NEBIZAR AM TABLET 10'S

How NEBIZAR AM TABLET 10'S Works

• NEBIZAR AM TABLET 10'S is a combination medication containing Nebivolol and Amlodipine, designed to manage hypertension (high blood pressure). It works through complementary mechanisms to effectively lower blood pressure and reduce the risk of cardiovascular events.
• Nebivolol, a beta-blocker, primarily works by selectively blocking beta-1 adrenergic receptors in the heart. This action reduces heart rate and the force of heart muscle contraction, leading to a decrease in cardiac output. Additionally, Nebivolol stimulates the release of nitric oxide (NO) from endothelial cells lining the blood vessels. Nitric oxide is a potent vasodilator, meaning it widens blood vessels. This vasodilation reduces peripheral vascular resistance, further contributing to lower blood pressure. The dual action of reducing cardiac output and peripheral resistance makes Nebivolol an effective antihypertensive agent. It also improves blood flow to various tissues and organs.
• Amlodipine, a calcium channel blocker, operates differently. It inhibits the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. By blocking calcium channels in vascular smooth muscle, Amlodipine causes these muscles to relax, leading to vasodilation, especially in the arterioles. This vasodilation reduces peripheral resistance and lowers blood pressure. Unlike some other calcium channel blockers, Amlodipine has a greater effect on vascular smooth muscle than on cardiac muscle, minimizing its impact on heart rate. This makes it suitable for patients who may not tolerate significant reductions in heart rate. Amlodipine's action also helps to reduce the workload on the heart, decreasing the heart's oxygen demand.
• The combination of Nebivolol and Amlodipine in NEBIZAR AM TABLET 10'S provides a synergistic effect. Nebivolol reduces cardiac output and promotes vasodilation through nitric oxide, while Amlodipine directly relaxes vascular smooth muscle. This dual mechanism ensures a more comprehensive and effective reduction in blood pressure compared to using either drug alone. The combination is particularly useful for patients who require multiple mechanisms to control their hypertension. By addressing both cardiac output and peripheral resistance, NEBIZAR AM TABLET 10'S helps to maintain healthy blood pressure levels, reducing the strain on the cardiovascular system and lowering the risk of associated complications such as stroke, heart attack, and kidney disease.
• In summary, NEBIZAR AM TABLET 10'S works by combining the beta-blocking and nitric oxide-releasing effects of Nebivolol with the calcium channel blocking effects of Amlodipine. This comprehensive approach effectively lowers blood pressure by reducing cardiac output, relaxing blood vessels, and decreasing peripheral resistance, ultimately protecting the cardiovascular system and improving overall health.

The most common side effects of Nebizar AM Tablet are headache, flushing (sense of warmth in the face, ears, neck, and trunk), palpitations, increased heart rate, ankle swelling, fatigue, and nausea. Other possible side effects include: * Dizziness * Lightheadedness * Sleepiness * Abdominal pain * Constipation * Diarrhea * Dyspepsia (indigestion) * Shortness of breath * Muscle cramps * Visual disturbances * Hypotension (low blood pressure) * Cold extremities * Peripheral edema * Bradycardia (slow heart rate) * AV block (heart conduction problem) * Exacerbation of intermittent claudication (increased leg pain during exercise) * Raynaud's phenomenon (reduced blood flow to extremities) * Nightmares * Depression * Impotence * Dry mouth * Skin rash or itching * Worsening of psoriasis * Hair loss * Confusion * Hallucinations * Psychoses * Thrombocytopenia (low platelet count) * Agranulocytosis (low white blood cell count) * Increased liver enzymes * Allergic reactions (rash, itching, swelling) This is not an exhaustive list, and other side effects may occur. If you experience any unusual symptoms while taking Nebizar AM Tablet, consult your doctor.

• If you miss a dose of NEBIZAR AM TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep NEBIZAR AM 5/5MG TAB 1X10 away from the reach of children and pets.
• Store NEBIZAR AM 5/5MG TAB 1X10 at room temperature.

• NEBIZAR AM TABLET 10'S may be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent levels of medication in your body. Avoid consuming grapefruit or grapefruit juice while taking this medicine, as it can increase the concentration of amlodipine in your blood, potentially leading to increased side effects.