TERMIN 30MG/ML INJECTION

How TERMIN 30MG/ML INJECTION Works

• TERMIN 30MG/ML INJECTION contains Terlipressin, a synthetic analogue of vasopressin, which is a naturally occurring hormone in the body. It is primarily used to manage bleeding from esophageal varices (swollen veins in the esophagus) and hepatorenal syndrome (kidney failure in patients with advanced liver disease). Terlipressin works through a multifaceted approach to achieve its therapeutic effects.
• Firstly, Terlipressin acts as a vasoconstrictor. When administered, it binds to vasopressin V1 receptors located on the smooth muscle cells of blood vessels, especially in the splanchnic circulation (blood vessels supplying the abdominal organs). This binding causes the smooth muscles to contract, leading to the constriction of these blood vessels. By constricting the splanchnic blood vessels, Terlipressin reduces blood flow to the portal venous system, which is the network of veins that carries blood from the digestive organs to the liver. This reduction in portal blood flow helps to lower portal hypertension, the elevated pressure in the portal venous system that is a primary cause of esophageal varices.
• Secondly, the reduced portal pressure alleviates the pressure on the esophageal varices, diminishing the risk of rupture and subsequent bleeding. In the event of active variceal bleeding, the vasoconstrictive effect of Terlipressin helps to slow down or stop the bleeding, providing a crucial window for other interventions such as endoscopic procedures. By controlling variceal bleeding, Terlipressin improves the patient’s overall condition and prognosis.
• Thirdly, in the context of hepatorenal syndrome, Terlipressin's vasoconstrictive action plays a vital role in improving kidney function. Patients with advanced liver disease often develop circulatory dysfunction, leading to reduced blood flow to the kidneys. By constricting blood vessels, Terlipressin increases systemic vascular resistance and raises blood pressure, which in turn improves renal perfusion (blood flow to the kidneys). This improved renal perfusion helps to restore kidney function, increases urine output, and reduces serum creatinine levels, thereby reversing hepatorenal syndrome.
• In summary, TERMIN 30MG/ML INJECTION works by reducing portal hypertension through splanchnic vasoconstriction, controlling variceal bleeding, and improving renal perfusion in patients with hepatorenal syndrome. Its mechanism of action makes it a valuable medication in the management of these severe complications of liver disease.

Possible side effects of TERMIN 30MG/ML INJECTION may include: Common side effects: Nausea, Vomiting, Diarrhea, Abdominal pain, Loss of appetite, Fatigue, Weakness, Headache, Dizziness, Hair loss, Skin rash, Injection site reactions (pain, swelling, redness). Uncommon side effects: Allergic reactions (hives, itching, swelling of the face, lips, tongue, or throat, difficulty breathing), Liver problems (yellowing of the skin or eyes, dark urine, pale stools), Kidney problems (decreased urination, swelling of the ankles or feet), Blood disorders (easy bruising or bleeding, fever, chills, sore throat), Heart problems (chest pain, shortness of breath, irregular heartbeat), Nerve problems (numbness, tingling, burning pain in the hands or feet), Lung problems (cough, shortness of breath, wheezing), Infections (fever, chills, sore throat, cough), Muscle pain, Joint pain, Mouth sores, Changes in taste, Depression, Anxiety, Insomnia. This is not an exhaustive list. If you experience any unusual symptoms, consult your doctor immediately.

• If you miss a dose of TERMIN 30MG/ML INJECTION, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
• Contact your healthcare provider for guidance if you have missed multiple doses or are concerned about the missed dose.

• Keep TERMIN 30MG INJ 10ML away from the reach of children and pets.
• Store TERMIN 30MG INJ 10ML at room temperature.

• **Understand the Purpose:** TERMIN 30MG/ML INJECTION is often used for managing post-operative nausea and vomiting (PONV). Make sure you understand why your healthcare provider has prescribed it for you or your loved one. Knowing the reason can help you be more prepared and monitor for its effectiveness.
• **Administration Details:** This medication is administered via injection by a healthcare professional. Do not attempt to self-administer TERMIN 30MG/ML INJECTION. Understanding the planned timing and location of the injection can help ease anxiety and ensure you're prepared for the process. Ask your healthcare provider about what to expect during and after the injection.
• **Potential Side Effects:** Like all medications, TERMIN can cause side effects. Common side effects may include headache, dizziness, or constipation. Discuss potential side effects with your doctor or pharmacist and know what to do if they occur. Seek immediate medical attention if you experience severe side effects like allergic reactions or difficulty breathing.
• **Drug Interactions:** Inform your healthcare provider about all medications, supplements, and herbal products you are currently taking. TERMIN can interact with other drugs, potentially affecting how it works or increasing the risk of side effects. A complete medication list will help your doctor make informed decisions about your treatment plan.
• **Monitoring and Follow-up:** Your healthcare provider will likely monitor your response to TERMIN. Attend all scheduled follow-up appointments so they can assess the effectiveness of the treatment and address any concerns you may have. These appointments are crucial for ensuring the best possible outcome and managing any potential issues that may arise during the course of treatment.
• **Storage and Handling (For Professionals):** TERMIN should be stored according to the manufacturer's instructions, typically at controlled room temperature. Healthcare professionals administering the injection should adhere to proper handling and disposal procedures for injectable medications to maintain sterility and prevent contamination.
• **Communicate with Your Healthcare Team:** Don't hesitate to communicate any concerns, questions, or changes in your condition to your healthcare team. Open communication is essential for ensuring safe and effective treatment. If you experience any unusual symptoms or have doubts about the medication, reach out to your doctor or pharmacist promptly.

• TERMIN 30MG/ML INJECTION is typically administered by a healthcare professional. There are no specific food interactions known to significantly affect the drug's efficacy or safety. However, it is generally advisable to maintain a balanced diet during treatment. Consult your doctor or healthcare provider for personalized advice based on your overall health condition and treatment plan.