PREALDONIL 75MG TABLET 10'S

How PREALDONIL 75MG TABLET 10'S Works

• PREALDONIL 75MG TABLET 10'S contains pregabalin, a medication primarily used to manage neuropathic pain and certain types of seizures. To understand how it works, it's essential to delve into its mechanism of action at the molecular level.
• Pregabalin is a structural analogue of gamma-aminobutyric acid (GABA), a naturally occurring inhibitory neurotransmitter in the brain. However, pregabalin does *not* directly bind to GABA receptors. Instead, its primary action involves binding to the alpha2-delta (α2δ) subunit of voltage-gated calcium channels (VGCCs) in the central nervous system (CNS). These calcium channels are critical for regulating the influx of calcium ions into nerve cells, a process vital for neurotransmitter release.
• By binding to the α2δ subunit, pregabalin modulates the function of these calcium channels. Specifically, it reduces the influx of calcium ions into nerve terminals. This reduction in calcium influx has a cascade of effects. Firstly, it diminishes the release of several excitatory neurotransmitters, including glutamate, noradrenaline, and substance P. These neurotransmitters are heavily involved in the transmission of pain signals and the hyperexcitability associated with seizures.
• In the context of neuropathic pain, which often arises from nerve damage or dysfunction, the over-release of excitatory neurotransmitters contributes significantly to the sensation of chronic pain. By dampening the release of these neurotransmitters, pregabalin helps to alleviate the pain signals, providing relief to individuals suffering from conditions like diabetic neuropathy, postherpetic neuralgia, and fibromyalgia.
• For individuals with seizure disorders, pregabalin's mechanism of action also proves beneficial. The excessive neuronal excitability that characterizes seizures is, in part, driven by the unrestrained release of excitatory neurotransmitters. By reducing the release of these neurotransmitters, pregabalin helps to stabilize neuronal activity and reduce the likelihood of seizures.
• Importantly, pregabalin's action is highly specific to the α2δ subunit of VGCCs. This selectivity minimizes the risk of widespread effects on other neuronal functions, contributing to its relatively favorable side effect profile compared to some other medications used for neuropathic pain and seizures. While pregabalin effectively manages symptoms, it's crucial to remember that it addresses the underlying cause of the nerve damage or seizure disorder. Therefore, it's often used as part of a comprehensive treatment plan that may include other therapies aimed at addressing the root cause of the condition.
• In summary, PREALDONIL 75MG TABLET 10'S, through its active ingredient pregabalin, reduces the release of excitatory neurotransmitters by binding to the α2δ subunit of voltage-gated calcium channels. This action helps to alleviate neuropathic pain and reduce the frequency of seizures, ultimately improving the quality of life for individuals suffering from these conditions. As with any medication, it is essential to use PREALDONIL 75MG TABLET 10'S under the guidance of a healthcare professional to ensure safe and effective use.

Common side effects of PREALDONIL 75MG TABLET may include: Dizziness, Drowsiness, Headache, Dry mouth, Blurred vision, Nausea, Vomiting, Constipation, Increased appetite, Weight gain, Swelling in extremities (edema), Difficulty concentrating, Memory problems, Tremors, Uncoordinated movement, Speech disorder, Fatigue, Weakness, Sleep disturbances (insomnia or excessive sleep), Changes in mood or behavior, such as irritability or anxiety. Less common but potentially serious side effects include: Allergic reactions (rash, itching, swelling, difficulty breathing), Muscle pain or weakness, Changes in vision, Decreased sexual desire or function, Suicidal thoughts, Seizures, Liver problems (yellowing of skin or eyes, abdominal pain), and Severe skin reactions (blistering, peeling). This is not an exhaustive list; other side effects may occur. Consult your doctor if you experience any unusual symptoms.

• If you miss a dose of PREALDONIL 75MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep PREALDONIL 75MG TAB 1X10 away from the reach of children and pets.
• Store PREALDONIL 75MG TAB 1X10 at room temperature.

• **Take PREALDONIL 75MG TABLET 10'S as prescribed by your doctor:** Always adhere to your doctor's instructions regarding dosage and duration. Do not self-medicate or alter the dosage without consulting your healthcare provider, even if you feel better.
• **Be aware of potential side effects:** PREALDONIL 75MG TABLET 10'S can cause side effects like dizziness, drowsiness, blurred vision, and weight gain. If you experience any persistent or troublesome side effects, inform your doctor immediately. Avoid driving or operating heavy machinery until you know how the medication affects you.
• **Inform your doctor about other medications and medical conditions:** Before starting PREALDONIL 75MG TABLET 10'S, disclose all other medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Also, inform your doctor about any pre-existing medical conditions, especially kidney problems, heart problems, or a history of substance abuse. This information is crucial for preventing potential drug interactions and ensuring safe usage.
• **Maintain a consistent routine:** Taking PREALDONIL 75MG TABLET 10'S at the same time(s) each day can help you remember to take it and maintain a consistent level of the medication in your body. This can improve its effectiveness in managing your condition. Use a pill organizer or set a reminder if needed.
• **Avoid alcohol while taking PREALDONIL 75MG TABLET 10'S:** Alcohol can increase the sedative effects of PREALDONIL 75MG TABLET 10'S, leading to excessive drowsiness, dizziness, and impaired coordination. It can also worsen some of the medication's side effects. Therefore, it is best to avoid alcohol consumption while on this medication. If you have any questions or concerns, consult your doctor or pharmacist.
• **Storage:** Store PREALDONIL 75MG TABLET 10'S at room temperature, away from direct sunlight, heat, and moisture. Keep it out of reach of children and pets. Do not store in the bathroom.
• **Dietary Considerations:** There are no specific dietary restrictions typically associated with PREALDONIL 75MG TABLET 10'S, but maintaining a healthy and balanced diet is always beneficial. If you experience weight gain as a side effect, discuss strategies for managing your diet with your doctor or a registered dietitian.