TAZACT 1.125GM INJECTION
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TAZACT 1.125GM INJECTION
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TAZACT 1.125GM INJECTION

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TAZACT 1.125GM INJECTION

By CIPLA PHARMACEUTICAL COMPANY LIMITED

MRP

111.6

₹106.02

5 % OFF

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Product DetailsArrow

About TAZACT 1.125GM INJECTION

  • TAZACT 1.125GM INJECTION is a powerful antibiotic combination containing two active ingredients: Piperacillin and Tazobactam. This injectable medication is primarily used to treat a wide range of bacterial infections, especially those that are resistant to other antibiotics. Piperacillin belongs to the penicillin class of antibiotics and works by interfering with the bacteria's ability to form cell walls, leading to their destruction. Tazobactam is a beta-lactamase inhibitor, which means it prevents bacteria from inactivating Piperacillin, thereby enhancing its effectiveness.
  • This combination is particularly effective against infections of the lower respiratory tract (pneumonia), urinary tract, skin and soft tissues, and intra-abdominal infections. It's often used in hospital settings for treating severe infections, including sepsis. TAZACT 1.125GM INJECTION should only be administered by a healthcare professional and its dosage and duration are determined based on the severity and location of the infection, as well as the patient's overall health.
  • Before receiving TAZACT 1.125GM INJECTION, inform your doctor about any allergies you have, especially to penicillin or other beta-lactam antibiotics. Also, disclose any existing medical conditions, such as kidney problems or bleeding disorders. Common side effects may include nausea, diarrhea, and injection site reactions. While generally safe, it's crucial to use this medication responsibly to prevent the development of antibiotic resistance. Always complete the full course of treatment as prescribed, even if you start feeling better before the prescribed duration.

Uses of TAZACT 1.125GM INJECTION

  • Treatment of Pneumonia
  • Treatment of Skin and Soft Tissue Infections
  • Treatment of Intra-abdominal Infections
  • Treatment of Gynecological Infections
  • Treatment of Septicemia
  • Prevention of Surgical Site Infections
  • Treatment of Urinary Tract Infections
  • Treatment of Bone and Joint Infections
  • Treatment of Pneumonia (Hospital-Acquired)
  • Treatment of Lung Infections

How TAZACT 1.125GM INJECTION Works

  • TAZACT 1.125GM INJECTION is a powerful antibiotic combination medication containing two active ingredients: Piperacillin and Tazobactam. These components work synergistically to combat a wide spectrum of bacterial infections. Piperacillin belongs to the penicillin group of antibiotics and functions by interfering with the bacteria's ability to build their cell walls. Specifically, it inhibits the synthesis of peptidoglycans, which are essential structural components of bacterial cell walls. Without properly formed cell walls, bacteria become weak, unstable, and eventually lyse (burst), leading to their death and clearing the infection.
  • However, some bacteria have developed resistance mechanisms against penicillin-based antibiotics like Piperacillin. One common mechanism is the production of enzymes called beta-lactamases. These enzymes can break down the beta-lactam ring, a crucial structural element in penicillin antibiotics, rendering them ineffective. This is where Tazobactam plays a crucial role. Tazobactam is a beta-lactamase inhibitor. It binds to beta-lactamase enzymes, preventing them from inactivating Piperacillin. By neutralizing the beta-lactamase enzymes, Tazobactam ensures that Piperacillin can reach its target – the bacterial cell wall – and effectively inhibit its synthesis.
  • In essence, TAZACT 1.125GM INJECTION works by a two-pronged approach: Piperacillin directly attacks the bacterial cell wall, while Tazobactam protects Piperacillin from being destroyed by bacterial resistance mechanisms. This combination allows for a broader spectrum of activity against various bacteria, including those that may be resistant to Piperacillin alone. This synergistic action makes TAZACT 1.125GM INJECTION a valuable tool in treating serious bacterial infections, helping patients recover faster and more effectively.
  • The effectiveness of TAZACT 1.125GM INJECTION relies on maintaining adequate concentrations of both Piperacillin and Tazobactam at the site of infection. This is achieved through intravenous administration, which allows the medication to be rapidly distributed throughout the body. The dosage and frequency of administration are determined by a healthcare professional based on the severity and location of the infection, as well as the patient's overall health status. Therefore, it's essential to follow the doctor's instructions precisely to ensure optimal therapeutic outcomes and minimize the risk of antibiotic resistance.

Side Effects of TAZACT 1.125GM INJECTIONArrow

Like all medicines, TAZACT 1.125GM INJECTION can cause side effects, although not everybody gets them. **Common Side Effects (May affect up to 1 in 10 people):** * Diarrhea * Nausea * Vomiting * Skin rash * Itching * Injection site reactions (pain, redness, swelling) * Elevated liver enzymes **Uncommon Side Effects (May affect up to 1 in 100 people):** * Headache * Dizziness * Fungal infections (e.g., oral thrush) * Abdominal pain * Indigestion * Inflammation of the vein (phlebitis) * Muscle pain * Joint pain * Decreased white blood cell count (leukopenia, neutropenia) * Decreased platelet count (thrombocytopenia) * Elevated creatinine levels * Allergic reactions, including hives **Rare Side Effects (May affect up to 1 in 1,000 people):** * Severe allergic reactions (anaphylaxis) * Seizures * Inflammation of the colon (pseudomembranous colitis) * Liver problems (e.g., hepatitis) * Kidney problems * Stevens-Johnson syndrome (severe skin reaction) * Toxic epidermal necrolysis (severe skin reaction) **Very Rare Side Effects (May affect up to 1 in 10,000 people):** * Drug-induced aseptic meningitis **Frequency Not Known (Frequency cannot be estimated from the available data):** * Clostridium difficile-associated diarrhea * Agranulocytosis (severe deficiency of white blood cells) * Hemolytic anemia (destruction of red blood cells) **Important Note:** This is not a complete list of all possible side effects. If you experience any unusual symptoms while taking TAZACT 1.125GM INJECTION, consult your doctor immediately.

Safety Advice for TAZACT 1.125GM INJECTIONArrow

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Allergies

Allergies

Do not use TAZACT 1.125GM INJECTION if you are allergic to it.

Dosage of TAZACT 1.125GM INJECTIONArrow

  • The recommended dosage of TAZACT 1.125GM INJECTION varies depending on the severity and type of infection, the patient's renal function, and overall clinical condition. It's crucial to adhere strictly to your healthcare provider's prescribed dosage regimen. For adults with normal renal function, a common dosage is 3.375 grams (3 grams of piperacillin and 0.375 grams of tazobactam) administered intravenously every six hours. In cases of more severe infections, the dosage may be increased to 4.5 grams (4 grams of piperacillin and 0.5 grams of tazobactam) every six hours.
  • For patients with impaired renal function, dosage adjustments are necessary to prevent drug accumulation and potential toxicity. Your doctor will carefully assess your kidney function (creatinine clearance) and adjust the TAZACT dosage accordingly. It is very important to inform your doctor about your kidney health.
  • The duration of treatment with TAZACT 1.125GM INJECTION also depends on the type and severity of the infection. Treatment typically lasts for 7-10 days, but it can be longer for more severe or complicated infections. It is essential to complete the full course of treatment as prescribed by your doctor, even if you start feeling better, to ensure that the infection is completely eradicated and to prevent the development of antibiotic resistance. Do not skip any doses.
  • TAZACT 1.125GM INJECTION is administered intravenously, usually over a period of 30 minutes. The injection should be prepared and administered by a healthcare professional. It's important to monitor patients for any signs of adverse reactions during and after the infusion.
  • Take 'TAZACT 1.125GM INJECTION' only as per the prescription by your physician only

What if I miss my dose of TAZACT 1.125GM INJECTION?Arrow

  • As TAZACT 1.125GM INJECTION is administered by a healthcare professional, the chances of missing a dose are unlikely. However, if you believe you may have missed a dose, inform your doctor or healthcare provider immediately.

How to store TAZACT 1.125GM INJECTION?Arrow

  • Keep TAZACT 1.125GM INJ away from the reach of children and pets.
  • Store TAZACT 1.125GM INJ at room temperature.

Benefits of TAZACT 1.125GM INJECTIONArrow

  • TAZACT 1.125GM INJECTION is a powerful antibiotic medication combining two active ingredients: piperacillin and tazobactam. This combination broadens the spectrum of antibacterial activity, making it effective against a wide range of bacterial infections. Piperacillin is a penicillin-derivative antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial cell death. Tazobactam is a beta-lactamase inhibitor, which prevents bacteria from inactivating piperacillin, thereby enhancing its effectiveness.
  • One of the primary benefits of TAZACT 1.125GM INJECTION is its ability to treat severe bacterial infections, including pneumonia, bloodstream infections (bacteremia), skin and soft tissue infections, intra-abdominal infections, and gynecological infections. It is often used in hospital settings for patients who require intensive care and immediate treatment.
  • TAZACT INJECTION is particularly useful in treating infections caused by bacteria that are resistant to other antibiotics. Beta-lactamase enzymes produced by certain bacteria can break down penicillin-based antibiotics, rendering them ineffective. Tazobactam inhibits these enzymes, allowing piperacillin to effectively target and eliminate the bacteria.
  • The broad-spectrum activity of TAZACT 1.125GM INJECTION makes it a valuable option for empiric therapy, where the specific causative bacteria is not yet identified. In such cases, it can provide coverage against a wide range of potential pathogens, increasing the likelihood of a positive clinical outcome while awaiting culture and sensitivity results.
  • Another key benefit is its effectiveness against both gram-positive and gram-negative bacteria, as well as anaerobic bacteria. This comprehensive coverage is crucial in mixed infections where multiple types of bacteria are present.
  • TAZACT 1.125GM INJECTION offers a reliable and effective treatment option for patients with compromised immune systems who are more susceptible to severe infections. Its potent antibacterial activity helps to control and eliminate infections quickly, reducing the risk of complications and improving patient outcomes.
  • The injectable form of TAZACT ensures rapid absorption and distribution of the medication throughout the body, allowing for prompt therapeutic effects. This is particularly important in severe infections where a quick response is critical.
  • TAZACT 1.125GM INJECTION can also be used prophylactically in certain surgical procedures to prevent post-operative infections. By administering the medication before or during surgery, the risk of bacterial contamination and subsequent infection can be significantly reduced.
  • Moreover, the combination of piperacillin and tazobactam in TAZACT INJECTION often allows for lower doses of piperacillin to be used while maintaining efficacy, potentially reducing the risk of side effects associated with higher doses of single-agent antibiotics. This synergistic effect enhances the overall safety profile of the medication.
  • TAZACT is frequently used in the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis, where infection has spread to the kidneys. Its broad-spectrum activity and ability to achieve high concentrations in the urinary tract make it a valuable option in these cases.
  • Additionally, TAZACT can be beneficial in treating infections in patients with underlying conditions such as diabetes, chronic lung disease, or cystic fibrosis, who are at higher risk for developing severe and antibiotic-resistant infections.
  • The efficacy of TAZACT 1.125GM INJECTION is supported by extensive clinical data and research, demonstrating its effectiveness in treating a variety of bacterial infections. This evidence-based approach provides confidence in its use as a first-line treatment option in many clinical scenarios.

How to use TAZACT 1.125GM INJECTIONArrow

  • TAZACT 1.125GM INJECTION is typically administered intravenously by a healthcare professional in a hospital or clinical setting. It is crucial to follow the doctor's instructions regarding dosage and administration schedule. The dosage of TAZACT 1.125GM INJECTION depends on several factors, including the severity and type of infection, the patient's kidney function, and overall health condition. The usual duration of treatment ranges from 7 to 10 days, but can be extended based on the infection's response.
  • Before administration, the injection needs to be reconstituted with a compatible intravenous fluid as per the manufacturer's guidelines. The reconstituted solution should be visually inspected for particulate matter and discoloration before use. It is usually infused slowly over 30 minutes to avoid rapid administration-related side effects. Proper hand hygiene must be ensured before handling the injection. The IV site must be observed for any signs of inflammation or infection.
  • During treatment, it is essential to maintain adequate hydration. Inform your healthcare provider immediately if you experience any adverse reactions such as skin rash, itching, swelling, difficulty breathing, or diarrhea. It is important to complete the full course of TAZACT 1.125GM INJECTION, even if you start feeling better, to eradicate the infection completely and prevent the development of antibiotic resistance. Do not share this medication with others, even if they have similar symptoms. Proper disposal of any unused portion of the injection should be done as per hospital protocols.
  • In patients with kidney problems, the dosage may need to be adjusted based on creatinine clearance levels. It is also important to discuss all the medications you are currently taking with your doctor, as TAZACT 1.125GM INJECTION can interact with other drugs. Regular monitoring of kidney function and blood counts may be required during the treatment. This injection is meant for serious bacterial infections only, and its use should be reserved for situations where other antibiotics are not suitable.

Quick Tips for TAZACT 1.125GM INJECTIONArrow

  • **Complete the Full Course:** Even if you start feeling better after a few days, it's crucial to finish the entire course of Tazact 1.125gm Injection as prescribed by your doctor. Stopping prematurely can lead to antibiotic resistance and a return of the infection, potentially making it harder to treat in the future. This ensures all the bacteria are eliminated, preventing a recurrence.
  • **Inform Your Doctor of All Medications:** Before starting Tazact 1.125gm Injection, inform your doctor about all other medications you're taking, including over-the-counter drugs, herbal supplements, and vitamins. Some medications can interact with Tazact, affecting its efficacy or increasing the risk of side effects. This helps your doctor make informed decisions about your treatment plan and minimize potential complications.
  • **Stay Hydrated:** While on Tazact 1.125gm Injection, drink plenty of fluids throughout the day. This helps your kidneys function properly and aids in flushing out the medication from your system. Adequate hydration can also help alleviate some of the common side effects of antibiotics, such as nausea or diarrhea.
  • **Report Any Unusual Side Effects:** Be vigilant about monitoring for any unusual side effects while taking Tazact 1.125gm Injection. Common side effects may include nausea, diarrhea, or injection site reactions. However, if you experience more severe symptoms like difficulty breathing, swelling of the face or throat, or severe skin rash, seek immediate medical attention as these could indicate an allergic reaction.
  • **Probiotics Consideration:** Tazact 1.125gm Injection can disrupt the natural balance of bacteria in your gut, potentially leading to diarrhea or other digestive issues. Consider incorporating probiotics into your diet or taking a probiotic supplement during and after your antibiotic course. Probiotics can help restore the beneficial bacteria in your gut and minimize digestive discomfort. Consult your doctor before starting any new supplements.

Food Interactions with TAZACT 1.125GM INJECTIONArrow

  • TAZACT 1.125GM INJECTION does not typically have significant interactions with food. It can be administered without regard to meals. However, it's essential to maintain a balanced diet during treatment to support overall health and recovery. Consult your healthcare provider for personalized dietary advice.

FAQs

What is Tazact 1.125GM Injection?Arrow

Tazact 1.125GM Injection is an antibiotic used to treat various bacterial infections. It contains piperacillin and tazobactam.

What infections does Tazact 1.125GM Injection treat?Arrow

Tazact 1.125GM Injection is used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, abdominal infections, skin and soft tissue infections, and bone and joint infections.

How is Tazact 1.125GM Injection administered?Arrow

Tazact 1.125GM Injection is usually administered by a healthcare professional as an injection into a vein (intravenously).

What are the common side effects of Tazact 1.125GM Injection?Arrow

Common side effects of Tazact 1.125GM Injection may include nausea, vomiting, diarrhea, and pain or swelling at the injection site.

Is Tazact 1.125GM Injection safe for pregnant women?Arrow

Tazact 1.125GM Injection should only be used during pregnancy if clearly needed and as prescribed by a doctor.

Is Tazact 1.125GM Injection safe for breastfeeding women?Arrow

Tazact 1.125GM Injection may pass into breast milk. Breastfeeding women should consult their doctor before using this medication.

Can Tazact 1.125GM Injection interact with other medications?Arrow

Tazact 1.125GM Injection can interact with certain medications, such as anticoagulants and some other antibiotics. Tell your doctor about all medications you are taking.

What if I miss a dose of Tazact 1.125GM Injection?Arrow

If you miss a dose of Tazact 1.125GM Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and follow your regular dosing schedule.

How should Tazact 1.125GM Injection be stored?Arrow

Tazact 1.125GM Injection should be stored at room temperature, away from direct sunlight and heat. Keep it out of reach of children.

Is Tazact 1.125GM Injection a penicillin?Arrow

Yes, piperacillin present in Tazact 1.125GM Injection belongs to the penicillin class of antibiotics.

Can Tazact 1.125GM Injection cause an allergic reaction?Arrow

Yes, Tazact 1.125GM Injection can cause allergic reactions, especially in individuals with penicillin allergies. Seek immediate medical attention if you experience an allergic reaction.

How to use Tazact Injection?Arrow

Tazact Injection should only be used by a qualified healthcare professional. It is administered as an intravenous injection.

Is Tazact 1.125GM Injection effective for viral infections?Arrow

No, Tazact 1.125GM Injection is not effective against viral infections. It is only effective against bacterial infections.

Can Tazact 1.125GM Injection cause diarrhea?Arrow

Yes, Tazact 1.125GM Injection can cause diarrhea. If you experience severe or persistent diarrhea, inform your doctor.

What are the symptoms of an overdose of Tazact 1.125GM Injection?Arrow

Symptoms of an overdose of Tazact 1.125GM Injection may include seizures, confusion, and kidney problems. Seek immediate medical attention if you suspect an overdose.

References

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DrugBank: Piperacillin. This entry provides comprehensive information about Piperacillin, including its mechanism of action, pharmacokinetics, and therapeutic uses. Tazobactam is also mentioned as a combination therapy ingredient.

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DrugBank: Tazobactam. This entry provides comprehensive information about Tazobactam, including its mechanism of action as a beta-lactamase inhibitor.

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National Center for Biotechnology Information (NCBI): Piperacillin/tazobactam: a critical review. This article reviews the clinical pharmacology, spectrum of activity, and therapeutic uses of the piperacillin/tazobactam combination.

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U.S. Food and Drug Administration (FDA) Prescribing Information for Zosyn (piperacillin and tazobactam) injection. Provides detailed information regarding the drug's composition, indications, dosage, and safety.

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European Medicines Agency (EMA): Tazocin (piperacillin / tazobactam). Provides regulatory information and scientific assessment reports related to piperacillin/tazobactam.

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CIPLA PHARMACEUTICAL COMPANY LIMITED

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