GLUCRETA S 5/100MG TABLET 10'S

How GLUCRETA S 5/100MG TABLET 10'S Works

• GLUCRETA S 5/100MG TABLET 10'S is a combination medication designed to effectively manage type 2 diabetes. It combines two active ingredients: sitagliptin and metformin, each working through different mechanisms to lower blood glucose levels and improve glycemic control. Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, while metformin is a biguanide.
• Sitagliptin enhances the body's natural ability to lower blood sugar. After a meal, the body releases incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). These hormones stimulate the pancreas to release insulin and signal the liver to stop producing excessive glucose. DPP-4 enzymes break down incretin hormones. Sitagliptin inhibits the action of DPP-4, thereby increasing the levels of active incretin hormones in the body. This results in increased insulin release when blood sugar is high and decreased glucagon secretion, which reduces glucose production by the liver.
• Metformin works primarily by decreasing glucose production in the liver and improving the body's sensitivity to insulin. It reduces hepatic glucose production by inhibiting gluconeogenesis (the production of glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Additionally, metformin increases insulin sensitivity in peripheral tissues such as muscle, allowing cells to utilize glucose more effectively. Metformin also slows down the absorption of glucose from the intestines.
• By combining sitagliptin and metformin, GLUCRETA S 5/100MG TABLET 10'S provides a dual-action approach to managing blood sugar levels. Sitagliptin addresses the hormonal regulation of glucose, while metformin targets glucose production and insulin sensitivity. This synergistic effect can lead to better glycemic control than either medication used alone. The combination helps to lower both fasting and postprandial (after-meal) blood sugar levels, contributing to improved long-term diabetes management and reduced risk of diabetes-related complications. It is important to take GLUCRETA S 5/100MG TABLET 10'S as prescribed by your healthcare provider and to follow a healthy diet and exercise plan to maximize its benefits.

Possible side effects of GLUCRETA S 5/100MG TABLET 10'S may include: * **Common Side Effects:** Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weakness, fatigue, hypoglycemia (low blood sugar), skin rash, itching. * **Uncommon Side Effects:** Constipation, flatulence, bloating, heartburn, abnormal liver function tests, jaundice, muscle pain, joint pain, blurred vision, swelling of ankles and feet, increased sweating, weight gain, anemia, thrombocytopenia (low platelet count), allergic reactions (e.g., hives, angioedema). * **Rare Side Effects:** Severe allergic reactions (anaphylaxis), liver failure, pancreatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, lactic acidosis (rare but serious).

• If you miss a dose of GLUCRETA S 5/100MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep GLUCRETA S 5/100MG TAB 1X10 away from the reach of children and pets.
• Store GLUCRETA S 5/100MG TAB 1X10 at room temperature.

• Take GLUCRETA S 5/100MG TABLET 10'S as prescribed by your doctor, usually once or twice daily with meals. Consistency is key for optimal blood sugar control. Don't skip doses, and try to take it at the same time each day to maintain a steady level of medication in your body.
• Inform your doctor about all other medications, supplements, and herbal remedies you're taking. GLUCRETA S 5/100MG TABLET 10'S can interact with other drugs, potentially affecting its efficacy or increasing the risk of side effects. This includes over-the-counter medications.
• Monitor your blood sugar levels regularly, as directed by your healthcare provider. This helps you and your doctor assess how well the medication is working and make any necessary adjustments to your treatment plan. Keep a log of your readings to share with your doctor during appointments.
• Be aware of the signs and symptoms of hypoglycemia (low blood sugar), such as shakiness, sweating, dizziness, and confusion. Carry a fast-acting source of glucose, like glucose tablets or juice, with you at all times in case your blood sugar drops too low. Inform your family and friends about how to help you if you experience a severe hypoglycemic episode.
• Follow a healthy diet and exercise regularly. GLUCRETA S 5/100MG TABLET 10'S is most effective when combined with lifestyle modifications. Focus on a balanced diet rich in fruits, vegetables, and whole grains, and aim for at least 30 minutes of moderate-intensity exercise most days of the week. Consult a registered dietitian or certified diabetes educator for personalized guidance.
• Stay hydrated by drinking plenty of water throughout the day. Adequate hydration supports overall health and can help regulate blood sugar levels.
• Pay attention to your feet and practice good foot care. People with diabetes are at higher risk of foot problems. Inspect your feet daily for any cuts, blisters, or sores, and wear comfortable, supportive shoes.
• If you experience any persistent or bothersome side effects, such as nausea, diarrhea, or skin rash, contact your doctor. They can help determine if the side effects are related to the medication and recommend appropriate management strategies.
• Store GLUCRETA S 5/100MG TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets.
• Attend all scheduled follow-up appointments with your doctor and other healthcare providers. Regular checkups are important for monitoring your overall health and ensuring that your diabetes management plan is effective.

• GLUCRETA S 5/100MG TABLET 10'S is generally safe to take with food. However, it is advisable to follow your doctor's instructions regarding diet while taking this medication. Consistent meal timings are recommended to maintain stable blood sugar levels.