ISTAVEL D 5/100MG TABLET 15'S

How ISTAVEL D 5/100MG TABLET 15'S Works

• ISTAVEL D 5/100MG TABLET 15'S is a combination medication containing sitagliptin and dapagliflozin, designed to manage blood sugar levels in adults with type 2 diabetes mellitus. This dual-action approach targets different pathways in the body to achieve better glycemic control than either medication could alone.
• Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones in the body. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), play a crucial role in regulating blood sugar levels. They stimulate insulin release from the pancreas when blood sugar is high and reduce glucagon secretion from the liver, which decreases glucose production. By inhibiting DPP-4, sitagliptin increases the levels of active incretin hormones in the body. This leads to increased insulin secretion and decreased glucagon secretion in a glucose-dependent manner. In simpler terms, sitagliptin helps your pancreas release more insulin when your blood sugar is high and reduces the amount of sugar your liver makes. This process is glucose-dependent, meaning it primarily works when your blood sugar is elevated, reducing the risk of hypoglycemia (low blood sugar).
• Dapagliflozin, on the other hand, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. SGLT2 is a protein found in the kidneys that is responsible for reabsorbing glucose back into the bloodstream. By inhibiting SGLT2, dapagliflozin reduces the reabsorption of glucose in the kidneys, causing excess glucose to be excreted in the urine. This lowers blood sugar levels independently of insulin. Dapagliflozin also offers other potential benefits, such as weight loss and blood pressure reduction, due to the loss of calories and fluid through the urine.
• When sitagliptin and dapagliflozin are combined in ISTAVEL D 5/100MG TABLET 15'S, they work synergistically to provide comprehensive blood sugar control. Sitagliptin enhances insulin secretion and reduces glucagon levels via the incretin pathway, while dapagliflozin removes excess glucose from the body through the urine. This combination addresses multiple aspects of type 2 diabetes, including insulin resistance, impaired insulin secretion, and increased glucose reabsorption. As a result, ISTAVEL D 5/100MG TABLET 15'S can effectively lower A1C levels (a measure of average blood sugar over 2-3 months) and improve overall glycemic control. Furthermore, because dapagliflozin works independently of insulin, the combination may also lower the risk of hypoglycemia compared to some other diabetes medications. Always use as directed by your healthcare provider.
• In summary, ISTAVEL D 5/100MG TABLET 15'S helps manage type 2 diabetes by increasing insulin release (sitagliptin) and removing excess sugar from the body through urine (dapagliflozin). This dual action helps to lower blood sugar levels effectively.

ISTAVEL D 5/100MG TABLET may cause side effects, although not everyone experiences them. Common side effects may include nausea, vomiting, diarrhea, constipation, abdominal pain, loss of appetite, headache, dizziness, and fatigue. Some patients may experience upper respiratory tract infection symptoms such as cough, sore throat, and runny nose. Less common but potentially serious side effects could involve allergic reactions (rash, itching, swelling), liver problems (yellowing of skin/eyes, dark urine), kidney problems (changes in urination), muscle pain or weakness, and changes in blood sugar levels. If you experience any severe or persistent side effects, discontinue use and consult your doctor immediately.

• If you miss a dose of ISTAVEL D 5/100MG TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep ISTAVEL D 5/100MG TAB 1X15 away from the reach of children and pets.
• Store ISTAVEL D 5/100MG TAB 1X15 at room temperature.

• Take ISTAVEL D 5/100MG TABLET 15'S as prescribed by your doctor. Do not alter the dosage or discontinue the medication without consulting them. This ensures optimal blood sugar control and minimizes the risk of potential side effects. Consistency is key to managing your diabetes effectively.
• It is recommended to take ISTAVEL D 5/100MG TABLET 15'S with food to minimize the risk of gastrointestinal discomfort. Taking it at the same time each day will also help you remember to take it consistently. This helps maintain steady blood sugar levels throughout the day.
• Follow a healthy diet and exercise regularly while taking ISTAVEL D 5/100MG TABLET 15'S. This medicine works best when combined with lifestyle modifications. A balanced diet, low in processed sugars and saturated fats, coupled with regular physical activity, significantly improves blood sugar control and overall well-being. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
• Monitor your blood sugar levels regularly as directed by your healthcare provider. Keeping a log of your blood sugar readings helps you and your doctor assess how well the medication is working and make any necessary adjustments to your treatment plan. Report any significant changes or concerns to your doctor promptly.
• Be aware of the symptoms of hypoglycemia (low blood sugar) such as sweating, shaking, rapid heartbeat, and confusion. Carry a source of fast-acting sugar with you, such as glucose tablets or fruit juice, in case you experience these symptoms. Knowing how to recognize and treat hypoglycemia is crucial for preventing serious complications. Consult your doctor or diabetes educator for guidance on managing low blood sugar levels.

• ISTAVEL D 5/100MG TABLET 15'S can be taken with or without food. However, it is important to take it consistently, either always with food or always without food, to maintain consistent absorption of the medication.
• Avoid excessive alcohol consumption while taking ISTAVEL D 5/100MG TABLET 15'S, as it may increase the risk of side effects.