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Content Reviewed By:
Dr. Manoj Shah
, (MBBS)
Written By:
Ms. Priyanka Shah
, (B.Pharm)
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Cardiovascular and Thromboembolic Risk
Use with caution, avoid in high‑risk patientsProgestins like norethisterone may increase the risk of venous or arterial thromboembolic events, particularly in women with additional risk factors such as smoking, obesity, prolonged immobilization, or a personal or strong family history of thrombosis.
Yes, REGESTRONE CR 10MG TABLET 10'S may reset your cycle. It is usually given for about 10 days to help manage heavy periods. Usually, your periods will resume within 3 days after stopping the medication. Your body may correct itself after 3-4 cycles and your period cycle may resume as before.
Yes, REGESTRONE CR 10MG TABLET 10'S may cause breakthrough bleeding or spotting in some cases. This more likely occurs if the medicine is not taken as prescribed, such as taking lower than prescribed dose or not taking it 3 days before your periods start. It is, therefore, very important that you take REGESTRONE CR 10MG TABLET 10'S as prescribed.
REGESTRONE CR 10MG TABLET 10'S is advised to patients having heavy periods or prolonged periods. The usual dose is prescribed to be taken 3 times a day for 10 days. The bleeding will stop usually within 48 hours of taking it. However, consult your doctor if the bleeding continues.
Yes, you can get pregnant even if you are taking REGESTRONE CR 10MG TABLET 10'S. It is not a birth control pill. Therefore, you should use contraceptives or other birth control methods while you are on REGESTRONE CR 10MG TABLET 10'S. Consult the doctor if you have any other related concerns.
The dose and the number of days for which you need to take REGESTRONE CR 10MG TABLET 10'S will depend on the condition for which you are being treated and how well the medicine works for that condition. For example, when taken for endometriosis it is usually prescribed once daily for 6 to 9 months or until breakthrough bleeding becomes bothersome. When REGESTRONE CR 10MG TABLET 10'S is used to bring on a normal cycle in women who have stopped menstruating, it is usually supposed to be taken once a day for 5 to 10 days during the second half of the planned menstrual cycle. Always take the medicine exactly as advised by your doctor.
REGESTRONE CR 10MG TABLET 10'S is similar to the progesterone hormone naturally produced by the body. It helps in treating a variety of menstrual problems, such as heavy bleeding, amenorrhea (absence of periods) and irregular periods. Additionally, it is helpful in treating premenstrual syndrome where one experiences irritability, bloating, fatigue which occurs a few days before the period. REGESTRONE CR 10MG TABLET 10'S is also used to delay periods. Consult your doctor before starting REGESTRONE CR 10MG TABLET 10'S to avoid any complication.
For best results, take it strictly as per the advice of your doctor. The number of doses you take each day, and the number of days for which you take it depends on the medical problem being treated. However, it is recommended that you take it at the same time of each day. This will ensure consistent levels of medicine in your body.
If you forget a dose, take it as soon as you remember. You can continue taking the next scheduled tablets at their usual time. Do not take a double dose to make up for a forgotten dose. However, if you miss your dose often, you may experience frequent bleeding and spotting. Consult your doctor about it.
No, REGESTRONE CR 10MG TABLET 10'S has not been reported to cause miscarriage. However, it is advisable to consult your doctor before using any medicine during pregnancy.
Yes, REGESTRONE CR 10MG TABLET 10'S may reset your cycle. It is usually given for about 10 days to help manage heavy periods. Usually, your periods will resume within 3 days after stopping the medication. Your body may correct itself after 3-4 cycles and your period cycle may resume as before.
Regestrone is a brand of hormonal medicine containing norethisterone, a synthetic progestin. Progestins are man‑made forms of the natural hormone progesterone. Regestrone is used mainly in gynecology to manage menstrual and hormonal disorders such as irregular periods, heavy bleeding, and certain types of abnormal uterine bleeding. It works by stabilizing the uterine lining and modifying the hormonal environment of the reproductive system.
Regestrone is commonly prescribed for irregular menstrual cycles, heavy or prolonged menstrual bleeding (menorrhagia), abnormal uterine bleeding after structural causes have been excluded, painful periods (dysmenorrhea), and some cases of endometriosis to reduce pain and bleeding. It may also be used in specific protocols for premenstrual symptoms or to regulate cycles in women with anovulatory or dysfunctional uterine bleeding. The exact indication should be determined by a gynecologist after appropriate evaluation.
Regestrone (norethisterone) acts primarily on the endometrium, converting a proliferative lining into a secretory one and stabilizing it, which helps control irregular or heavy bleeding. At sufficient doses, it can suppress ovulation by inhibiting the release of pituitary gonadotropins. It also thickens cervical mucus, making it less favorable for sperm penetration. These combined effects help regulate menstrual cycles, reduce menstrual blood loss, and alleviate symptoms associated with hormonal imbalance or endometriosis.
Regestrone is a progestin and can have contraceptive effects at certain doses and regimens, but it is not typically used as a primary contraceptive in routine practice. Standard oral contraceptive pills contain specific combinations and doses of estrogen and/or progestin that are optimized for reliable pregnancy prevention. If contraception is your main goal, you should use a dedicated contraceptive method rather than relying on Regestrone prescribed for menstrual regulation or other indications. Always discuss contraceptive needs with your doctor.
Common side effects of Regestrone include headache, nausea, breast tenderness, abdominal bloating, mild weight changes, and mood changes such as irritability or low mood. Some women may experience breakthrough bleeding or spotting, changes in menstrual flow, or altered cycle length. Acne, fluid retention, and decreased libido can also occur in some individuals. These effects are usually mild to moderate, but if they are persistent, severe, or troubling, you should consult your doctor for reassessment of therapy.
Serious adverse effects with Regestrone are uncommon but can occur, particularly in women with pre‑existing risk factors. Progestins like norethisterone may increase the risk of thromboembolic events such as deep vein thrombosis, pulmonary embolism, or stroke, especially in women who smoke, are obese, are immobilized, or have a personal or strong family history of clotting disorders. Rarely, it may contribute to worsening of liver function or reveal hormone‑sensitive tumors. Sudden chest pain, shortness of breath, severe headache, visual changes, or unilateral leg pain or swelling require immediate medical attention.
Regestrone is generally contraindicated in women with known or suspected pregnancy (when used for non‑obstetric indications), active or previous thromboembolic disorders, severe liver disease or liver tumors, known or suspected hormone‑dependent malignancies such as breast or endometrial cancer, unexplained vaginal bleeding that has not been investigated, and known hypersensitivity to norethisterone or any component of the formulation. Caution is required in women with hypertension, diabetes with vascular involvement, migraine (especially with aura), obesity, or strong family history of thrombosis. A doctor should evaluate all risk factors before prescribing.
Regestrone is not recommended for routine use during pregnancy and should not be used to treat menstrual problems once pregnancy is confirmed. If you become pregnant while taking Regestrone, you should inform your doctor promptly; the medicine is usually discontinued unless there is a specific specialist‑guided indication. If you are trying to conceive, your doctor will weigh the benefits of short‑term use for cycle regulation against any potential impact on ovulation and timing of conception. Do not start or continue Regestrone in early pregnancy without explicit medical advice.
Norethisterone‑containing products, including Regestrone, are sometimes used under medical supervision to postpone menstruation for short periods, for example around important events. However, this is an off‑label or protocol‑specific use in many settings and should only be done after a doctor has assessed your medical history, risk of thrombosis, and potential contraindications. The timing of initiation and duration of use are critical and must be individualized. Self‑medication to delay periods without medical guidance is not advisable due to the risk of irregular bleeding and other adverse effects.
If you miss a dose of Regestrone, take it as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects such as nausea or breakthrough bleeding. If you frequently forget doses, inform your doctor, as inconsistent intake can reduce treatment effectiveness and cause irregular bleeding.
Yes, Regestrone can interact with certain medicines. Drugs that induce liver enzymes, such as some antiepileptics (for example, certain barbiturates, carbamazepine, phenytoin), rifampicin, rifabutin, some antiretrovirals, and herbal products like St John’s wort, may reduce norethisterone levels and decrease its effectiveness. Conversely, Regestrone may influence the metabolism of other hormones or anticoagulants in some cases. Always inform your doctor and pharmacist about all prescription medicines, over‑the‑counter products, and herbal supplements you are taking before starting Regestrone.
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