TRAMALOR TABLET 10'S

How TRAMALOR TABLET 10'S Works

• TRAMALOR TABLET 10'S contains tramadol, a synthetic opioid analgesic that works by targeting the central nervous system to relieve pain. Its mechanism of action is dual: it binds to the μ-opioid receptor and inhibits the reuptake of norepinephrine and serotonin. Binding to the μ-opioid receptor reduces the transmission of pain signals to the brain, thereby diminishing the sensation of pain. The inhibition of norepinephrine and serotonin reuptake enhances the levels of these neurotransmitters in the synaptic cleft, contributing to pain modulation. Serotonin and norepinephrine are involved in regulating mood and pain pathways in the brain. By increasing their availability, tramadol can further alleviate pain and improve overall comfort.
• When tramadol binds to the μ-opioid receptors, it mimics the effects of endogenous opioids, such as endorphins. This action reduces the perception of pain by interfering with the way pain signals are processed and interpreted by the brain. The modulation of pain signals occurs at various levels within the central nervous system, including the spinal cord and the brain itself. The involvement of the noradrenergic and serotonergic systems provides an additional layer of pain relief, especially for chronic pain conditions. This dual-action mechanism makes tramadol effective in managing moderate to severe pain, often used post-operatively or for chronic conditions like osteoarthritis.
• Tramadol's dual-action sets it apart from traditional opioid analgesics. By not only binding to opioid receptors but also influencing neurotransmitter levels, it offers a multifaceted approach to pain management. The reuptake inhibition of norepinephrine and serotonin boosts the body's natural pain-fighting mechanisms. This comprehensive action helps reduce the reliance on a single pain pathway, potentially lowering the risk of tolerance and dependence compared to pure opioid agonists. As a result, TRAMALOR TABLET 10'S can provide significant pain relief, improving patients' quality of life by reducing discomfort and enhancing their ability to perform daily activities.
• The effectiveness of TRAMALOR TABLET 10'S depends on individual factors, such as the severity of pain, the patient's overall health, and any other medications they may be taking. It is essential to take TRAMALOR TABLET 10'S as prescribed by a healthcare professional to maximize its benefits and minimize the risk of side effects. Common side effects may include nausea, dizziness, drowsiness, and constipation. Patients should be aware of these potential effects and consult their doctor if they experience any severe or persistent symptoms. With proper use, TRAMALOR TABLET 10'S can be a valuable tool in managing moderate to severe pain, enabling patients to live more comfortably and actively.
• In summary, TRAMALOR TABLET 10'S offers pain relief through a dual-action mechanism. By binding to μ-opioid receptors and inhibiting the reuptake of norepinephrine and serotonin, it effectively reduces pain signals and enhances the body's natural pain-fighting capabilities. This combined action makes it a useful option for managing various types of pain, from post-operative discomfort to chronic conditions. Always follow your doctor's instructions when taking TRAMALOR TABLET 10'S to ensure safe and effective pain management.

Like all medicines, TRAMALOR TABLET 10'S can cause side effects, although not everybody gets them. **Very Common (may affect more than 1 in 10 people):** * Nausea * Dizziness **Common (may affect up to 1 in 10 people):** * Vomiting * Headache * Drowsiness * Constipation * Dry mouth * Sweating * Fatigue **Uncommon (may affect up to 1 in 100 people):** * Effects on circulation (palpitations, fast heartbeat, feeling faint or collapse). These effects are more likely to occur when tramadol is given intravenously or after physical strain. * Retching * Stomach irritation (a feeling of pressure in the stomach, bloating) * Diarrhea * Skin reactions (e.g. itching, rash, hives) **Rare (may affect up to 1 in 1,000 people):** * Allergic reactions (e.g. difficulty breathing, wheezing, swelling of the skin) and shock have occurred in very rare cases. If you experience any of these, stop taking TRAMALOR TABLET 10'S and consult a doctor immediately. * Slow heartbeat * Increase in blood pressure * Abnormal sensations (e.g. itching, tingling, numbness) * Muscle weakness * Tremor * Changes in appetite * Difficulty passing urine * Blurred vision * Slow breathing * Epileptic fits have occurred mainly at high doses of tramadol or when tramadol is taken at the same time as other medicines which may lower the seizure threshold * Hallucinations, confusion, sleep disturbances, delirium, anxiety and nightmares **Very Rare (may affect up to 1 in 10,000 people):** * Increase in liver enzyme values **Not known (frequency cannot be estimated from the available data):** * Decrease in blood sugar level **Psychiatric side effects** may occur after treatment with TRAMALOR TABLET 10'S. These may vary individually in intensity and nature. These may present as: * Changes in mood (mostly high spirits, occasionally irritated mood) * Changes in activity (slowing down, but sometimes an increase in activity) * Less awareness If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

• If you miss a dose of Tramalor Tablet 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep TRAMALOR TAB 1X10 away from the reach of children and pets.
• Store TRAMALOR TAB 1X10 at room temperature.

• Take TRAMALOR TABLET 10'S exactly as prescribed by your doctor. Do not increase the dose or frequency without consulting them, as it can lead to serious side effects or reduced effectiveness. Always follow the prescribed dosage to manage pain effectively and safely.
• Inform your doctor about all other medications, supplements, or herbal products you are currently taking before starting TRAMALOR TABLET 10'S. This helps prevent potential drug interactions that could affect how the medication works or increase the risk of side effects. Be especially cautious with other pain relievers, sedatives, or antidepressants.
• Be aware of potential side effects such as nausea, constipation, dizziness, drowsiness, or headache while taking TRAMALOR TABLET 10'S. If any of these side effects become severe or persistent, notify your doctor promptly. Managing side effects can improve your overall comfort during treatment.
• Avoid alcohol consumption while taking TRAMALOR TABLET 10'S, as it can enhance the sedative effects of the medication and increase the risk of respiratory depression. This combination can be dangerous and should be avoided to ensure your safety and well-being.
• Store TRAMALOR TABLET 10'S at room temperature, away from moisture and direct sunlight. Keep the medication out of reach of children and pets to prevent accidental ingestion. Proper storage ensures the medication remains effective and safe to use until its expiration date.