ISTAMET XR 500MG TABLET 15'S

How ISTAMET XR 500MG TABLET 15'S Works

• ISTAMET XR 500MG TABLET 15'S is a combination medication designed to help manage blood sugar levels in individuals with type 2 diabetes. It combines two active ingredients: metformin and sitagliptin, each working through distinct mechanisms to improve glycemic control.
• Metformin, a biguanide, is the cornerstone of treatment for many with type 2 diabetes. It primarily works by reducing glucose production in the liver. The liver is a key player in maintaining blood sugar balance, and in individuals with diabetes, it often produces excessive glucose. Metformin helps to suppress this overproduction, preventing blood sugar levels from rising too high, especially after meals and during fasting periods. Additionally, metformin enhances insulin sensitivity in peripheral tissues, such as muscles. This means that the body's cells become more responsive to insulin, allowing them to utilize glucose more effectively. By improving insulin sensitivity, metformin helps lower blood sugar levels and promotes better glucose uptake by the cells. Furthermore, metformin slows down the absorption of glucose from the intestines, further contributing to its blood sugar-lowering effects. The extended-release (XR) formulation of ISTAMET ensures a gradual release of metformin, providing a more consistent effect throughout the day and minimizing potential gastrointestinal side effects.
• Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, functions by enhancing the body's natural ability to regulate blood sugar. DPP-4 is an enzyme that breaks down incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These incretin hormones play a crucial role in stimulating insulin release from the pancreas and suppressing glucagon secretion after meals. By inhibiting DPP-4, sitagliptin increases the levels of active incretin hormones in the body. This, in turn, leads to increased insulin secretion when blood sugar levels are high and decreased glucagon secretion, which reduces glucose production by the liver. The net effect is improved blood sugar control, particularly after meals. Sitagliptin's mechanism of action is glucose-dependent, meaning it primarily works when blood sugar levels are elevated, reducing the risk of hypoglycemia (low blood sugar).
• In summary, ISTAMET XR 500MG TABLET 15'S works through the combined actions of metformin and sitagliptin. Metformin reduces glucose production in the liver, enhances insulin sensitivity, and slows down glucose absorption. Sitagliptin increases incretin hormone levels, leading to increased insulin secretion and decreased glucagon secretion. Together, these mechanisms help to lower blood sugar levels and improve glycemic control in individuals with type 2 diabetes. This dual action helps to address multiple aspects of the disease, providing a comprehensive approach to managing blood sugar levels effectively. As always, this medication must be taken in conjunction with diet and exercise to achieve the best results. Consult your healthcare provider for personalized guidance.

ISTAMET XR 500MG TABLET 15'S can cause side effects, although not everyone experiences them. Common side effects may include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. Some individuals may experience metallic taste, heartburn, or constipation. Less common side effects include skin rashes, itching, and vitamin B12 deficiency. Serious but rare side effects include lactic acidosis (symptoms include rapid breathing, nausea, vomiting, and abdominal pain) and liver problems (symptoms include jaundice, dark urine, and fatigue). Allergic reactions (such as rash, itching, swelling, dizziness, and trouble breathing) are also possible. If you experience any severe or persistent side effects, stop taking ISTAMET XR 500MG TABLET 15'S and consult your doctor immediately.

• If you miss a dose of ISTAMET XR 500MG TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep ISTAMET XR 500MG TAB 1X15 away from the reach of children and pets.
• Store ISTAMET XR 500MG TAB 1X15 at room temperature.

• Take ISTAMET XR 500MG TABLET 15'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medicine without consulting your doctor, as this could affect your blood sugar control.
• ISTAMET XR 500MG TABLET 15'S should be taken with food to reduce the chance of stomach upset. Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a healthy lifestyle while taking ISTAMET XR 500MG TABLET 15'S. This includes following a balanced diet, engaging in regular physical activity, and maintaining a healthy weight. Consistent lifestyle choices can significantly improve blood sugar control and overall health.
• Regularly monitor your blood sugar levels as directed by your doctor, especially when you first start taking ISTAMET XR 500MG TABLET 15'S. Keeping track of your blood sugar readings helps you and your doctor determine how well the medication is working and whether any adjustments are needed. Share the readings with your doctor during your checkups.
• Be aware of the symptoms of low blood sugar (hypoglycemia), such as shakiness, sweating, confusion, dizziness, and rapid heartbeat. Keep a source of fast-acting sugar (like glucose tablets or fruit juice) with you at all times in case your blood sugar drops too low. Inform your family and friends about the symptoms of hypoglycemia and how to help you if you experience them.
• Stay hydrated by drinking plenty of water throughout the day while taking ISTAMET XR 500MG TABLET 15'S. Adequate hydration supports kidney function and overall health. Avoid excessive consumption of sugary drinks.
• Inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, before starting ISTAMET XR 500MG TABLET 15'S. Certain medications can interact with ISTAMET XR 500MG TABLET 15'S, affecting its effectiveness or increasing the risk of side effects. A complete medication list ensures safe and effective treatment.
• If you are scheduled for surgery or any medical procedure, inform your doctor that you are taking ISTAMET XR 500MG TABLET 15'S. Your doctor may need to adjust your medication or provide specific instructions before the procedure to ensure your safety.
• Store ISTAMET XR 500MG TABLET 15'S at room temperature, away from heat, moisture, and direct sunlight. Keep the medication in its original container and out of reach of children.
• Attend all scheduled appointments with your doctor and other healthcare providers while taking ISTAMET XR 500MG TABLET 15'S. Regular checkups and monitoring are essential for managing diabetes effectively and addressing any potential concerns.