare professional based on the child’s body weight (kg), age, the concentration of ondansetron in the specific syrup preparation, and the clinical indication (for example, vomiting due to gastroenteritis versus chemotherapy). Because product strengths and approved regimens vary between countries and brands, there is no single universal mg/kg dose that is safe to apply in all situations. The prescriber uses locally approved product information or clinical guidelines to calculate an appropriate mg/kg dose and then converts this into a volume in mL. Caregivers should follow the exact dose and frequency written on the prescription and should not attempt to calculate or adjust the dose themselves.
A single standard mg per kg dose for Ondem syrup cannot be provided safely because dosing depends on several factors: the exact ondansetron concentration in the syrup, the child’s age and weight, the underlying cause of nausea and vomiting, and local regulatory recommendations. Different indications, such as postoperative nausea or chemotherapy‑induced nausea, may have different dosing schedules and maximum daily doses. Providing a generic mg/kg figure without these details risks underdosing or overdosing. For this reason, only a doctor or paediatric specialist who has access to the specific product information and the child’s clinical details should determine the mg/kg dose.
Once a doctor has prescribed a specific volume of Ondem syrup, you should measure it using a calibrated oral syringe, dropper, or medicine cup supplied with the product or provided by the pharmacy. Do not use household teaspoons or tablespoons, as their volumes are inaccurate and can lead to dosing errors. Shake the bottle if the label instructs you to do so, draw up the exact volume in mL, and administer it slowly into the child’s mouth. If you are unsure how to measure the dose, ask your pharmacist to demonstrate. Never change the volume or frequency without medical advice, even if the child’s symptoms improve or worsen.
If your child vomits shortly after taking Ondem syrup, do not automatically repeat the dose. Whether a replacement dose is needed depends on how soon the vomiting occurred, the child’s condition, and the prescriber’s instructions. In some cases, if vomiting occurs within a few minutes, a doctor may advise repeating the dose; in others, they may recommend waiting until the next scheduled dose. Because repeating a dose can increase the risk of overdose, you should contact your doctor or pharmacist for specific guidance. If the child continues to vomit, appears dehydrated, or becomes unusually drowsy or irritable, seek urgent medical assessment.
The safety and dosing of ondansetron in infants and very young children depend on age, weight, indication, and local regulatory approvals. In some regions, ondansetron is not routinely recommended for very young infants or is restricted to specific hospital‑based indications. Because immature organ function, especially in the liver, can affect how the drug is processed, dosing in this age group requires particular caution. Ondem syrup should not be given to infants or toddlers without a clear prescription and supervision by a paediatrician. If a baby has persistent vomiting, immediate medical evaluation is required to rule out serious conditions such as intestinal obstruction, infection, or metabolic disorders.
Any adjustment of Ondem syrup dose based on changes in body weight should be made only by a healthcare professional. While weight is a key factor in mg/kg dosing, the prescriber also considers the indication, treatment duration, organ function, and maximum recommended daily dose. Parents should not recalculate or increase the dose on their own if they feel the child has grown or if symptoms are not fully controlled. Instead, they should inform the doctor of the child’s current weight and clinical response so that the regimen can be reviewed safely.
The duration of Ondem syrup therapy depends on the cause of vomiting and the doctor’s treatment plan. For many self‑limited conditions, such as mild viral gastroenteritis, ondansetron is often used for a short period, sometimes only one or a few doses, to help control vomiting and allow oral fluids to be tolerated. Prolonged or repeated use without medical review is not advisable, as it may mask worsening disease or lead to unnecessary exposure to side effects. If vomiting persists beyond the timeframe advised by your doctor, or if new symptoms develop, the child should be reassessed rather than continuing Ondem syrup indefinitely.
Commonly reported side effects of ondansetron, the active ingredient in Ondem syrup, include headache, constipation, diarrhoea, abdominal discomfort, and a sensation of flushing or warmth. Some children may experience dizziness or fatigue. These effects are usually mild and transient. Rare but more serious adverse effects include changes in heart rhythm (such as QT interval prolongation), severe allergic reactions, and serotonin syndrome when combined with other serotonergic medicines. If your child develops palpitations, fainting, severe rash, breathing difficulty, or marked restlessness and agitation, stop the medicine and seek urgent medical care. Always inform the doctor about any other medicines or supplements the child is taking.
Ondem syrup is sometimes prescribed to help control vomiting so that a child can better tolerate oral rehydration solution (ORS) during gastroenteritis. When used under medical guidance, the two can be given together, with ondansetron administered as prescribed and ORS offered in small, frequent sips once vomiting is controlled. However, Ondem syrup should not replace proper rehydration or medical assessment. If the child shows signs of moderate or severe dehydration, blood in stool or vomit, high fever, or abdominal distension, they require prompt medical evaluation regardless of ondansetron use.
Using Ondem syrup without a prescription is not recommended. Although ondansetron is effective for certain types of nausea and vomiting, it is not a general remedy for all causes, and inappropriate use may delay diagnosis of serious conditions or expose the patient to unnecessary risks. For travel sickness, other medicines with specific approvals may be more appropriate. A doctor should evaluate the underlying cause of nausea, review the patient’s medical history and concomitant medicines, and then decide whether Ondem syrup is suitable, at what dose per kg, and for how long.
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•
Reviewed on 19-01-2024
(5/5)
ALKEM LABORATORIES LIMITED
Country of Origin -
India

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