SYNCAPONE 150MG TABLET 10'S
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SYNCAPONE 150MG TABLET 10'SSYNCAPONE 150MG TABLET 10'SSYNCAPONE 150MG TABLET 10'S
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SYNCAPONE 150MG TABLET 10'S

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SYNCAPONE 150MG TABLET 10'S

By SUN PHARMACEUTICAL INDUSTRIES LTD

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148

₹125.8

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About SYNCAPONE 150MG TABLET 10'S

  • SYNCAPONE 150MG TABLET 10'S is a medication primarily used in the management of Parkinson's disease. It is a combination medicine containing carbidopa, levodopa, and entacapone. Levodopa is a precursor to dopamine, a neurotransmitter deficient in Parkinson's disease. Carbidopa inhibits the breakdown of levodopa in the body, allowing more of it to reach the brain. Entacapone further enhances the effect of levodopa by blocking an enzyme that breaks down dopamine.
  • This combination helps to increase dopamine levels in the brain, thereby reducing the symptoms of Parkinson's disease such as tremors, stiffness, slow movement, and balance problems. SYNCAPONE 150MG is designed to provide a more consistent and sustained relief from these symptoms compared to levodopa alone.
  • The recommended dosage and duration of treatment with SYNCAPONE 150MG TABLET 10'S are determined by a physician based on individual patient needs and response to the medication. It's crucial to follow the doctor's instructions carefully. Patients should also be aware of potential side effects, which may include nausea, dyskinesia (uncontrolled movements), dizziness, and changes in mental state. Regular monitoring by a healthcare professional is important during treatment.
  • SYNCAPONE offers a multifaceted approach to managing Parkinson's, addressing dopamine deficiency through levodopa while carbidopa and entacapone optimize its effectiveness. This three-pronged strategy aims to provide enhanced symptom control and improved quality of life for individuals living with Parkinson's disease.

Uses of SYNCAPONE 150MG TABLET 10'S

  • Treatment of Parkinson's disease
  • Relief from symptoms of Parkinson's disease
  • Reducing body stiffness
  • Reducing tremors
  • Improving muscle control
  • Reducing difficulty in walking
  • Addressing slow movement issues

How SYNCAPONE 150MG TABLET 10'S Works

  • SYNCAPONE 150MG TABLET 10'S is a combination medication meticulously formulated to manage the symptoms of Parkinson's disease. It contains three active ingredients: Levodopa, Carbidopa, and Entacapone, each playing a vital role in alleviating the debilitating effects of this neurodegenerative disorder.
  • Levodopa is a precursor to dopamine, a neurotransmitter crucial for controlling movement. In Parkinson's disease, the brain's ability to produce dopamine is significantly impaired, leading to motor symptoms like tremors, rigidity, slowness of movement (bradykinesia), and postural instability. Levodopa crosses the blood-brain barrier and is converted into dopamine within the brain, effectively replenishing the depleted dopamine levels and improving motor function.
  • However, when Levodopa is administered alone, a significant portion of it is broken down in the bloodstream and peripheral tissues before it can reach the brain. This is where Carbidopa comes in. Carbidopa is a dopa decarboxylase inhibitor. It inhibits the enzyme dopa decarboxylase, which is responsible for breaking down Levodopa outside the brain. By blocking this enzyme, Carbidopa allows more Levodopa to reach the brain, increasing its effectiveness and reducing the required dose. This, in turn, helps minimize some of the side effects associated with Levodopa.
  • Entacapone is a catechol-O-methyltransferase (COMT) inhibitor. COMT is another enzyme that breaks down Levodopa in the bloodstream. Entacapone works by inhibiting this enzyme, further preventing the breakdown of Levodopa and prolonging its therapeutic effect. By inhibiting both dopa decarboxylase and COMT, SYNCAPONE ensures that a greater and more sustained amount of Levodopa is available in the brain to alleviate Parkinson's symptoms.
  • In essence, SYNCAPONE 150MG TABLET 10'S employs a three-pronged approach to maximize the benefits of Levodopa therapy. Carbidopa protects Levodopa from premature breakdown in the periphery, and Entacapone extends its duration of action. This synergistic combination helps to improve motor control, reduce the severity of Parkinson's symptoms, and enhance the overall quality of life for individuals living with this challenging condition. The precise dosage and administration schedule are determined by a healthcare professional based on individual patient needs and response to treatment. Regular monitoring is crucial to adjust the dosage and manage any potential side effects.

Side Effects of SYNCAPONE 150MG TABLET 10'SArrow

Common side effects of SYNCAPONE 150MG TABLET may include: nausea, vomiting, diarrhea, constipation, dry mouth, dizziness, lightheadedness, drowsiness, headache, confusion, hallucinations, abnormal dreams, insomnia, dyskinesia (uncontrolled movements), muscle cramps, increased sweating, blurred vision, changes in blood pressure, and urine discoloration. Less common but potentially serious side effects include: severe depression, suicidal thoughts, psychosis, impulse control disorders (such as compulsive gambling or hypersexuality), neuroleptic malignant syndrome (NMS), rhabdomyolysis, and liver problems. Allergic reactions such as rash, itching, or swelling are also possible. Contact your doctor immediately if you experience any serious or persistent side effects.

Safety Advice for SYNCAPONE 150MG TABLET 10'SArrow

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Allergies

Allergies

Consult your Doctor.

Dosage of SYNCAPONE 150MG TABLET 10'SArrow

  • The recommended dosage of SYNCAPONE 150MG TABLET 10'S varies significantly depending on the individual patient's needs and response to treatment. It's crucial to understand that SYNCAPONE is used to manage the symptoms of Parkinson's disease, and the optimal dose is determined by carefully balancing symptom control with the potential for side effects. The dosage is not fixed and requires careful titration by a healthcare professional.
  • Initially, your doctor will likely start you on a low dose and gradually increase it until the desired therapeutic effect is achieved. This titration process can take several weeks or even months. The goal is to find the lowest dose that effectively manages your symptoms without causing intolerable side effects such as dyskinesias (involuntary movements), nausea, or orthostatic hypotension (a drop in blood pressure upon standing).
  • The frequency of administration also varies; some patients may take SYNCAPONE multiple times a day, while others may find that a less frequent schedule is sufficient. Adherence to your doctor's specific instructions is paramount. Do not alter the dose or frequency of administration without consulting your physician. Sudden changes in dosage can lead to a worsening of symptoms or the development of adverse effects.
  • Factors influencing the dosage include the severity of your Parkinson's disease, your response to levodopa, and any other medications you may be taking. Your doctor will also consider your overall health and any other medical conditions you have. Regular monitoring and follow-up appointments are essential to ensure that the dosage remains appropriate and effective over time.
  • It is also important to be aware of the potential for the 'wearing-off' effect, where the benefits of each dose may diminish before the next dose is due. If you experience this, discuss it with your doctor, as they may need to adjust your dosage or add another medication to your regimen. Take 'SYNCAPONE 150MG TABLET 10'S' only as per the prescription by your physician only.

What if I miss my dose of SYNCAPONE 150MG TABLET 10'S?Arrow

  • If you miss a dose of SYNCAPONE 150MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How to store SYNCAPONE 150MG TABLET 10'S?Arrow

  • Keep SYNCAPONE 150MG TAB 1X10 away from the reach of children and pets.
  • Store SYNCAPONE 150MG TAB 1X10 at room temperature.

Benefits of SYNCAPONE 150MG TABLET 10'SArrow

  • SYNCAPONE 150MG TABLET 10'S is a combination medicine primarily used to manage the symptoms of Parkinson's disease. Parkinson's disease is a progressive disorder that affects the nervous system, leading to tremors, stiffness, slowness of movement, and postural instability. SYNCAPONE contains levodopa, carbidopa, and entacapone, each playing a crucial role in alleviating these symptoms.
  • Levodopa is a precursor to dopamine, a neurotransmitter that is deficient in individuals with Parkinson's disease. By converting into dopamine in the brain, levodopa helps to replenish dopamine levels, thereby reducing motor symptoms like tremors and rigidity. This leads to improved mobility and coordination, enabling patients to perform daily activities with greater ease.
  • Carbidopa works by inhibiting the breakdown of levodopa in the bloodstream, allowing more levodopa to reach the brain. This not only increases the amount of levodopa available to be converted into dopamine but also helps to reduce the side effects associated with levodopa, such as nausea and vomiting. By enhancing levodopa's effectiveness, carbidopa contributes to a more stable and consistent therapeutic response.
  • Entacapone further enhances the effects of levodopa by preventing the breakdown of dopamine in the brain. It inhibits an enzyme called COMT (catechol-O-methyltransferase), which is responsible for metabolizing dopamine. By blocking COMT, entacapone prolongs the duration of action of levodopa, providing longer-lasting relief from Parkinson's symptoms. This helps to reduce 'off' periods, where symptoms return between doses of levodopa.
  • The combined action of levodopa, carbidopa, and entacapone in SYNCAPONE 150MG TABLET 10'S provides a comprehensive approach to managing Parkinson's disease symptoms. It effectively reduces tremors, muscle stiffness, and slowness of movement, significantly improving motor control and overall quality of life. Patients often experience enhanced ability to perform everyday tasks, such as walking, dressing, and eating, leading to increased independence and well-being.
  • Furthermore, SYNCAPONE's formulation helps in maintaining more stable dopamine levels in the brain, reducing fluctuations in motor control throughout the day. This can lead to a more predictable and consistent response to treatment, minimizing the impact of Parkinson's symptoms on daily life. Regular use, as prescribed by a healthcare professional, can help individuals with Parkinson's disease lead more active and fulfilling lives.
  • It is important to note that while SYNCAPONE helps manage the symptoms of Parkinson's, it does not cure the disease. Consistent monitoring and adjustments to the dosage may be necessary to optimize treatment outcomes. Patients should work closely with their healthcare provider to manage their condition effectively.

How to use SYNCAPONE 150MG TABLET 10'SArrow

  • SYNCAPONE 150MG TABLET is a medication primarily used in the management of Parkinson's disease. It's crucial to adhere to your doctor's prescribed dosage and schedule for optimal results. Typically, SYNCAPONE is taken orally, and it can be taken with or without food. However, consistency in how you take it (always with food or always without) can help maintain consistent drug levels in your body.
  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this can affect how the medication is absorbed. If you have difficulty swallowing pills, discuss this with your doctor or pharmacist; they may be able to suggest alternative formulations or strategies.
  • The dosage of SYNCAPONE is highly individualized and depends on your specific condition, response to treatment, and other medications you may be taking. Your doctor will likely start you on a low dose and gradually increase it until the desired effect is achieved. It's imperative that you do not adjust your dosage on your own without consulting your healthcare provider.
  • It's vital to take SYNCAPONE at regular intervals, as prescribed by your doctor. Missing doses can lead to a return of Parkinson's symptoms. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one.
  • During treatment with SYNCAPONE, be mindful of potential side effects. Common side effects may include nausea, dizziness, drowsiness, and involuntary movements (dyskinesias). If these side effects are bothersome or persistent, inform your doctor. They may adjust your dosage or recommend ways to manage the side effects.
  • Avoid taking iron supplements or medications containing iron within a few hours of taking SYNCAPONE, as iron can interfere with the absorption of the medication. Also, inform your doctor about all other medications, supplements, and herbal products you are taking, as they may interact with SYNCAPONE.
  • It's crucial to maintain regular follow-up appointments with your doctor to monitor your progress and adjust your treatment plan as needed. Do not stop taking SYNCAPONE suddenly, as this can lead to withdrawal symptoms. If you need to discontinue the medication, your doctor will gradually reduce the dosage to minimize the risk of withdrawal effects.
  • Store SYNCAPONE tablets at room temperature, away from heat, light, and moisture. Keep the medication out of reach of children and pets. If you have any questions or concerns about using SYNCAPONE, consult your doctor or pharmacist for personalized guidance.

Quick Tips for SYNCAPONE 150MG TABLET 10'SArrow

  • Take SYNCAPONE 150MG TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting your healthcare provider. This ensures the medication works effectively and minimizes potential side effects. It is important to adhere to the prescribed regimen for optimal results in managing your symptoms.
  • SYNCAPONE 150MG TABLET 10'S is typically taken with food to enhance absorption and reduce the risk of nausea. Consuming it on an empty stomach may lead to gastrointestinal discomfort. If you experience persistent nausea, discuss this with your doctor. Consistent administration with meals can improve tolerability and effectiveness.
  • Maintain a consistent dosing schedule for SYNCAPONE 150MG TABLET 10'S. Taking the medication at the same times each day helps maintain a stable level of the drug in your system, which is crucial for managing symptoms effectively. Utilize reminders, such as alarms or medication organizers, to aid adherence.
  • Inform your doctor about all other medications, supplements, and herbal products you are currently taking before starting SYNCAPONE 150MG TABLET 10'S. Drug interactions can alter the effectiveness of SYNCAPONE 150MG TABLET 10'S or increase the risk of side effects. This includes over-the-counter medications and herbal remedies. A comprehensive medication review is essential for your safety.
  • Be aware that SYNCAPONE 150MG TABLET 10'S may cause side effects such as dyskinesia (involuntary movements), nausea, dizziness, or hallucinations. If you experience any concerning side effects, contact your doctor immediately. Do not discontinue the medication abruptly without medical advice, as this can lead to withdrawal symptoms or a worsening of your condition.

Food Interactions with SYNCAPONE 150MG TABLET 10'SArrow

  • SYNCAPONE 150MG TABLET 10'S should be taken as prescribed by your doctor. It is recommended to take this medicine on an empty stomach, at least 30 minutes before or 60 minutes after meals. High-protein foods may interfere with the absorption of the drug, reducing its effectiveness. Therefore, it's advisable to maintain a consistent dietary pattern and avoid excessive protein intake around the time you take SYNCAPONE.

FAQs

What is SYNCAPONE 150MG TABLET 10'S and what is it used for?Arrow

SYNCAPONE 150MG TABLET 10'S is a combination medicine containing levodopa, carbidopa, and entacapone. It is used to manage symptoms of Parkinson's disease like tremors, stiffness, and slow movement.

How does SYNCAPONE 150MG TABLET 10'S work?Arrow

SYNCAPONE 150MG TABLET 10'S works by increasing dopamine levels in the brain. Levodopa converts into dopamine, carbidopa prevents the breakdown of levodopa, and entacapone enhances the effect of dopamine.

What are the common side effects of SYNCAPONE 150MG TABLET 10'S?Arrow

Common side effects of SYNCAPONE 150MG TABLET 10'S include nausea, vomiting, involuntary movements, dizziness, and constipation.

How should I take SYNCAPONE 150MG TABLET 10'S?Arrow

Take SYNCAPONE 150MG TABLET 10'S exactly as prescribed by your doctor. It can be taken with or without food. Do not change the dosage or stop the medicine abruptly.

What precautions should I take while taking SYNCAPONE 150MG TABLET 10'S?Arrow

While taking SYNCAPONE 150MG TABLET 10'S, you may experience dizziness, fainting, or changes in blood pressure. Limit alcohol consumption and rise slowly from sitting or lying down. Inform your doctor if you are pregnant or breastfeeding.

Can SYNCAPONE 150MG TABLET 10'S interact with other medications?Arrow

SYNCAPONE 150MG TABLET 10'S can interact with certain medications such as MAO inhibitors, iron supplements, and some antidepressants. Inform your doctor about all the medications you are taking.

How should I store SYNCAPONE 150MG TABLET 10'S?Arrow

Store SYNCAPONE 150MG TABLET 10'S at room temperature, away from heat and moisture. Keep it out of reach of children and pets.

What are the symptoms of an overdose of SYNCAPONE 150MG TABLET 10'S?Arrow

Symptoms of an overdose of SYNCAPONE 150MG TABLET 10'S may include confusion, hallucinations, fast or irregular heartbeat, and uncontrolled movements.

What should I do if I miss a dose of SYNCAPONE 150MG TABLET 10'S?Arrow

If you miss a dose of SYNCAPONE 150MG TABLET 10'S, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Can SYNCAPONE 150MG TABLET 10'S cure Parkinson's disease?Arrow

No, SYNCAPONE 150MG TABLET 10'S cannot cure Parkinson's disease, but it can help manage the symptoms.

What are the alternatives to Syncapone?Arrow

Alternatives to Syncapone include individual combination medications containing levodopa, carbidopa and entacapone, or other medications as prescribed by your doctor.

Is it safe to drive while taking SYNCAPONE 150MG TABLET 10'S?Arrow

SYNCAPONE 150MG TABLET 10'S can cause dizziness or drowsiness, so use caution when driving or operating machinery.

Can I take iron supplements with SYNCAPONE 150MG TABLET 10'S?Arrow

Iron supplements can reduce the absorption of SYNCAPONE 150MG TABLET 10'S. If you need to take iron supplements, take them at a different time than SYNCAPONE.

How long does it take to feel the effects of SYNCAPONE 150MG TABLET 10'S?Arrow

It may take a few days or weeks to feel the effects of SYNCAPONE 150MG TABLET 10'S.

Can stress affect SYNCAPONE 150MG TABLET 10'S?Arrow

Stress can exacerbate symptoms of Parkinson's disease, which in turn may affect the effectiveness of SYNCAPONE 150MG TABLET 10'S. It is important to manage stress.

References

Book Icon

SYNCOPA® (carbidopa, levodopa and entacapone) Tablets, for oral use. Full Prescribing Information. NDA 21-484. Approved by FDA, 2003.

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DrugBank: Levodopa. A detailed drug data including mechanism of action, indication, pharmacology, and interactions.

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DrugBank: Carbidopa. A detailed drug data including mechanism of action, indication, pharmacology, and interactions.

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DrugBank: Entacapone. A detailed drug data including mechanism of action, indication, pharmacology, and interactions.

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National Center for Biotechnology Information (NCBI): Entacapone-Induced Cholestatic Liver Injury: A Case Report and Review of the Literature

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European Medicines Agency (EMA): Stalevo. Summary of Product Characteristics.

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National Center for Biotechnology Information (NCBI): Carbidopa/Levodopa. Provides a review of carbidopa/levodopa, including its mechanism of action, adverse effects, and clinical use.

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Marketer / Manufacturer Details

SUN PHARMACEUTICAL INDUSTRIES LTD

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India

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