TRIMIUM INHELAR

How TRIMIUM INHELAR Works

• TRIMIUM INHELAR is a combination medication meticulously formulated to manage and alleviate the symptoms of chronic obstructive pulmonary disease (COPD). It synergistically combines three active ingredients: Tiotropium, Olodaterol, and Inhalational Corticosteroid, each contributing uniquely to the overall therapeutic effect. Understanding the mechanism of each component provides valuable insight into how TRIMIUM INHELAR works to improve breathing and quality of life for COPD patients.
• Tiotropium is a long-acting anticholinergic bronchodilator. It works by blocking the action of acetylcholine, a neurotransmitter that causes the muscles around the airways to tighten. By blocking acetylcholine, Tiotropium relaxes these muscles, leading to bronchodilation, or widening of the airways. This makes it easier for air to flow in and out of the lungs, reducing breathlessness and wheezing. The long-acting nature of Tiotropium provides sustained bronchodilation, offering relief for up to 24 hours with a single dose.
• Olodaterol is a long-acting beta2-adrenergic agonist (LABA). It functions by stimulating beta2-adrenergic receptors in the smooth muscle cells of the airways. This stimulation triggers a cascade of intracellular events that ultimately relax the airway muscles, resulting in bronchodilation. Similar to Tiotropium, Olodaterol's bronchodilatory effect helps to improve airflow and reduce the symptoms of COPD, such as shortness of breath and chest tightness. The combination of a LABA with an anticholinergic provides a complementary and more robust bronchodilatory effect compared to either medication alone.
• Inhalational Corticosteroid works by reducing inflammation in the airways. COPD is often characterized by chronic inflammation, which contributes to airway narrowing and mucus production. Inhaled corticosteroids suppress the inflammatory response by inhibiting the release of inflammatory mediators and reducing the activity of inflammatory cells in the lungs. By reducing inflammation, Inhalational Corticosteroid helps to improve airflow, reduce exacerbations (flare-ups) of COPD symptoms, and prevent further damage to the airways.
• In summary, TRIMIUM INHELAR's triple action—bronchodilation from Tiotropium and Olodaterol, and inflammation reduction from Inhalational Corticosteroid—addresses the key underlying mechanisms of COPD. By relaxing airway muscles and reducing inflammation, TRIMIUM INHELAR helps to open up the airways, making it easier to breathe. This can lead to a significant improvement in lung function, a reduction in COPD symptoms, and a better overall quality of life for individuals living with this chronic condition. It is important to use TRIMIUM INHELAR exactly as prescribed by your doctor for optimal results.

Like all medicines, TRIMIUM INHELAR can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Sore throat * Hoarseness * Headache * Oral thrush (a fungal infection of the mouth) **Uncommon side effects (may affect up to 1 in 100 people):** * Cough * Dry mouth * Difficulty swallowing * Dizziness * Tremor * Nervousness * Sleep disturbances * Fast heartbeat * Palpitations * Changes in taste * Blurred vision * Nausea * Muscle cramps * Agitation * Increased sweating **Rare side effects (may affect up to 1 in 1,000 people):** * Tightness in the chest, wheezing, coughing and shortness of breath immediately after inhalation (paradoxical bronchospasm) * Irregular heartbeat * Allergic reactions, such as skin rash, itching, hives, swelling of the face, lips, tongue or throat **Very rare side effects (may affect up to 1 in 10,000 people):** * Increased pressure in the eyes (glaucoma) * Cataracts * Anxiety * Changes in blood pressure **Other side effects (frequency not known):** * Worsening of existing infection * Hyperactivity * Depression * Aggression * Difficulty sleeping * Bronchitis * Pneumonia **Important:** If you experience any of the following serious side effects, stop using TRIMIUM INHELAR and seek immediate medical attention: * Sudden wheezing or difficulty breathing (paradoxical bronchospasm). * Signs of an allergic reaction (e.g., rash, swelling). * New or worsening eye problems (e.g., glaucoma, blurred vision).

• If you forget to take a dose of TRIMIUM INHELAR, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Keep TRIMIUM INHELAR away from the reach of children and pets.
• Store TRIMIUM INHELAR at room temperature.

• **Master Your Inhaler Technique:** Ensure you're using your TRIMIUM INHELAR correctly. A pharmacist or healthcare provider can demonstrate the proper technique, which includes exhaling fully, creating a tight seal around the mouthpiece, inhaling deeply and steadily while activating the inhaler, and holding your breath for 10 seconds. Correct technique ensures you receive the full dose of medication.
• **Consistent Daily Use is Key:** Use TRIMIUM INHELAR every day as prescribed, even if you feel well. This medication is designed to prevent symptoms and reduce the frequency of flare-ups. Skipping doses can increase your risk of experiencing breathing difficulties.
• **Rinse Your Mouth After Each Use:** After using TRIMIUM INHELAR, rinse your mouth thoroughly with water and spit it out. This helps to prevent common side effects such as oral thrush (a fungal infection in the mouth) and hoarseness.
• **Keep Your Inhaler Clean:** Regularly clean your TRIMIUM INHELAR device as instructed in the product information leaflet. This prevents blockage and ensures optimal medication delivery. Do not immerse the inhaler in water.
• **Monitor Your Symptoms and Track Usage:** Keep a record of your symptoms, peak flow readings (if applicable), and inhaler usage. This information can help your doctor assess how well your medication is working and make adjustments to your treatment plan if needed. Contact your doctor if your symptoms worsen or if you need to use your rescue inhaler more frequently than usual.
• **Understand Potential Side Effects:** Be aware of the possible side effects of TRIMIUM INHELAR, which may include throat irritation, cough, headache, or palpitations. If you experience any bothersome or persistent side effects, consult your doctor.
• **Carry a Rescue Inhaler:** Always carry your rescue inhaler (such as albuterol) with you. TRIMIUM INHELAR is a maintenance medication and does not provide immediate relief of acute breathing difficulties. Use your rescue inhaler if you experience sudden wheezing, shortness of breath, or chest tightness.
• **Store Your Inhaler Properly:** Store TRIMIUM INHELAR in a cool, dry place away from direct sunlight and heat. Extreme temperatures can affect the medication's effectiveness.
• **Check the Expiration Date:** Regularly check the expiration date on your TRIMIUM INHELAR. Using expired medication may not provide the intended therapeutic benefits.
• **Consult Your Doctor Regularly:** Schedule regular check-ups with your doctor to discuss your asthma or COPD management. Your doctor can assess your lung function, review your medication regimen, and provide guidance on managing your condition effectively.

• There are no known interactions between TRIMIUM INHELAR and food. TRIMIUM INHELAR can be taken with or without food. However, it is always recommended to follow your doctor's instructions regarding the use of this medicine.