SYMBICORT 160/4.5 TURBUHALER

How SYMBICORT 160/4.5 TURBUHALER Works

• SYMBICORT 160/4.5 Turbuhaler is a combination inhaler containing two active ingredients: budesonide and formoterol. These components work synergistically to manage asthma and chronic obstructive pulmonary disease (COPD). Budesonide is an inhaled corticosteroid that reduces inflammation in the airways. Formoterol is a long-acting beta2-agonist (LABA) that relaxes the muscles around the airways, improving airflow.
• Budesonide's mechanism of action involves binding to glucocorticoid receptors in the airway cells. This interaction inhibits the release of inflammatory mediators, such as cytokines and chemokines, which are responsible for the swelling and mucus production characteristic of asthma and COPD. By reducing inflammation, budesonide helps to prevent asthma attacks and COPD exacerbations, leading to improved lung function over time.
• Formoterol, on the other hand, works by stimulating beta2-adrenergic receptors on the smooth muscle cells surrounding the airways. This stimulation causes the muscles to relax, resulting in bronchodilation, or the widening of the airways. The bronchodilatory effect of formoterol provides rapid relief from symptoms such as wheezing, shortness of breath, and chest tightness. Its long-acting nature ensures that the airways remain open for an extended period, providing sustained symptom control.
• The combination of budesonide and formoterol in SYMBICORT 160/4.5 Turbuhaler addresses both the inflammatory and bronchoconstriction aspects of asthma and COPD. Budesonide tackles the underlying inflammation that contributes to airway hyperreactivity, while formoterol provides quick and lasting bronchodilation to alleviate symptoms. This dual action helps to improve overall lung function, reduce the frequency of exacerbations, and enhance the quality of life for individuals with these respiratory conditions.
• The Turbuhaler device itself is a dry powder inhaler that delivers a consistent dose of medication with each inhalation. The patient inhales the medication directly into the lungs, where it can exert its therapeutic effects. Proper inhalation technique is essential to ensure that the medication reaches the airways effectively. Patients should be instructed on the correct use of the Turbuhaler device by a healthcare professional.

Like all medicines, SYMBICORT 160/4.5 TURBUHALER can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Palpitations (feeling your heartbeat), tremor or shaking. If these effects occur, they are normally mild and usually disappear as you continue to use SYMBICORT 160/4.5 TURBUHALER. * Thrush (a fungal infection) in the mouth; this is less likely if you rinse your mouth out with water after using your inhaler. * Mild sore throat, coughing and a hoarse voice. * Headache. **Uncommon side effects (may affect up to 1 in 100 people):** * Feeling restless, nervous or agitated. * Disturbed sleep. * Feeling dizzy. * Blurred vision. * Nausea (feeling sick). * Fast heartbeat. * Bruising. * Muscle cramps. **Rare side effects (may affect up to 1 in 1,000 people):** * Rash, itching. * Bronchospasm (tightening of the muscles in the airways, which causes wheezing). If this happens, stop using SYMBICORT 160/4.5 TURBUHALER immediately and talk to your doctor. * Angioedema: Signs may include swelling of the face, lips, tongue, and/or throat, possibly causing difficulty breathing or swallowing. * Low potassium levels in your blood. * Uneven heart beat. **Very rare side effects (may affect up to 1 in 10,000 people):** * Depression. * Changes in behaviour. * Chest pain or a feeling of chest tightness (angina). * An increase in the amount of sugar (glucose) in your blood. * Taste changes, such as an unpleasant taste in the mouth. * Changes in your blood pressure. **Other Possible Side Effects:** * Worsening of your asthma or breathing difficulties. * Systemic effects: Systemic effects may occur with inhaled corticosteroids, particularly at high doses prescribed for prolonged periods. These effects are much less likely to occur than with oral corticosteroids. Possible systemic effects include: adrenal suppression (effects on adrenal gland function), reduction in bone mineral density, cataract and glaucoma (increased pressure in the eye).

• If you miss a dose of SYMBICORT 160/4.5 TURBUHALER, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not double the dose to catch up.

• Keep SYMBICORT 160/4.5MCG TURBUHALER away from the reach of children and pets.
• Store SYMBICORT 160/4.5MCG TURBUHALER in a refrigerator (2 - 8°C). Do not freeze.

• **Understand Your Medication:** Symbicort 160/4.5 Turbuhaler is a combination inhaler containing budesonide (a corticosteroid) and formoterol (a long-acting beta-agonist). Budesonide reduces inflammation in the lungs, while formoterol helps to open airways. It's crucial to understand how each component works to manage your asthma or COPD effectively.
• **Proper Inhalation Technique is Key:** Ensure you are using the correct inhalation technique. Exhale fully before placing the mouthpiece in your mouth. Inhale deeply and forcefully through the Turbuhaler, hold your breath for about 10 seconds, and then exhale slowly. If you are unsure about your technique, ask your doctor or pharmacist for a demonstration.
• **Regular Use is Essential:** For optimal results, use Symbicort 160/4.5 Turbuhaler as prescribed by your doctor, even if you feel well. Consistent use helps to control inflammation and prevent symptoms from worsening. Do not stop using it without consulting your doctor, as this may lead to a flare-up of your condition.
• **Rinse Your Mouth After Each Use:** After each inhalation, rinse your mouth with water and spit it out. This helps to prevent oral thrush (a fungal infection in the mouth) and reduce the risk of hoarseness. Do not swallow the water.
• **Monitor for Side Effects and Interactions:** Be aware of potential side effects, such as sore throat, headache, or tremor. If you experience any persistent or severe side effects, consult your doctor. Also, inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements, to avoid potential drug interactions.
• **Keep Track of Doses:** Keep track of how many doses you have used. The Turbuhaler has a dose indicator that shows approximately how many doses are left. When the red mark appears in the indicator window, it means there are about 20 doses left. Get a refill before you run out of medication.
• **Cleaning and Maintenance:** The Turbuhaler device should be kept clean and dry. Do not wash or immerse the inhaler in water. Wipe the mouthpiece regularly with a dry cloth.
• **Storage Instructions:** Store your Symbicort Turbuhaler at room temperature, away from direct sunlight and moisture. Keep it out of reach of children.
• **Asthma Action Plan:** If you have asthma, work with your doctor to develop an asthma action plan. This plan should outline how to manage your asthma, including when to use your Symbicort Turbuhaler, when to increase the dose, and when to seek medical attention.
• **Carry Your Rescue Inhaler:** Always carry your rescue inhaler (such as albuterol) with you for quick relief of sudden asthma symptoms. Symbicort is not a rescue inhaler and should not be used to treat sudden breathing problems.