PREGADOC D 50MG/20MG CAPSULE 10'S

How PREGADOC D 50MG/20MG CAPSULE 10'S Works

• PREGADOC D 50MG/20MG CAPSULE 10'S is a combination medication designed to alleviate neuropathic pain and manage symptoms associated with certain neurological conditions. It contains two active ingredients: Pregabalin and Duloxetine, each contributing to its therapeutic effect through distinct mechanisms of action.
• Pregabalin, a structural analog of gamma-aminobutyric acid (GABA), exerts its analgesic and anticonvulsant effects by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding modulates calcium influx at nerve terminals, subsequently reducing the release of several neurotransmitters, including glutamate, norepinephrine, and substance P. By decreasing the release of these excitatory neurotransmitters, Pregabalin helps to dampen neuronal excitability and reduce the transmission of pain signals in the brain and spinal cord. Specifically, in the context of neuropathic pain, Pregabalin's action helps to stabilize overactive nerve cells and calm the heightened sensitivity that characterizes this condition. It is also effective in reducing the frequency of seizures in individuals with epilepsy.
• Duloxetine, on the other hand, is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It works by blocking the reabsorption (reuptake) of serotonin and norepinephrine in the synaptic cleft, the space between nerve cells. This action increases the concentration of these neurotransmitters in the synaptic cleft, allowing them to bind more effectively to their receptors on the receiving nerve cell. Serotonin and norepinephrine are crucial neurotransmitters involved in mood regulation, pain modulation, and overall mental well-being. By enhancing their availability, Duloxetine helps to improve mood, reduce anxiety, and alleviate pain. In the context of neuropathic pain, Duloxetine's action helps to restore the balance of neurotransmitters in the pain pathways, thereby reducing pain perception. It also plays a role in managing conditions like depression and anxiety, which often coexist with chronic pain syndromes.
• The synergistic effect of Pregabalin and Duloxetine in PREGADOC D 50MG/20MG CAPSULE 10'S provides comprehensive relief from neuropathic pain and associated symptoms. Pregabalin targets the overexcitability of nerve cells, while Duloxetine modulates the neurotransmitter balance in pain pathways and enhances mood regulation. Together, they address both the physical and psychological components of chronic pain, leading to improved quality of life for patients. The combination is particularly useful when pain is accompanied by mood disturbances or anxiety. It is important to use this medication under the guidance of a healthcare professional, who can assess the individual's condition and adjust the dosage as needed. Adherence to the prescribed treatment plan is essential for achieving optimal therapeutic outcomes and minimizing potential side effects.
• In summary, PREGADOC D 50MG/20MG CAPSULE 10'S offers a dual-action approach to managing neuropathic pain. Pregabalin reduces nerve excitability by modulating calcium channel activity, while Duloxetine enhances serotonin and norepinephrine levels to improve mood and reduce pain signaling. This combination provides a comprehensive strategy for alleviating chronic pain and improving overall well-being.

Common side effects of PREGADOC D 50MG/20MG CAPSULE may include: Dizziness, Sleepiness, Headache, Fatigue, Dry mouth, Blurred vision, Weight gain, Constipation, Increased appetite, Difficulty in concentrating, Swelling of hands and feet, Tremor, Uncoordinated body movements, Memory impairment. Uncommon side effects may include: Changes in heart rate, Decreased blood pressure, Muscle pain, Joint pain, Back pain, Difficulty in urination, Sexual dysfunction, Changes in mood or behavior, Anxiety, Confusion, Agitation, Restlessness, Irritability, Increased sweating, Skin rash, Itching, Hair loss, Nausea, Vomiting, Diarrhea, Abdominal pain, Heartburn, Increased liver enzymes. Rare side effects may include: Severe allergic reactions (rash, itching, swelling, dizziness, difficulty breathing), Suicidal thoughts, Liver problems, Muscle damage, Vision changes.

• If you miss a dose of PREGADOC D 50MG/20MG CAPSULE 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep PREGADOC D 50/20MG CAP 1X10 away from the reach of children and pets.
• Store PREGADOC D 50/20MG CAP 1X10 at room temperature.

• Take PREGADOC D 50MG/20MG CAPSULE 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. It is typically prescribed for managing neuropathic pain and may also address symptoms of anxiety associated with the pain.
• PREGADOC D combines pregabalin and duloxetine. Pregabalin helps manage nerve pain by reducing the abnormal electrical activity in the brain, while duloxetine, an antidepressant, helps improve mood and reduce pain signals.
• Be aware of potential side effects. Common side effects include drowsiness, dizziness, dry mouth, constipation, and weight gain. If these persist or worsen, inform your doctor immediately. More serious side effects, though rare, require immediate medical attention.
• Avoid alcohol while taking PREGADOC D. Alcohol can increase drowsiness and dizziness, which are common side effects of the medication, and may also interfere with the drug's effectiveness. Combining alcohol with PREGADOC D can also increase the risk of liver damage.
• If you have a history of liver or kidney problems, inform your doctor before starting PREGADOC D. The medication is metabolized by the liver and excreted by the kidneys, so dosage adjustments may be necessary to prevent complications. Regular monitoring of liver and kidney function might be needed.
• Do not stop taking PREGADOC D abruptly. Discontinuation can lead to withdrawal symptoms such as nausea, vomiting, anxiety, and difficulty sleeping. If you need to stop the medication, your doctor will gradually reduce the dosage to minimize these effects.
• It may take several weeks for PREGADOC D to start working effectively. Continue taking the medication as prescribed, even if you don't notice an immediate improvement in your symptoms. Consistent use is necessary to achieve the full therapeutic effect.
• Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements. PREGADOC D can interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects.
• Store PREGADOC D at room temperature, away from moisture and heat. Keep the medication in its original container and out of reach of children and pets. Dispose of unused medication properly; do not flush it down the toilet.
• If you experience any unusual changes in mood or behavior, especially suicidal thoughts, contact your doctor immediately. While duloxetine can improve mood, it can also, in rare cases, increase the risk of suicidal ideation, particularly in young adults.

• PREGADOC D 50MG/20MG CAPSULE 10'S can be taken with or without food. However, it is best to take it at a fixed time.