VCZ CHEWABLE TABLET 15'S

How VCZ CHEWABLE TABLET 15'S Works

• VCZ Chewable Tablets 15's contain voriconazole, an antifungal medication that belongs to the triazole class. It works primarily by inhibiting the synthesis of ergosterol, a crucial component of the fungal cell membrane. Ergosterol is essential for maintaining the structure and function of the fungal cell membrane; without it, the membrane becomes unstable and leaky, ultimately leading to fungal cell death. Voriconazole achieves this by binding to and inhibiting the enzyme lanosterol 14-alpha-demethylase, which is responsible for converting lanosterol to ergosterol.
• Specifically, voriconazole's mechanism involves disrupting the cytochrome P450-dependent enzyme system in fungi. This enzyme system is vital for the demethylation step in ergosterol biosynthesis. By blocking this step, voriconazole prevents the formation of ergosterol, leading to a buildup of lanosterol and other sterol precursors. This accumulation disrupts the integrity of the fungal cell membrane, increasing its permeability and causing essential cellular components to leak out. The compromised cell membrane also affects the function of membrane-bound enzymes and transport proteins, further impairing the fungus's ability to survive and replicate.
• The chewable tablet formulation of VCZ is designed for ease of administration, particularly in patients who have difficulty swallowing pills. Once ingested, voriconazole is absorbed into the bloodstream, where it is distributed throughout the body to reach the site of fungal infection. The drug's effectiveness depends on achieving adequate concentrations at the site of infection. Voriconazole exhibits broad-spectrum antifungal activity, meaning it is effective against a wide range of fungal pathogens, including Aspergillus, Candida, Fusarium, and Scedosporium species. Its targeted mechanism of action and broad spectrum make it a valuable treatment option for various invasive fungal infections. The metabolism of voriconazole primarily occurs in the liver, so caution is advised when administering this medication to patients with hepatic impairment.
• In summary, VCZ Chewable Tablets work by targeting a critical step in fungal cell membrane synthesis, leading to cell membrane disruption and fungal cell death. This mechanism, combined with its broad spectrum of activity and convenient chewable formulation, makes it an effective option for treating a variety of fungal infections.

Possible side effects of VCZ Chewable Tablet may include: Common side effects: Nausea, vomiting, diarrhea, abdominal pain, headache, fever, rash. Uncommon side effects: Changes in liver function tests, visual disturbances (blurred vision, altered color perception), dizziness, skin reactions (e.g., itching, redness), peripheral edema, fatigue, weakness, hair loss, anxiety, depression, sleep disturbances, decreased appetite. Rare side effects: Severe allergic reactions (anaphylaxis), severe skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis), liver damage, kidney problems, heart rhythm abnormalities, pancreatitis, seizures, tremor, numbness or tingling, muscle pain, joint pain, hallucinations, confusion, changes in blood counts (e.g., low white blood cell count, low platelet count). If you experience any side effects, especially severe or persistent ones, consult your doctor.

• If you forget to take a dose of VCZ Chewable Tablet 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep VCZ CHEWABLE TAB 1X15 away from the reach of children and pets.
• Store VCZ CHEWABLE TAB 1X15 at room temperature.

• VCZ CHEWABLE TABLET 15'S should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Taking this medicine with food may reduce its absorption and effectiveness.