SALBAIR I INHALER

How SALBAIR I INHALER Works

• SALBAIR I INHALER is a combination medication designed to provide relief from bronchospasm (wheezing, shortness of breath) associated with asthma and chronic obstructive pulmonary disease (COPD). It contains two active ingredients: Salbutamol (also known as Albuterol) and Ipratropium.
• Salbutamol is a short-acting beta2-adrenergic receptor agonist. When inhaled, Salbutamol selectively stimulates beta2-adrenergic receptors in the smooth muscle lining the airways of the lungs. This stimulation leads to the activation of an enzyme called adenylyl cyclase, which in turn increases the production of cyclic AMP (cAMP). Increased cAMP levels cause the smooth muscle to relax, resulting in bronchodilation. Bronchodilation widens the airways, making it easier to breathe by allowing more air to flow in and out of the lungs. The effects of salbutamol are typically felt within a few minutes and last for several hours.
• Ipratropium is an anticholinergic bronchodilator. It works by blocking the action of acetylcholine, a neurotransmitter that causes the muscles around the airways to tighten. Acetylcholine normally binds to muscarinic receptors on smooth muscle cells in the bronchi, leading to bronchoconstriction (narrowing of the airways) and increased mucus secretion. Ipratropium blocks these receptors, preventing acetylcholine from binding and thus inhibiting bronchoconstriction. This results in relaxation of the airway muscles and reduced mucus production, further aiding in bronchodilation and easier breathing. The effects of Ipratropium may take a little longer to manifest compared to Salbutamol but provide a more sustained bronchodilation.
• In summary, SALBAIR I INHALER combines the rapid bronchodilating action of Salbutamol with the more sustained bronchodilating effect of Ipratropium. This synergistic combination helps to quickly relieve acute bronchospasm and provides longer-lasting control of airway constriction, making it easier for individuals with asthma or COPD to breathe. It is important to use this inhaler as prescribed by your doctor for optimal management of your respiratory condition.

Like all medicines, Salbair I Inhaler can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Tremor (shaking) * Headache * Increased heart rate (tachycardia) * Palpitations (feeling your heartbeat is faster or irregular) * Cough * Throat irritation * Muscle cramps **Uncommon Side Effects (may affect up to 1 in 100 people):** * Nausea (feeling sick) * Vomiting * Dizziness * Restlessness * Sleeping problems * Unusual taste in the mouth * Urticaria (hives), itching * Sweating **Rare Side Effects (may affect up to 1 in 1,000 people):** * Hypokalaemia (low potassium levels in the blood) * Increased blood sugar levels (hyperglycemia) * Arrhythmia (irregular heartbeat) **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Paradoxical bronchospasm (wheezing or difficulty breathing immediately after using the inhaler). If this happens, stop using Salbair I Inhaler and seek immediate medical help. * Allergic reactions including angioedema (swelling of the face, lips, tongue or throat) * Lactic acidosis (build up of lactic acid in the body) **Other Possible Side Effects:** * Chest pain * Worsening of asthma symptoms **Important:** If you experience any of the following serious side effects, stop using Salbair I Inhaler and seek immediate medical attention: * Sudden wheezing or difficulty breathing * Swelling of the face, lips, tongue or throat * Severe skin rash

• If you miss a dose of Salbair I Inhaler, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to catch up.

• Keep SALBAIR I INHALER away from the reach of children and pets.
• Store SALBAIR I INHALER at room temperature.

• **Prime the Inhaler:** Before using a new Salbair I Inhaler or if it hasn't been used for two weeks, prime it by releasing 4 puffs into the air, away from your face. This ensures the inhaler delivers the correct dose. Shake well before each puff.
• **Correct Inhalation Technique:** Breathe out fully, then place the mouthpiece in your mouth, creating a tight seal with your lips. Start to breathe in slowly and deeply through your mouth while simultaneously pressing down on the canister to release the medication. Continue inhaling deeply. Remove the inhaler from your mouth and hold your breath for about 10 seconds, or as long as comfortable, then breathe out slowly.
• **Clean the Inhaler Regularly:** To prevent blockage and maintain hygiene, clean your Salbair I Inhaler at least once a week. Remove the canister and rinse the plastic actuator with warm water for about 30 seconds. Shake off excess water and allow it to air dry completely before reassembling. Do not wash the canister.
• **Monitor Your Usage:** Salbair I Inhaler is a rescue medication for quick relief of asthma symptoms. If you find yourself using it more frequently than prescribed, it may indicate that your asthma is not well-controlled. Consult your doctor to review your asthma management plan and consider adjustments to your long-term control medications.
• **Carry Your Inhaler at All Times:** Asthma symptoms can occur unexpectedly. Always carry your Salbair I Inhaler with you, so you can promptly relieve symptoms like wheezing, shortness of breath, and chest tightness whenever they arise. Check the expiration date regularly and replace the inhaler before it expires to ensure its effectiveness.

• There are no known interactions between SALBAIR I INHALER and food. It can be used with or without food. However, it's always recommended to follow your doctor's advice regarding the use of this medication.