PENTATE LS CAPSULE 10'S

How PENTATE LS CAPSULE 10'S Works

• PENTATE LS CAPSULE 10'S is a combination medication designed to manage symptoms related to gastroesophageal reflux disease (GERD) and peptic ulcers, particularly when these conditions are exacerbated by stress or anxiety. It contains three active ingredients: Pantoprazole, Levosulpiride, and a third ingredient often a sustained-release component to prolong the medication's effects.
• Pantoprazole, a proton pump inhibitor (PPI), is the primary component responsible for reducing stomach acid production. It works by irreversibly binding to the hydrogen-potassium ATPase enzyme system (the 'proton pump') located in the parietal cells of the stomach lining. These parietal cells are responsible for secreting hydrochloric acid, which is essential for digestion but can also contribute to the irritation and erosion of the esophageal and gastric lining in GERD and ulcers. By blocking the proton pump, pantoprazole effectively inhibits the final step in acid production, leading to a significant and sustained decrease in gastric acidity. This reduced acidity helps to alleviate symptoms such as heartburn, acid regurgitation, and difficulty swallowing. It also creates an environment conducive to the healing of damaged tissues in the esophagus and stomach.
• Levosulpiride, the second active ingredient, is a prokinetic and antiemetic agent. It primarily works by selectively blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and the gastrointestinal tract. The CTZ is located in the brain and is involved in triggering nausea and vomiting. By blocking dopamine receptors in this area, Levosulpiride helps to reduce feelings of nausea and the urge to vomit. In the gastrointestinal tract, Levosulpiride enhances the release of acetylcholine, a neurotransmitter that stimulates gut motility. This increased motility accelerates gastric emptying, reduces the amount of time that food and acid remain in the stomach, and promotes the movement of food through the digestive system. By improving gastric emptying and reducing esophageal exposure to stomach acid, Levosulpiride complements the acid-suppressing effects of pantoprazole.
• The sustained-release component in PENTATE LS CAPSULE 10'S is designed to release pantoprazole gradually over an extended period. This allows for a more consistent level of the drug in the bloodstream and provides prolonged acid suppression. This is particularly beneficial for individuals who experience nocturnal acid breakthrough or require round-the-clock symptom control. The sustained-release mechanism ensures that the medication continues to work throughout the night, preventing acid-related discomfort and promoting uninterrupted sleep.
• In summary, PENTATE LS CAPSULE 10'S works through a multi-faceted approach: Pantoprazole reduces acid production, Levosulpiride improves gastric motility and reduces nausea, and the sustained-release mechanism provides prolonged symptom relief. This combination makes it an effective treatment option for GERD and peptic ulcers, particularly when stress and anxiety are contributing factors.
• It is important to note that while PENTATE LS CAPSULE 10'S can provide significant symptom relief, it is typically used in conjunction with lifestyle modifications, such as dietary changes, avoiding trigger foods, and maintaining a healthy weight. Additionally, long-term use of PPIs like pantoprazole may be associated with certain risks, such as an increased risk of fractures and nutrient deficiencies, so it is essential to use this medication under the guidance of a healthcare professional.

Possible side effects of PENTATE LS CAPSULE 10'S may include: Headache, Dizziness, Nausea, Vomiting, Stomach pain, Diarrhea, Constipation, Flatulence, Dry mouth, Heartburn, Allergic reactions (rash, itching, swelling), Changes in taste, Difficulty sleeping (insomnia), Anxiety, Depression, Blurred vision, Muscle pain, Joint pain, Fatigue, Increased liver enzymes, and in rare cases, more severe reactions. Consult your doctor if you experience any persistent or severe side effects.

• If you miss a dose of PENTATE LS CAPSULE, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep PENTATE LS CAP 1X10 away from the reach of children and pets.
• Store PENTATE LS CAP 1X10 at room temperature.

• Take PENTATE LS CAPSULE 10'S exactly as prescribed by your doctor. Do not crush, chew, or open the capsule. Swallow it whole with a glass of water, preferably 30-60 minutes before a meal to maximize absorption. Consistent timing is key for optimal acid control.
• If you miss a dose of PENTATE LS CAPSULE 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up, as this can increase the risk of side effects. Always maintain the prescribed interval between doses.
• Inform your doctor about all other medications, supplements, or herbal products you are currently taking before starting PENTATE LS CAPSULE 10'S. This is crucial to avoid potential drug interactions that could affect the medication's effectiveness or increase the risk of adverse effects. Pay special attention to medications like blood thinners, antifungals, and certain heart medications.
• PENTATE LS CAPSULE 10'S is generally well-tolerated, but some people may experience side effects such as headache, diarrhea, nausea, or abdominal pain. If these side effects persist or worsen, consult your doctor promptly. More serious side effects are rare but require immediate medical attention.
• While taking PENTATE LS CAPSULE 10'S, consider lifestyle adjustments to further manage your acid reflux or peptic ulcer symptoms. These may include avoiding trigger foods (such as spicy, fatty, or acidic foods), limiting alcohol and caffeine intake, quitting smoking, and maintaining a healthy weight. Elevating the head of your bed can also help prevent nighttime acid reflux.

• PENTATE LS CAPSULE 10'S should be taken on an empty stomach, preferably 30 minutes before a meal.
• Avoid consuming alcohol while taking this medication, as it may increase the risk of side effects.
• Inform your doctor about any dietary supplements or herbal products you are taking, as they may interact with PENTATE LS CAPSULE 10'S.