ZITA PIO MET 1000/20/15MG TABLET 10'S

How ZITA PIO MET 1000/20/15MG TABLET 10'S Works

• ZITA PIO MET 1000/20/15MG TABLET 10'S is a combination medicine designed to manage type 2 diabetes effectively. It combines three active ingredients: Sitagliptin, Pioglitazone, and Metformin, each working through different mechanisms to control blood sugar levels. This multi-pronged approach helps achieve better glycemic control compared to using a single medication.
• Metformin, present at 1000mg, is a biguanide that primarily reduces glucose production in the liver. It achieves this by suppressing hepatic gluconeogenesis, the process by which the liver generates glucose from non-carbohydrate sources. Additionally, Metformin improves insulin sensitivity in peripheral tissues like muscles, allowing them to utilize glucose more efficiently. This increased glucose uptake by the muscles helps lower blood sugar levels. Furthermore, Metformin slows down the absorption of glucose from the intestines after a meal, preventing sharp spikes in blood sugar.
• Pioglitazone, at 15mg, belongs to the thiazolidinedione (TZD) class of drugs. It acts as an insulin sensitizer, primarily by activating peroxisome proliferator-activated receptor gamma (PPARγ). PPARγ receptors are found in adipose tissue, muscle, and liver. Activation of these receptors enhances insulin sensitivity in these tissues, allowing insulin to work more effectively. This means that cells are better able to take up glucose from the bloodstream in response to insulin, leading to lower blood sugar levels. Pioglitazone also helps to reduce hepatic glucose production, further contributing to its blood sugar-lowering effect. In addition to its effects on glucose metabolism, Pioglitazone can also affect lipid metabolism and may improve certain aspects of cardiovascular health.
• Sitagliptin, at 20mg, is a dipeptidyl peptidase-4 (DPP-4) inhibitor. DPP-4 is an enzyme that inactivates incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These incretin hormones are released from the gut in response to food intake and play a crucial role in regulating blood sugar levels. GLP-1, for example, stimulates insulin release from the pancreas, suppresses glucagon secretion (which raises blood sugar), and slows gastric emptying. By inhibiting DPP-4, Sitagliptin increases the levels of active incretin hormones in the body. This leads to increased insulin secretion and decreased glucagon secretion in a glucose-dependent manner, meaning that these effects are more pronounced when blood sugar levels are high. The overall effect is improved blood sugar control, particularly after meals.
• In summary, ZITA PIO MET 1000/20/15MG TABLET 10'S works by addressing multiple aspects of type 2 diabetes. Metformin reduces glucose production in the liver and improves insulin sensitivity, Pioglitazone enhances insulin sensitivity in peripheral tissues, and Sitagliptin increases incretin hormone levels, leading to increased insulin secretion and decreased glucagon secretion. This combination therapy provides a comprehensive approach to managing blood sugar levels and improving glycemic control in patients with type 2 diabetes.

The following side effects may occur while taking ZITA PIO MET 1000/20/15MG TABLET. Not all side effects are listed, and the frequency of side effects can vary from person to person. It is important to consult with your doctor if you experience any concerning side effects. **Common Side Effects:** * Nausea * Vomiting * Diarrhea * Abdominal pain or discomfort * Loss of appetite * Headache * Dizziness * Metallic taste in the mouth * Edema (swelling), particularly in the legs and ankles * Upper respiratory tract infection * Weight gain **Uncommon Side Effects:** * Hypoglycemia (low blood sugar), especially when used with other diabetes medications * Visual disturbances * Anemia * Joint pain * Muscle pain * Increased risk of bone fractures (particularly in women) * Liver problems (rare but serious) * Allergic reactions (rash, itching, hives) * Macular edema (fluid accumulation in the macula of the eye) * Heart failure (in susceptible individuals) * Lactic acidosis (rare but serious, symptoms include muscle pain, weakness, numbness, trouble breathing, stomach pain, nausea, vomiting, slow or irregular heart rate). **Important Note:** This is not an exhaustive list. Contact your doctor or pharmacist for a complete list and medical advice regarding side effects.

• If you miss a dose of ZITA PIO MET 1000/20/15MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep ZITA PIO MET 1000/20/15MG TAB 1X10 away from the reach of children and pets.
• Store ZITA PIO MET 1000/20/15MG TAB 1X10 at room temperature.

• Take ZITA PIO MET 1000/20/15MG TABLET exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider, as this can affect your blood sugar levels.
• It is best to take ZITA PIO MET 1000/20/15MG TABLET with food to minimize the risk of stomach upset. Consistent timing with meals can also help maintain stable blood sugar levels throughout the day.
• Regularly monitor your blood sugar levels as directed by your doctor. Keep a record of your readings and share them with your healthcare provider during your appointments. This helps in assessing how well the medication is working and if any adjustments are needed.
• Follow a healthy diet and exercise regularly while taking ZITA PIO MET 1000/20/15MG TABLET. A balanced diet low in sugars and carbohydrates, combined with regular physical activity, can significantly improve blood sugar control and overall health. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
• Be aware of the symptoms of low blood sugar (hypoglycemia), such as shakiness, sweating, dizziness, and confusion. Carry a quick source of sugar, like glucose tablets or fruit juice, with you at all times in case your blood sugar drops too low. Inform your family and friends about the signs of hypoglycemia and how to assist you if needed.
• Stay well-hydrated by drinking plenty of water throughout the day. Adequate hydration is important for overall health and can also help manage blood sugar levels effectively. Limit sugary drinks and opt for water or unsweetened beverages instead.
• Inform your doctor about all other medications, supplements, and herbal products you are taking. Some medications can interact with ZITA PIO MET 1000/20/15MG TABLET, potentially affecting its efficacy or increasing the risk of side effects. Your doctor can help manage any potential interactions.
• Attend all scheduled appointments with your doctor and undergo regular check-ups, including blood tests and kidney function tests. These tests help monitor your overall health and assess the effectiveness of the medication, allowing for timely adjustments if necessary.
• Store ZITA PIO MET 1000/20/15MG TABLET in a cool, dry place away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Check the expiration date and dispose of any expired medication properly.
• If you experience any persistent or severe side effects, such as nausea, vomiting, diarrhea, or unusual muscle pain, contact your doctor immediately. These symptoms may indicate a serious adverse reaction that requires medical attention.

• ZITA PIO MET 1000/20/15MG TABLET 10'S can be taken with or without food, but it is generally recommended to take it with meals to minimize the risk of gastrointestinal side effects such as nausea, vomiting, or diarrhea. Consistent timing with meals can also help maintain stable blood sugar levels.
• Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of lactic acidosis, a rare but serious side effect. Alcohol can also interfere with blood sugar control.