TRAJENTA DUO 2.5/850MG TABLET 10'S

How TRAJENTA DUO 2.5/850MG TABLET 10'S Works

• TRAJENTA DUO 2.5/850MG TABLET 10'S is a combination medicine containing two active ingredients: linagliptin and metformin. These two medications work together through different mechanisms to help lower blood sugar levels in individuals with type 2 diabetes. Linagliptin belongs to a class of drugs called DPP-4 inhibitors, while metformin is a biguanide.
• Linagliptin works by increasing the amount of incretin hormones in the body. Incretin hormones, such as GLP-1 (glucagon-like peptide-1), are released by the intestine throughout the day and in response to a meal. These hormones signal the pancreas to release insulin and also signal the liver to stop producing glucose. By inhibiting the DPP-4 enzyme, linagliptin prevents the breakdown of incretin hormones, thereby prolonging their action. This leads to an increase in insulin secretion when blood sugar is high and a decrease in glucagon secretion, which reduces glucose production by the liver. The net effect is improved blood sugar control.
• Metformin, on the other hand, primarily works by decreasing glucose production in the liver and improving the body's sensitivity to insulin. It reduces the amount of glucose the liver releases into the bloodstream and helps muscle cells utilize insulin more effectively. Metformin also slows down the absorption of glucose from the intestines after a meal. It’s important to note that metformin does not typically cause hypoglycemia (low blood sugar) when used alone because it does not stimulate insulin release.
• When linagliptin and metformin are combined in TRAJENTA DUO, they provide complementary effects on blood sugar control. Linagliptin enhances insulin secretion and reduces glucagon levels by prolonging incretin hormone action, while metformin reduces glucose production in the liver and improves insulin sensitivity. This dual action helps to lower both fasting and post-meal blood sugar levels more effectively than either medication alone. The combination helps in maintaining better glycemic control throughout the day.
• It is important to use TRAJENTA DUO 2.5/850MG TABLET 10'S as part of a comprehensive diabetes management plan that includes diet and exercise. Regular monitoring of blood sugar levels is also necessary to ensure the medication is working effectively and to adjust the dosage as needed under the guidance of a healthcare professional. Potential side effects and interactions with other medications should be discussed with your doctor or pharmacist. Always follow your doctor's instructions regarding dosage and timing of this medication.

Possible side effects of TRAJENTA DUO 2.5/850MG TABLET may include: * **Common:** Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, upper respiratory tract infection symptoms (like runny nose, sore throat), hypoglycemia (low blood sugar) especially when used with other diabetes medications like sulfonylureas or insulin. * **Uncommon:** Skin rash, itching, constipation. * **Rare:** Lactic acidosis (symptoms include rapid breathing, nausea, vomiting, stomach pain), pancreatitis (severe abdominal pain radiating to the back), liver problems (yellowing of skin/eyes, dark urine, persistent fatigue), bullous pemphigoid (blistering skin condition), joint pain, muscle pain. **It is important to consult your doctor immediately if you experience any severe or persistent side effects.**

• If you miss a dose of TRAJENTA DUO 2.5/850MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep TRAJENTA DUO 2.5/850MG TAB 1X10 away from the reach of children and pets.
• Store TRAJENTA DUO 2.5/850MG TAB 1X10 at room temperature.

• Take TRAJENTA DUO 2.5/850MG TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider. Consistent adherence ensures optimal blood sugar control.
• TRAJENTA DUO 2.5/850MG TABLET 10'S should be taken with food to minimize the risk of stomach upset. This also aids in better absorption of the medication, leading to more stable blood sugar levels throughout the day.
• Regularly monitor your blood sugar levels as directed by your doctor. This will help you understand how TRAJENTA DUO 2.5/850MG TABLET 10'S is working for you and allows for timely adjustments in your treatment plan if needed. Keep a log of your readings to share with your healthcare provider.
• Stay hydrated by drinking plenty of water throughout the day while taking TRAJENTA DUO 2.5/850MG TABLET 10'S. Adequate hydration supports kidney function, which is essential for eliminating waste products and maintaining overall health, especially for individuals with diabetes.
• Be aware of the symptoms of low blood sugar (hypoglycemia), such as sweating, shaking, dizziness, and confusion. Carry a source of fast-acting sugar, like glucose tablets or fruit juice, with you at all times to treat hypoglycemia promptly. Inform your family and friends about these symptoms and how to assist you if needed. Also, understand the symptoms of high blood sugar (hyperglycemia) and what to do if they occur.
• Inform your doctor about all other medications, supplements, and herbal remedies you are taking before starting TRAJENTA DUO 2.5/850MG TABLET 10'S. Drug interactions can affect how TRAJENTA DUO works and increase the risk of side effects. This includes over-the-counter medications and any other treatments you may be receiving.
• Follow a healthy diet and exercise regularly while taking TRAJENTA DUO 2.5/850MG TABLET 10'S. This medication is most effective when combined with lifestyle modifications that support blood sugar control. Consult with a registered dietitian or certified diabetes educator for personalized guidance on diet and exercise.
• If you experience any unusual side effects, such as persistent nausea, vomiting, abdominal pain, or signs of an allergic reaction, contact your doctor immediately. Do not ignore any new or worsening symptoms, as they could indicate a serious problem.
• Store TRAJENTA DUO 2.5/850MG TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Proper storage ensures the medication remains effective and safe to use.
• Attend all scheduled follow-up appointments with your doctor and other healthcare providers. Regular check-ups allow your doctor to monitor your overall health and make any necessary adjustments to your treatment plan. These appointments are crucial for managing your diabetes effectively and preventing complications.

• TRAJENTA DUO 2.5/850MG TABLET 10'S can be taken with or without food. However, it is recommended to take it with meals to help reduce the risk of stomach upset.
• Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of lactic acidosis.