ZOMELIS P TABLET 15'S

How ZOMELIS P TABLET 15'S Works

• ZOMELIS P Tablet 15'S is a combination medication containing two active ingredients: Metformin and Pioglitazone. These components work synergistically to improve blood sugar control in individuals with type 2 diabetes mellitus. Metformin primarily reduces glucose production in the liver and enhances insulin sensitivity in peripheral tissues, such as muscles, allowing cells to utilize glucose more effectively. It achieves this by inhibiting hepatic gluconeogenesis, the process by which the liver generates glucose from non-carbohydrate sources. Additionally, Metformin slows down the absorption of glucose from the intestines, further contributing to lower blood sugar levels. It also increases the activity of AMP-activated protein kinase (AMPK), a key enzyme involved in regulating energy balance and glucose metabolism.
• Pioglitazone, on the other hand, belongs to a class of drugs called thiazolidinediones (TZDs). It functions by improving insulin sensitivity in peripheral tissues, including adipose tissue and muscles. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor that plays a crucial role in regulating glucose and lipid metabolism. By activating PPARγ, Pioglitazone enhances the uptake and utilization of glucose in these tissues, leading to a decrease in insulin resistance. It also helps to reduce the production of glucose in the liver, although to a lesser extent than Metformin. Furthermore, Pioglitazone can improve lipid profiles by increasing HDL cholesterol and decreasing triglycerides.
• The combined action of Metformin and Pioglitazone in ZOMELIS P Tablet 15'S addresses multiple aspects of insulin resistance and glucose metabolism dysfunction seen in type 2 diabetes. Metformin tackles excessive glucose production in the liver and poor glucose uptake in muscles, while Pioglitazone enhances insulin sensitivity in peripheral tissues and also modulates liver glucose production and lipid metabolism. This dual mechanism helps to lower both fasting and postprandial blood sugar levels. The enhanced insulin sensitivity also leads to a better response to the body's own insulin, which can delay or prevent the need for higher doses of medication or insulin injections. It is important to note that ZOMELIS P Tablet 15'S is most effective when used in conjunction with a healthy diet and regular exercise.

Common side effects of Zomelis P Tablet may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and metallic taste. Some patients may also experience hypoglycemia (low blood sugar), headache, dizziness, and fatigue. Less common side effects could involve skin rash, itching, constipation, flatulence, and upper respiratory tract infection. Rare but serious side effects include pancreatitis, liver problems, and lactic acidosis. If you experience any severe or persistent side effects, discontinue use and consult your doctor immediately. This is not an exhaustive list, and other side effects may occur.

• If you miss a dose of ZOMELIS P TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep ZOMELIS P 15/100MG TAB 1X15 away from the reach of children and pets.
• Store ZOMELIS P 15/100MG TAB 1X15 at room temperature.

• Take Zomelis P Tablet 15's exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. Consistent adherence to the prescribed regimen optimizes blood sugar control and minimizes the risk of side effects.
• Monitor your blood sugar levels regularly as advised by your healthcare provider while taking Zomelis P Tablet 15's. Keeping a log of your readings helps you and your doctor assess the effectiveness of the medication and make necessary adjustments to your treatment plan. Understanding how your body responds to the medication is key for diabetes management.
• Zomelis P Tablet 15's is most effective when combined with a healthy lifestyle. This includes a balanced diet, regular physical activity, and maintaining a healthy weight. Focus on incorporating whole grains, lean proteins, fruits, and vegetables into your meals while limiting processed foods, sugary drinks, and unhealthy fats. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
• Be aware of the potential side effects of Zomelis P Tablet 15's and know when to seek medical attention. Common side effects may include gastrointestinal discomfort such as nausea, diarrhea, or abdominal pain. More serious side effects, though rare, could include allergic reactions or liver problems. Report any unusual symptoms to your doctor promptly.
• Inform all your healthcare providers, including your dentist, that you are taking Zomelis P Tablet 15's. This is important because Zomelis P Tablet 15's can interact with other medications or affect certain medical procedures. Always keep an updated list of all medications and supplements you are taking.
• Store Zomelis P Tablet 15's in a cool, dry place away from direct sunlight and moisture. Ensure the medication is kept out of reach of children and pets. Proper storage helps maintain the drug's efficacy and prevents accidental ingestion.
• If you miss a dose of Zomelis P Tablet 15's, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one, as this can increase the risk of side effects.

• ZOMELIS P TABLET 15'S can be taken with or without food, but it is generally recommended to take it at a fixed time to maintain consistent blood sugar levels. High-fat meals may delay the absorption of the medication, potentially affecting its onset of action. Consult your doctor or pharmacist for specific dietary advice related to your treatment.