LIPRIL AM TABLET 10'S

How LIPRIL AM TABLET 10'S Works

• LIPRIL AM Tablet 10's is a combination medication designed to manage hypertension (high blood pressure). It combines two active ingredients: Lisinopril and Amlodipine, each working through different mechanisms to effectively lower blood pressure.
• Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. ACE is an enzyme in the body that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, which increases blood pressure. Lisinopril inhibits ACE, thus reducing the production of angiotensin II. This leads to vasodilation (widening of blood vessels), reduced aldosterone secretion (aldosterone causes the kidneys to retain sodium and water, increasing blood volume), and ultimately, lowered blood pressure. By blocking the formation of angiotensin II, Lisinopril helps relax blood vessels and reduces the amount of water the body retains, both contributing to lower blood pressure and reduced strain on the heart.
• Amlodipine, on the other hand, is a calcium channel blocker. Calcium is essential for muscle contraction, including the muscles in the heart and blood vessel walls. Amlodipine works by blocking calcium from entering these muscle cells. This blockage relaxes and widens the blood vessels, making it easier for the heart to pump blood. Specifically, Amlodipine blocks calcium channels in the smooth muscle cells of the arteries. This reduces the contractility of these cells, leading to vasodilation. The reduced resistance in the blood vessels allows blood to flow more freely, reducing blood pressure. Amlodipine primarily affects the arteries and has less effect on the veins.
• In summary, LIPRIL AM Tablet 10's works through a dual mechanism. Lisinopril reduces the production of angiotensin II, a vasoconstrictor, leading to vasodilation and reduced water retention. Amlodipine blocks calcium channels in blood vessel walls, promoting vasodilation. The combined effect of these two medications results in a more effective reduction in blood pressure than either medication could achieve alone. This synergistic effect helps to control hypertension, reducing the risk of cardiovascular events such as stroke, heart attack, and kidney problems. The regular intake of this medicine as per the doctor's prescription is key to managing high blood pressure effectively.

Like all medicines, Lipril AM Tablet 10's can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Headache * Dizziness * Lightheadedness * Cough * Nausea * Diarrhea * Constipation * Fatigue * Weakness * Swelling of ankles or feet (edema) * Flushing (redness of the face) * Palpitations (feeling your heartbeat) **Uncommon side effects (may affect up to 1 in 100 people):** * Sleep disturbances * Mood changes (including anxiety) * Numbness or tingling * Vertigo (spinning sensation) * Tinnitus (ringing in the ears) * Low blood pressure * Rapid heartbeat * Chest pain * Shortness of breath * Vomiting * Abdominal pain * Indigestion * Dry mouth * Skin rash * Itching * Hair loss * Muscle cramps * Joint pain * Impotence * Increased sweating **Rare side effects (may affect up to 1 in 1,000 people):** * Confusion * Kidney problems **Very rare side effects (may affect up to 1 in 10,000 people):** * Severe allergic reaction (anaphylaxis) * Liver problems * Stevens-Johnson syndrome (severe skin rash with blistering) **Other possible side effects:** * Changes in blood test results * Depression * Tremor * Visual disturbances

• If you miss a dose of LIPRIL AM TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep LIPRIL AM TAB 1X10 away from the reach of children and pets.
• Store LIPRIL AM TAB 1X10 at room temperature.

• **Take LIPRIL AM TABLET 10'S as prescribed:** Always follow your doctor's instructions regarding dosage and timing. Do not alter the dose without consulting your healthcare provider. Consistency is key for optimal results in managing your blood pressure.
• **Monitor your blood pressure regularly:** Keep a log of your blood pressure readings at home and share it with your doctor. This helps in assessing how well the medication is working and if any adjustments are needed. Regular monitoring provides valuable data for personalized treatment.
• **Be mindful of potential side effects:** While LIPRIL AM TABLET 10'S is generally well-tolerated, be aware of possible side effects like dizziness, headache, or swelling. Report any persistent or bothersome side effects to your doctor promptly. Early reporting helps in managing and mitigating potential issues.
• **Maintain a healthy lifestyle:** Combine medication with lifestyle changes like a balanced diet, regular exercise, and stress management techniques. Reducing salt intake, avoiding processed foods, and engaging in physical activity can significantly improve blood pressure control. Healthy habits complement the medication's effects.
• **Avoid alcohol and smoking:** Alcohol and smoking can interfere with the effectiveness of LIPRIL AM TABLET 10'S and worsen hypertension. Limit alcohol consumption and quit smoking to enhance the medication's benefits and improve your overall cardiovascular health. These lifestyle modifications are crucial for long-term well-being.
• **Stay hydrated:** Drink plenty of water throughout the day. Adequate hydration supports healthy blood circulation and can help manage blood pressure levels effectively. Water plays a vital role in maintaining overall cardiovascular function.
• **Inform your doctor about other medications:** Before starting LIPRIL AM TABLET 10'S, inform your doctor about all other medications, supplements, and herbal remedies you are taking. This helps prevent potential drug interactions and ensures the safe and effective use of LIPRIL AM TABLET 10'S. Transparency is crucial for preventing adverse effects.

• LIPRIL AM TABLET 10'S is generally taken without regard to food. However, it is important to maintain a consistent diet while taking this medication. Avoid consuming large amounts of grapefruit or grapefruit juice, as it may increase the blood levels of amlodipine, one of the active ingredients in LIPRIL AM TABLET 10'S, potentially leading to increased side effects. Always follow your doctor's specific instructions regarding diet.