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Composition
Content Reviewed By:
Dr. Manoj Shah
, (MBBS)
Written By:
Ms. Priyanka Shah
, (B.Pharm)
Most side effects are temporary and subside as your body adapts to SPENZO 0.5MG TABLET 10'S. However, consult your doctor if they persist or cause concern.

Other medical conditions
Use under specialist supervisionSpenzo 0.5 should be used with particular caution in patients with a history of cardiovascular disease, arrhythmias, prolonged QT interval, or those taking other medicines that affect heart rhythm, as antipsychotics can in some cases influence cardiac conduction.
SPENZO 0.5MG TABLET 10'S belongs to a class of medication called as typical antipsychotic. It acts by increasing the amounts of chemical (serotonin), in the brain. SPENZO 0.5MG TABLET 10'S decanoate is a long-acting preparation of SPENZO 0.5MG TABLET 10'S for injection into the muscles, which may be given at a frequency ranging from once in a week to once in 4 weeks
SPENZO 0.5MG TABLET 10'S is used in the treatment of schizophrenia and other psychoses which are disorders where individuals are unable to distinguish between what is real and unreal, think clearly, manage emotions, relate to others, and function normally
SPENZO 0.5MG TABLET 10'S in combination with melitracen is banned in india due to safety concern
SPENZO 0.5MG TABLET 10'S belongs to a class of medication called as typical antipsychotic. It acts by normalizing the levels of certain chemicals in the brain in specific brain pathways that are responsible for causing symptoms of the disease.
Spenzo 0.5 is a prescription medicine that contains flupentixol hydrochloride 0.5 mg, a typical antipsychotic from the thioxanthene class. At this low strength, it is generally used under specialist supervision for certain mood and anxiety-related conditions and, in some settings, as part of treatment for psychotic disorders. The exact approved uses may differ between countries, so patients should follow the advice of their local healthcare provider and the product leaflet.
Spenzo 0.5 is typically prescribed by psychiatrists or physicians for selected patients with depressive or anxiety symptoms, sometimes when these are accompanied by agitation, tension, or other features that may respond to low-dose flupentixol. In some treatment plans it may also be used as part of therapy for psychotic disorders. The indication for an individual patient should be clearly explained by the treating doctor, based on local regulatory approvals and clinical judgement.
Flupentixol primarily blocks dopamine D2 receptors in the brain. By reducing excessive dopaminergic activity in certain pathways, it can help improve symptoms such as agitation, anxiety, and psychotic features like hallucinations or delusions. At low doses, it may have a relatively activating and mood-stabilising effect in some patients, while at higher doses it behaves more as a conventional antipsychotic. The full therapeutic effect may take several days to a few weeks to become evident.
Spenzo 0.5 should be taken exactly as prescribed by your doctor, usually by mouth with water, with or without food. It is important to take it at the same time each day to maintain stable levels in your body. Do not change the dose, frequency, or duration of treatment on your own. If you are unsure about how to take the medicine or what to do if you miss a dose, ask your doctor or pharmacist for personalised instructions. Do not crush or split the tablet unless your doctor or the product leaflet specifically allows this.
Common side effects associated with flupentixol include drowsiness or sedation, dizziness, dry mouth, constipation, increased salivation, blurred vision, restlessness, and weight changes. Some patients may experience movement-related symptoms such as muscle stiffness, tremor, or a feeling of inner restlessness (akathisia). Not everyone will experience these effects, and many are mild and may lessen as treatment continues. If side effects are persistent, troublesome, or worsening, you should discuss them with your doctor.
Yes, although serious reactions are uncommon, they can occur and require urgent medical attention. These include neuroleptic malignant syndrome (characterised by high fever, severe muscle rigidity, confusion, sweating, and unstable blood pressure or heart rate), severe extrapyramidal symptoms or uncontrollable movements, seizures, significant changes in heart rhythm, and severe allergic reactions such as swelling of the face or throat and difficulty breathing. If you develop any of these symptoms, or a sudden marked change in mental state, seek emergency medical care immediately.
Flupentixol is not considered a habit-forming or addictive medicine in the way that benzodiazepines, opioids, or some sedative drugs can be. However, it acts on the central nervous system, and stopping it suddenly after prolonged use may lead to withdrawal-like symptoms such as nausea, sleep disturbance, restlessness, or a return or worsening of the underlying psychiatric condition. For this reason, any change in dose or discontinuation should be done gradually and only under medical supervision.
Alcohol is generally not recommended while taking Spenzo 0.5. Both alcohol and flupentixol act on the central nervous system and can increase drowsiness, dizziness, impaired coordination, and judgement. This combination may raise the risk of falls, accidents, or other adverse effects. Alcohol can also worsen underlying psychiatric symptoms in some individuals. If you consume alcohol, discuss this with your doctor so that you can receive personalised advice and monitoring.
If you miss a dose, follow the instructions provided by your doctor or pharmacist. In general, if it is only a short time after the scheduled dose, you may be advised to take it as soon as you remember. If it is almost time for your next dose, you may be told to skip the missed dose and resume your usual schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently forget doses, inform your doctor so that strategies can be discussed.
You should not stop Spenzo 0.5 on your own, even if you feel better. Psychiatric symptoms can recur if treatment is stopped too early or abruptly. Your doctor will decide how long you need to continue therapy based on your diagnosis, response, and risk of relapse. When it is appropriate to stop, the dose is usually reduced gradually to minimise withdrawal-like symptoms and to monitor for any return of the underlying condition. Always follow your doctor’s instructions regarding treatment duration.
Yes, Spenzo 0.5 can interact with several other medicines. Interactions may occur with other antipsychotics, antidepressants, sedatives, opioid painkillers, antihistamines that cause drowsiness, medicines that affect heart rhythm (such as some antiarrhythmics and certain antibiotics), and drugs that lower blood pressure. Some medicines that influence liver enzymes may also affect flupentixol levels. Always inform your doctor and pharmacist about all prescription medicines, over-the-counter products, and herbal supplements you are taking before starting Spenzo 0.5.
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