TIDOMET FORTE TABLET 10'S

How TIDOMET FORTE TABLET 10'S Works

• TIDOMET FORTE TABLET 10'S is a combination medicine designed to manage the symptoms of Parkinson's disease. Its effectiveness stems from the synergistic action of its three active ingredients: Levodopa, Carbidopa, and Entacapone. Each component plays a crucial role in alleviating the motor symptoms associated with this neurodegenerative condition.
• Levodopa is a precursor to dopamine, a neurotransmitter that is deficient in the brains of individuals with Parkinson's disease. Dopamine is essential for controlling movement, coordination, and balance. By administering Levodopa, the body can convert it into dopamine, thereby replenishing the depleted levels and improving motor function. However, when Levodopa is administered alone, a significant portion of it is metabolized in the bloodstream before it can reach the brain. This metabolism reduces its effectiveness and increases the risk of side effects.
• Carbidopa, the second component of TIDOMET FORTE, addresses this issue. Carbidopa is a dopa decarboxylase inhibitor. It works by inhibiting the enzyme that breaks down Levodopa in the peripheral circulation (i.e., outside the brain). This allows a greater proportion of Levodopa to cross the blood-brain barrier, where it can be converted into dopamine in the brain. By preventing the premature breakdown of Levodopa, Carbidopa enhances its bioavailability and reduces the required dosage, which in turn minimizes peripheral side effects such as nausea and vomiting.
• Entacapone, the third ingredient, further enhances the effects of Levodopa. Entacapone is a selective and reversible catechol-O-methyltransferase (COMT) inhibitor. COMT is an enzyme that breaks down dopamine and Levodopa in the brain and peripheral tissues. By inhibiting COMT, Entacapone slows down the degradation of Levodopa, prolonging its duration of action and maintaining more stable dopamine levels in the brain. This helps to reduce the 'wearing-off' effect, a phenomenon where the benefits of Levodopa diminish before the next dose is due, leading to motor fluctuations.
• In summary, TIDOMET FORTE works through a triple-action mechanism. Levodopa provides the building blocks for dopamine synthesis, Carbidopa protects Levodopa from premature breakdown in the periphery, and Entacapone extends the duration of Levodopa's action by inhibiting its degradation. This combination ensures a more consistent and sustained dopamine supply to the brain, resulting in improved motor control, reduced symptom severity, and enhanced quality of life for individuals with Parkinson's disease. The combined effect helps in managing symptoms like tremors, stiffness, slowness of movement, and postural instability, allowing patients to perform daily activities with greater ease.

Common side effects of Tidomet Forte Tablet may include nausea, vomiting, loss of appetite, diarrhea, constipation, dry mouth, dizziness, drowsiness, lightheadedness, headache, blurred vision, difficulty sleeping (insomnia), anxiety, confusion, agitation, abnormal dreams, fatigue, weakness, muscle cramps, numbness or tingling, skin rash, itching, or changes in taste. Less common but more serious side effects can include uncontrolled movements, muscle stiffness, tremors, falls, depression, hallucinations, psychosis, suicidal thoughts, heart rhythm disturbances, changes in blood pressure, difficulty urinating, dark urine, yellowing of the skin or eyes (jaundice), and severe allergic reactions (rash, itching, swelling, dizziness, trouble breathing). Contact your doctor immediately if you experience any serious or persistent side effects.

• If you miss a dose of Tidomet Forte Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep TIDOMET FORTE TAB 1X10 away from the reach of children and pets.
• Store TIDOMET FORTE TAB 1X10 at room temperature.

• **Consistent Timing is Key:** Take TIDOMET FORTE TABLET 10'S at the same times each day to maintain a stable level of medication in your body. This helps to control your symptoms of Parkinson's disease or restless legs syndrome more effectively. Setting a daily alarm can be a helpful reminder.
• **Follow Dietary Guidelines:** Be mindful of your protein intake, as high-protein diets can sometimes interfere with the absorption of levodopa, one of the active ingredients in TIDOMET FORTE TABLET 10'S. Consult your doctor or a registered dietitian for personalized dietary recommendations to ensure optimal medication effectiveness. Try to distribute protein intake evenly throughout the day, instead of consuming large amounts at once.
• **Manage Potential Side Effects:** Be aware of potential side effects such as nausea, dizziness, or involuntary movements. If you experience any bothersome side effects, don't hesitate to contact your doctor. They may adjust your dosage or recommend strategies to manage these effects. Common strategies include taking the medication with a small snack (if nausea occurs) or adjusting the timing of doses.
• **Stay Hydrated:** Drink plenty of water throughout the day to help prevent constipation, a common side effect of some medications used to treat Parkinson's disease. Adequate hydration also supports overall health and well-being. Aim for at least 8 glasses of water daily, unless your doctor advises otherwise.
• **Don't Stop Abruptly:** Do not stop taking TIDOMET FORTE TABLET 10'S without consulting your doctor, as this can lead to withdrawal symptoms or a worsening of your condition. Your doctor will gradually reduce your dosage if it's necessary to discontinue the medication. Sudden cessation can cause serious complications, so always follow your doctor's instructions carefully.

• TIDOMET FORTE TABLET 10'S can be taken with or without food, but it's important to maintain consistency. Taking it at the same time each day, relative to your meals, can help ensure consistent absorption. High-protein meals may affect the absorption of levodopa, one of the active ingredients. If you notice any changes in the medication's effectiveness based on when you eat, discuss this with your doctor. Avoid taking this medication with iron supplements or foods high in iron, as iron can bind to levodopa and reduce its absorption.