TRIPLIXAM TABLET 10'S

How TRIPLIXAM TABLET 10'S Works

• TRIPLIXAM TABLET 10'S is a combination medication designed to manage hypertension (high blood pressure). It combines three active ingredients – perindopril arginine, indapamide, and amlodipine – each working through a distinct mechanism to lower blood pressure effectively.
• Perindopril arginine belongs to a class of drugs called ACE (angiotensin-converting enzyme) inhibitors. ACE inhibitors work by blocking the action of ACE, an enzyme that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, increasing blood pressure. By inhibiting ACE, perindopril arginine reduces the production of angiotensin II, leading to vasodilation (widening of blood vessels). This vasodilation helps lower blood pressure and reduces the workload on the heart.
• Indapamide is a thiazide-like diuretic, often referred to as a 'water pill.' It works by increasing the excretion of sodium and water from the body through the kidneys. This reduces the volume of fluid in the bloodstream, which in turn lowers blood pressure. Indapamide primarily acts on the distal convoluted tubule in the kidneys, inhibiting sodium reabsorption. This results in more sodium and water being excreted in the urine, leading to a decrease in blood volume and a subsequent reduction in blood pressure. Indapamide also has some vasodilatory effects, further contributing to its blood pressure-lowering capabilities.
• Amlodipine is a calcium channel blocker. It works by blocking the entry of calcium into the smooth muscle cells of blood vessel walls and heart muscle cells. Calcium is essential for muscle contraction, so by blocking its entry, amlodipine causes the smooth muscles in blood vessels to relax. This relaxation leads to vasodilation, which lowers blood pressure. In the heart, amlodipine reduces the force of contraction, decreasing the heart's oxygen demand. This is particularly beneficial for individuals with angina (chest pain).
• In summary, TRIPLIXAM TABLET 10'S works through the combined actions of its three active ingredients: perindopril arginine dilates blood vessels by inhibiting ACE, indapamide reduces blood volume by increasing sodium and water excretion, and amlodipine relaxes blood vessels by blocking calcium channels. This triple-action approach provides a comprehensive and effective way to manage hypertension and reduce the risk of cardiovascular complications.
• The synergistic effect of these three medications allows for better blood pressure control than if each medication were used alone. This combination often allows patients to achieve their target blood pressure with lower doses of each individual medication, potentially reducing the risk of side effects. However, it is essential to take TRIPLIXAM TABLET 10'S exactly as prescribed by your doctor and to attend regular check-ups to monitor your blood pressure and overall health.

Like all medicines, Triplixam can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Low potassium in the blood (hypokalemia) * Increased cholesterol in the blood (hypercholesterolemia) * Increased uric acid in the blood (hyperuricemia) * Impaired glucose tolerance * Dizziness * Headache * Visual impairment * Tinnitus (ringing in the ears) * Hypotension (low blood pressure) * Cough * Dyspnea (difficulty breathing) * Gastrointestinal disorders: nausea, vomiting, abdominal pain, taste disturbance, dyspepsia or difficulty with digestion, diarrhea, constipation * Allergic reactions: maculopapular rash * Muscle spasms * Fatigue * Asthenia (weakness) **Uncommon side effects (may affect up to 1 in 100 people):** * Insomnia * Depression * Somnolence (sleepiness) * Vertigo * Palpitations * Tachycardia (rapid heartbeat) * Postural hypotension (low blood pressure upon standing) * Dry mouth * Urticaria (hives) * Pruritus (itching) * Rash * Angioedema (symptoms such as wheezing, swelling of the face, tongue or throat) * Renal problems * Impotence * Hyperhidrosis (excessive sweating) * Photosensitivity reactions (increased sensitivity of the skin to the sun) * Arthralgia (joint pain) * Myalgia (muscle pain) * Chest pain * Malaise * Peripheral edema (swelling of the extremities) * Increased urea in the blood * Increased creatinine in the blood * Falls **Rare side effects (may affect up to 1 in 1,000 people):** * Confusion * Worsening of psoriasis * Decreased chloride in the blood (hypochloremia) * Decreased magnesium in the blood (hypomagnesemia) * Arrhythmia (irregular heartbeat) * Acute renal failure * Dark urine, feeling sick (nausea) or being sick (vomiting), muscle cramps, confusion and seizures. These may be symptoms of SIADH (syndrome of inappropriate anti-diuretic hormone secretion). * Anuria (absence of urine production) * Erythema multiforme **Very rare side effects (may affect up to 1 in 10,000 people):** * Leukopenia (decrease in white blood cells) * Neutropenia (decrease in neutrophils) * Agranulocytosis (severe decrease in white blood cells) * Thrombocytopenia (decrease in platelets) * Anemia (decrease in red blood cells) * Pancytopenia (decrease in all blood cell types) * Hypercalcemia (increased calcium in the blood) * Neuropathy (nerve damage) * Stroke, possibly secondary to excessive hypotension * Vasculitis (inflammation of blood vessels) * Pancreatitis (inflammation of the pancreas) * Hepatitis (inflammation of the liver) **Not known (frequency cannot be estimated from the available data):** * Hepatic encephalopathy (brain damage caused by liver disease) * Tremor, rigid posture, mask-like face, slow movements and a shuffling, unbalanced walk * Finger or toe numbness and pain (Raynaud’s phenomenon) * If you suffer from systemic lupus erythematosus (a type of collagen disease), this might get worse. * Abnormal ECG heart tracing * Increased levels of hepatic enzymes * Potentially fatal irregular heart rhythm (Torsades de pointes) * Concentrated urine (dark in color), feel or are sick, have muscle cramps, confusion and fits which may be due to inappropriate ADH (anti-diuretic hormone) secretion can occur with ACE inhibitors. If you have these symptoms contact your doctor as soon as possible. * Myopia (nearsightedness) * Blurred vision * Visual impairment * Skin cancer (non-melanoma skin cancer)

• If you miss a dose of Triplixam, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Keep TRIPLIXAM TAB 1X10 away from the reach of children and pets.
• Store TRIPLIXAM TAB 1X10 at room temperature.

• Take TRIPLIXAM TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting your healthcare provider. This ensures you receive the optimal therapeutic benefit and minimizes the risk of side effects. Consistency is key for effective blood pressure management.
• Monitor your blood pressure regularly while taking TRIPLIXAM TABLET 10'S. Keep a log of your readings and share them with your doctor during follow-up appointments. This helps your doctor assess the effectiveness of the medication and make any necessary adjustments to your treatment plan. Home blood pressure monitoring provides valuable insights into your cardiovascular health.
• Inform your doctor about all other medications, supplements, and herbal products you are taking before starting TRIPLIXAM TABLET 10'S. Drug interactions can affect how TRIPLIXAM works or increase the risk of side effects. This includes over-the-counter medications and herbal remedies. A comprehensive medication list ensures your doctor can make informed decisions about your care.
• Maintain a healthy lifestyle while taking TRIPLIXAM TABLET 10'S. This includes eating a balanced diet, exercising regularly, and avoiding smoking and excessive alcohol consumption. These lifestyle modifications can enhance the effectiveness of TRIPLIXAM and improve your overall cardiovascular health. A holistic approach to health is crucial for managing hypertension.
• Be aware of potential side effects of TRIPLIXAM TABLET 10'S, such as dizziness, headache, or cough. If you experience any bothersome or persistent side effects, contact your doctor immediately. Do not stop taking TRIPLIXAM without consulting your doctor, as this could lead to a sudden increase in blood pressure. Promptly addressing side effects ensures your comfort and safety.

• TRIPLIXAM TABLET 10'S can be taken with or without food, but it is important to take it at the same time each day to maintain consistent blood levels of the medication. Avoid consuming large amounts of potassium-rich foods (e.g., bananas, spinach) or salt substitutes containing potassium without consulting your doctor, as TRIPLIXAM can increase potassium levels in the body. Grapefruit and grapefruit juice should be avoided as they can interact with one of the medications in TRIPLIXAM, potentially increasing its effects.
• Always follow your doctor's specific instructions regarding diet while taking TRIPLIXAM.