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REXIPRA PLUS TABLET 15'S

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REXIPRA PLUS TABLET 15'S

By INTAS PHARMACEUTICALS LIMITED

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193.59

₹164.55

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Content Reviewed By:

Dr. Sanjay Mehta

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About REXIPRA PLUS TABLET 15'S

  • Rexipra Plus Tablet is a prescription-only combination medicine that typically contains clonazepam and escitalopram oxalate. It is generally used under psychiatric supervision for the management of anxiety disorders, panic disorder, and depressive episodes associated with anxiety. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that helps correct serotonin imbalance in the brain, which can improve mood, reduce anxiety, and relieve associated physical symptoms such as tension and restlessness. Clonazepam is a benzodiazepine that enhances the effect of gamma-aminobutyric acid (GABA), a calming neurotransmitter, thereby reducing excessive neuronal activity and producing anxiolytic, sedative, and muscle-relaxant effects. This combination is usually considered when monotherapy with an antidepressant is insufficient or when rapid control of severe anxiety or panic symptoms is required at the start of treatment. Clonazepam generally provides short- to medium-term symptom relief, while escitalopram contributes to long-term stabilization of mood and anxiety. Because clonazepam is associated with risks of dependence, tolerance, and withdrawal, Rexipra Plus Tablet must be used strictly as directed by a qualified psychiatrist or physician, and it should not be stopped abruptly without medical guidance. Commonly reported side effects include drowsiness, dizziness, fatigue, slowed reaction time, impaired concentration, nausea, dry mouth, increased sweating, sexual dysfunction, and changes in sleep pattern. Some individuals may experience weight changes, gastrointestinal discomfort, or headache. Serious but less common adverse effects can include suicidal thoughts (especially in younger patients at the start of therapy or after dose changes), serotonin syndrome (characterized by agitation, confusion, sweating, tremor, and rapid heartbeat), severe allergic reactions, and significant changes in behavior such as agitation, aggression, or unusual impulsivity. Any sudden change in mood, behavior, or suicidal ideation requires urgent medical attention. Rexipra Plus Tablet can cause significant sedation and psychomotor impairment, so activities requiring alertness, such as driving or operating machinery, may be unsafe, particularly during the initial phase of treatment or after dose adjustments. The medicine can interact with alcohol, opioids, other benzodiazepines, certain antidepressants, antiepileptics, and drugs that affect serotonin levels, increasing the risk of excessive sedation, respiratory depression, or serotonin syndrome. It should be used with caution in people with liver or kidney impairment, respiratory disorders, a history of substance use disorder, bipolar disorder, seizure disorders, or glaucoma. Use during pregnancy and breastfeeding requires careful risk–benefit assessment by the treating clinician. Patients should attend regular follow-up visits so that response, side effects, and the need for ongoing clonazepam use can be reviewed, and tapering strategies can be planned when appropriate.

Uses of REXIPRA PLUS TABLET 15'S

  • Depression
  • Anxiety disorder
  • Panic disorder
  • Obsessive-compulsive disorder (OCD)
  • Social anxiety disorder (social phobia)

How REXIPRA PLUS TABLET 15'S Works

  • REXIPRA PLUS TABLET 15'S is a combination medicine primarily used to treat anxiety disorders. It combines two active ingredients: Escitalopram and Clonazepam. To understand how REXIPRA PLUS works, it's essential to consider the individual roles of these components.
  • Escitalopram belongs to a class of drugs called Selective Serotonin Reuptake Inhibitors (SSRIs). Serotonin is a neurotransmitter in the brain that plays a crucial role in regulating mood, emotions, and sleep. In individuals with anxiety disorders, serotonin levels might be imbalanced. Escitalopram works by selectively blocking the reabsorption (reuptake) of serotonin in the brain. This action increases the amount of serotonin available in the synaptic cleft (the space between nerve cells), enhancing its effects on nerve receptors. By increasing serotonin levels, Escitalopram helps to improve mood, reduce anxiety, and alleviate symptoms of depression often associated with anxiety disorders.
  • Clonazepam, on the other hand, is a benzodiazepine. It acts on the central nervous system by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter, meaning it reduces the activity of nerve cells in the brain. Clonazepam binds to GABA receptors, making them more responsive to GABA. This leads to a calming effect, reducing excessive neuronal excitability that contributes to anxiety. Clonazepam's action helps to quickly relieve symptoms like panic attacks, restlessness, and muscle tension.
  • In essence, REXIPRA PLUS combines an SSRI's long-term mood-stabilizing effect with a benzodiazepine's rapid anxiety relief. Escitalopram gradually addresses the underlying serotonin imbalance that contributes to anxiety, while Clonazepam provides immediate relief from acute anxiety symptoms. The combination helps manage both the psychological and physiological symptoms of anxiety disorders effectively.
  • It's crucial to remember that REXIPRA PLUS is typically prescribed for short-term use due to the potential for dependence with Clonazepam. The medication should be taken exactly as directed by a healthcare professional. Discontinuing the medicine abruptly can lead to withdrawal symptoms. A gradual tapering of the dose is usually recommended under medical supervision.
  • Furthermore, it's essential to discuss any existing medical conditions or other medications with your doctor before starting REXIPRA PLUS to avoid potential drug interactions or adverse effects. The medication can cause side effects like drowsiness, dizziness, and nausea. Driving or operating heavy machinery should be avoided until you know how REXIPRA PLUS affects you.

Side Effects of REXIPRA PLUS TABLET 15'SArrow

REXIPRA PLUS TABLET 15'S can cause several side effects, although not everyone experiences them. Common side effects may include nausea, dry mouth, constipation, increased sweating, blurred vision, dizziness, drowsiness, insomnia (difficulty sleeping), anxiety, agitation, decreased libido, and ejaculation problems. Less common but more serious side effects can include serotonin syndrome (symptoms include high fever, agitation, confusion, tremors, and rapid heart rate), neuroleptic malignant syndrome (symptoms include muscle rigidity, high fever, altered mental status, and autonomic dysfunction), seizures, abnormal bleeding or bruising, and allergic reactions (symptoms include rash, itching, swelling, and difficulty breathing). Other possible side effects are weight changes, changes in appetite, restlessness, muscle stiffness, movement disorders, orthostatic hypotension (drop in blood pressure upon standing), and changes in liver function tests. This is not an exhaustive list, and it is important to consult a doctor or pharmacist for a complete list and to report any unusual or persistent symptoms.

Safety Advice for REXIPRA PLUS TABLET 15'SArrow

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Other Medical Conditions and Drug Interactions

Use under strict supervision

Rexipra Plus Tablet should be used with particular caution in patients with a history of substance use disorder, respiratory depression, sleep apnoea, glaucoma, seizure disorders, or bipolar disorder.

Dosage of REXIPRA PLUS TABLET 15'SArrow

  • The recommended dosage of REXIPRA PLUS TABLET 15'S varies significantly depending on the individual's condition, its severity, and their response to the medication. It is crucial to adhere strictly to the dosage prescribed by your doctor. Typically, the starting dose is low and gradually increased to minimize potential side effects. The usual starting dose is one tablet a day, preferably in the morning or evening, as directed by your physician. The dosage may be adjusted based on your body's response to the medication.
  • For individuals with certain underlying conditions, such as liver or kidney problems, or elderly patients, the doctor may prescribe a lower dose to minimize the risk of adverse effects. It's important to inform your doctor about any pre-existing medical conditions or other medications you are currently taking to avoid any potential drug interactions. The dosage should be taken consistently at the same time each day to maintain a stable level of the medication in your body.
  • Do not abruptly stop taking REXIPRA PLUS TABLET 15'S, as this can lead to withdrawal symptoms. If you need to discontinue the medication, your doctor will gradually reduce the dosage over a period of time. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Regular monitoring by your physician is essential to ensure the medication is working effectively and to adjust the dosage as needed.
  • Take 'REXIPRA PLUS TABLET 15'S' only as per the prescription by your physician only

What if I miss my dose of REXIPRA PLUS TABLET 15'S?Arrow

  • If you miss a dose of Rexipra Plus Tablet 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How to store REXIPRA PLUS TABLET 15'S?Arrow

  • Keep REXIPRA PLUS TAB 1X15 away from the reach of children and pets.
  • Store REXIPRA PLUS TAB 1X15 at room temperature.

Benefits of REXIPRA PLUS TABLET 15'SArrow

  • REXIPRA PLUS TABLET 15'S is a combination medication primarily used to manage and alleviate symptoms associated with depression and anxiety disorders. Its dual-action formula provides a comprehensive approach to mental well-being, addressing multiple facets of these conditions.
  • Escitalopram, one of the active ingredients in REXIPRA PLUS, belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that plays a crucial role in regulating mood, sleep, appetite, and various other bodily functions. By preventing the reabsorption of serotonin, escitalopram helps to improve mood and reduce feelings of sadness and hopelessness often associated with depression.
  • Clonazepam, the other active ingredient, is a benzodiazepine. Benzodiazepines enhance the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits nerve activity in the brain. This action helps to reduce anxiety, promote relaxation, and alleviate symptoms such as panic attacks and excessive worry. Clonazepam's calming effect complements escitalopram's mood-enhancing properties, providing a balanced therapeutic effect.
  • The synergistic action of escitalopram and clonazepam in REXIPRA PLUS offers several key benefits. Firstly, it provides effective relief from symptoms of depression, including persistent sadness, loss of interest in activities, fatigue, and difficulty concentrating. By elevating serotonin levels, escitalopram helps to restore a sense of well-being and motivation.
  • Secondly, REXIPRA PLUS significantly reduces anxiety symptoms such as excessive worrying, restlessness, and irritability. Clonazepam's calming effect helps to alleviate these symptoms, promoting a sense of relaxation and emotional stability. This can be particularly beneficial for individuals experiencing panic disorder or generalized anxiety disorder.
  • Thirdly, the medication can improve sleep quality. Both depression and anxiety can disrupt sleep patterns, leading to insomnia or restless sleep. By reducing anxiety and promoting relaxation, clonazepam can help individuals fall asleep more easily and enjoy a more restful night's sleep.
  • Furthermore, REXIPRA PLUS can enhance overall quality of life. By effectively managing symptoms of depression and anxiety, it allows individuals to engage more fully in daily activities, improve their relationships, and experience a greater sense of fulfillment. It can also improve focus and concentration, making it easier to perform tasks at work or school.
  • REXIPRA PLUS is often prescribed when a single antidepressant or anti-anxiety medication is not sufficient to control symptoms. The combination of escitalopram and clonazepam can provide a more robust and comprehensive treatment approach, particularly for individuals with comorbid depression and anxiety.
  • It is important to note that REXIPRA PLUS should be taken under the guidance of a healthcare professional. The dosage and duration of treatment will depend on the individual's specific condition and response to the medication. It is also crucial to be aware of potential side effects and interactions with other medications.
  • In summary, REXIPRA PLUS TABLET 15'S offers a multifaceted approach to managing depression and anxiety disorders. By combining the mood-enhancing effects of escitalopram with the calming properties of clonazepam, it provides effective relief from a wide range of symptoms, improving overall mental well-being and quality of life.

How to use REXIPRA PLUS TABLET 15'SArrow

  • REXIPRA PLUS TABLET 15'S is an oral medication designed to alleviate symptoms of depression and anxiety disorders. Always adhere to your doctor's prescribed dosage and duration. It's typically taken once daily, with or without food, but consistency in timing is key for optimal results. Swallow the tablet whole; do not crush, chew, or break it, as this can affect how the medication is released and absorbed.
  • Before starting REXIPRA PLUS, inform your doctor about any pre-existing medical conditions, especially liver or kidney problems, glaucoma, or a history of seizures. Also, disclose all other medications you're taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential interactions. This is crucial because REXIPRA PLUS can interact with other drugs, potentially affecting their efficacy or increasing the risk of side effects.
  • It’s essential to understand that REXIPRA PLUS may take several weeks to show noticeable improvements in your symptoms. Continue taking the medication as prescribed, even if you don't feel immediate relief. Do not abruptly stop taking REXIPRA PLUS, as this can lead to withdrawal symptoms such as dizziness, nausea, and anxiety. If you need to discontinue the medication, your doctor will guide you on a gradual tapering schedule.
  • Be aware of potential side effects. Common side effects include nausea, dry mouth, constipation, and drowsiness. If these persist or worsen, consult your doctor. More serious side effects, though rare, can include changes in mood or behavior, suicidal thoughts, or allergic reactions. Seek immediate medical attention if you experience any severe side effects.
  • Store REXIPRA PLUS at room temperature, away from moisture and heat. Keep it out of reach of children. If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. Regular follow-up appointments with your doctor are important to monitor your progress and adjust your treatment plan as needed.

Quick Tips for REXIPRA PLUS TABLET 15'SArrow

  • Take REXIPRA PLUS TABLET 15'S exactly as prescribed by your doctor. Do not alter the dosage or stop taking the medicine without consulting them, as this can lead to withdrawal symptoms or a relapse of your condition. Consistency is key for optimal results.
  • REXIPRA PLUS TABLET 15'S can cause drowsiness or dizziness. Avoid driving, operating heavy machinery, or performing tasks that require alertness until you know how the medicine affects you. Your safety is paramount; prioritize activities accordingly.
  • Inform your doctor about all other medications, supplements, and herbal products you are currently taking before starting REXIPRA PLUS TABLET 15'S. Drug interactions can affect how the medicine works and increase the risk of side effects. A complete medical history ensures safer treatment.
  • Be patient with the treatment. It may take several weeks to experience the full benefits of REXIPRA PLUS TABLET 15'S. Continue taking the medicine as directed, even if you don't notice immediate improvement. Regular follow-ups with your doctor are important to monitor progress.
  • Store REXIPRA PLUS TABLET 15'S at room temperature, away from moisture and heat. Keep it out of reach of children and pets. Proper storage maintains the drug's efficacy and prevents accidental ingestion.

Food Interactions with REXIPRA PLUS TABLET 15'SArrow

  • REXIPRA PLUS TABLET 15'S can be taken with or without food, but it is best to take it at a fixed time. This medication does not have any specific food interactions, however, avoid taking it with alcohol as it may increase drowsiness.

FAQs

What is Rexipra Plus Tablet 15'S?Arrow

Rexipra Plus Tablet 15'S is a combination medicine used to treat anxiety and depression.

How does Rexipra Plus Tablet 15'S work?Arrow

Rexipra Plus Tablet 15'S works by increasing the levels of chemical messengers in the brain that help regulate mood.

What are the common side effects of Rexipra Plus Tablet 15'S?Arrow

Common side effects of Rexipra Plus Tablet 15'S include nausea, vomiting, diarrhea, constipation, headache, and dizziness.

Can Rexipra Plus Tablet 15'S be taken with or without food?Arrow

Rexipra Plus Tablet 15'S can be taken with or without food.

Is Rexipra Plus Tablet 15'S safe for pregnant women?Arrow

The safety of Rexipra Plus Tablet 15'S for pregnant women has not been established. Therefore, it should only be used if clearly directed by a doctor.

Is Rexipra Plus Tablet 15'S safe for breastfeeding women?Arrow

Rexipra Plus Tablet 15'S may be excreted in breast milk. Therefore, breastfeeding women should consult their doctor before using it.

What is the recommended dosage of Rexipra Plus Tablet 15'S?Arrow

The recommended dosage of Rexipra Plus Tablet 15'S varies from person to person. Follow your doctor's instructions regarding dosage.

What happens if I miss a dose of Rexipra Plus Tablet 15'S?Arrow

If you miss a dose of Rexipra Plus Tablet 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Should Rexipra Plus Tablet 15'S be stopped suddenly?Arrow

No, Rexipra Plus Tablet 15'S should not be stopped suddenly. This can cause withdrawal symptoms. Always consult your doctor before discontinuing your medication.

Is it safe to drink alcohol while taking Rexipra Plus Tablet 15'S?Arrow

It is not recommended to drink alcohol while taking Rexipra Plus Tablet 15'S, as it can increase the side effects.

Is Rexipra Plus Tablet 15'S habit-forming?Arrow

No, Rexipra Plus Tablet 15'S is not a habit-forming medicine.

How to store Rexipra Plus Tablet 15'S?Arrow

Store Rexipra Plus Tablet 15'S at room temperature, away from heat and moisture.

What happens if I overdose on Rexipra Plus Tablet 15'S?Arrow

If you overdose on Rexipra Plus Tablet 15'S, contact a doctor immediately.

Can Rexipra Plus Tablet 15'S interact with other medications?Arrow

Yes, Rexipra Plus Tablet 15'S can interact with other medications. Therefore, it is important to tell your doctor about all of your medications before starting any new medicine.

Can Rexipra Plus Tablet 15'S cause weight gain?Arrow

Weight gain can occur in some people taking Rexipra Plus Tablet 15'S. Talk to your doctor if you are concerned about this.

What is Rexipra Plus Tablet used for?Arrow

Rexipra Plus Tablet is generally prescribed for the treatment of anxiety disorders, panic disorder, and depressive episodes associated with significant anxiety. It combines escitalopram, an SSRI antidepressant, with clonazepam, a benzodiazepine, to provide both long-term control of anxiety and mood symptoms and short-term relief from acute anxiety, tension, and panic attacks. The exact indication for an individual patient is determined by the treating psychiatrist or physician.

How does Rexipra Plus Tablet work in the body?Arrow

Rexipra Plus Tablet works through two active components. Escitalopram increases the availability of serotonin in the brain by selectively inhibiting its reuptake, which helps improve mood, reduce anxiety, and stabilize emotional symptoms over time. Clonazepam enhances the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, leading to reduced neuronal excitability and a calming effect. Together, they help control both psychological and physical symptoms of anxiety and panic.

How long does it take for Rexipra Plus Tablet to show benefit?Arrow

The calming effect of clonazepam may be noticed within hours to days of starting therapy, leading to early relief from severe anxiety or panic symptoms. However, the full antidepressant and anxiolytic effect of escitalopram usually develops gradually over 2 to 6 weeks, and in some patients even longer. It is important not to judge the effectiveness of the medicine too early and not to stop it on your own. Any concerns about lack of improvement should be discussed with the prescribing doctor.

Can I stop taking Rexipra Plus Tablet suddenly if I feel better?Arrow

Rexipra Plus Tablet should not be stopped abruptly without medical advice. Sudden discontinuation, especially of clonazepam, can lead to withdrawal symptoms such as anxiety rebound, irritability, insomnia, tremors, sweating, palpitations, and in severe cases seizures. Stopping escitalopram suddenly may cause dizziness, mood changes, flu-like symptoms, and sleep disturbances. Your doctor will usually recommend a gradual dose reduction over weeks to months to minimize withdrawal effects and reduce the risk of relapse.

What are the common side effects of Rexipra Plus Tablet?Arrow

Common side effects include drowsiness, dizziness, fatigue, slowed thinking or reaction time, impaired concentration, nausea, dry mouth, constipation or loose stools, increased sweating, decreased libido, and difficulty achieving orgasm. Some people may experience headache, weight changes, or sleep disturbances such as insomnia or excessive sleepiness. Many of these effects are mild and may lessen as the body adjusts, but persistent or troublesome symptoms should be reported to the treating clinician.

Is Rexipra Plus Tablet habit-forming or addictive?Arrow

The clonazepam component of Rexipra Plus Tablet carries a risk of dependence, especially with prolonged use, higher doses, or use in individuals with a history of substance use disorder. Dependence means that the body adapts to the medicine and withdrawal symptoms may occur if it is stopped suddenly. For this reason, the medicine should be used only as prescribed, for the shortest duration necessary, and under regular medical supervision. Escitalopram itself is not considered addictive, but it can cause discontinuation symptoms if stopped abruptly.

Can I drink alcohol while taking Rexipra Plus Tablet?Arrow

Alcohol should generally be avoided while taking Rexipra Plus Tablet. Both alcohol and clonazepam depress the central nervous system, and their combined effect can lead to excessive drowsiness, impaired coordination, slowed breathing, and increased risk of accidents. Alcohol may also worsen anxiety, depression, and sleep quality, counteracting the therapeutic benefits of escitalopram. If you have consumed alcohol accidentally or in small amounts, inform your doctor, especially if you feel unusually sedated or unwell.

Is Rexipra Plus Tablet safe during pregnancy?Arrow

Use of Rexipra Plus Tablet during pregnancy requires careful individual risk–benefit assessment. Escitalopram has been associated with potential risks such as neonatal adaptation syndrome and, rarely, persistent pulmonary hypertension of the newborn when used in late pregnancy. Benzodiazepines like clonazepam may cause neonatal sedation, respiratory depression, or withdrawal symptoms if used near delivery. Therefore, this medicine is generally avoided in pregnancy unless the potential benefit to the mother clearly outweighs the risks to the fetus, and it should only be used under specialist supervision.

Can I take Rexipra Plus Tablet while breastfeeding?Arrow

Both escitalopram and clonazepam can pass into breast milk. Escitalopram is usually present in low to moderate amounts, while clonazepam may cause sedation, poor feeding, or breathing difficulties in the nursing infant, particularly with higher maternal doses or prolonged use. Because of these concerns, the decision to use Rexipra Plus Tablet while breastfeeding must be individualized. Your doctor may advise using an alternative treatment, adjusting the regimen, closely monitoring the infant for drowsiness and feeding problems, or, in some cases, avoiding breastfeeding.

What precautions should I take while using Rexipra Plus Tablet?Arrow

Inform your doctor about any history of liver or kidney disease, glaucoma, respiratory problems, seizure disorders, bipolar disorder, suicidal thoughts, substance or alcohol misuse, or allergies to benzodiazepines or SSRIs before starting Rexipra Plus Tablet. Avoid driving, operating machinery, or engaging in high-risk tasks until you know how the medicine affects your alertness. Do not combine it with alcohol or other sedative medicines without medical advice. Attend regular follow-up appointments so that your response, side effects, and the ongoing need for clonazepam can be reviewed, and never adjust the dose or stop the medicine on your own.

References

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Escitalopram and Methylcobalamin: A Synergistic Combination in Managing Depression

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DrugBank: Escitalopram

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The role of methylcobalamin in diabetic neuropathy

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FDA Label for Escitalopram

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European Medicines Agency (EMA) assessment report for Escitalopram (Cipralex)

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ScienceDirect: Methylcobalamin

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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