PLAGERINE A 150 CAPSULE 10'S

How PLAGERINE A 150 CAPSULE 10'S Works

• PLAGERINE A 150 CAPSULE 10'S is a dual antiplatelet medication combining Aspirin and Clopidogrel, working synergistically to prevent blood clot formation. This combination is particularly effective in individuals at high risk of thromboembolic events, such as those with a history of heart attack, stroke, or peripheral artery disease.
• Aspirin, also known as acetylsalicylic acid, inhibits the production of thromboxane A2, a substance that causes platelets to aggregate and form clots. It achieves this by irreversibly acetylating cyclooxygenase-1 (COX-1), an enzyme crucial for thromboxane A2 synthesis. By blocking COX-1, Aspirin effectively reduces platelet aggregation throughout its lifespan (approximately 7-10 days). This action is crucial in preventing arterial thrombosis, where clots can obstruct blood flow to vital organs.
• Clopidogrel, on the other hand, is a thienopyridine derivative that inhibits platelet aggregation through a different mechanism. It is a prodrug, meaning it requires metabolic activation in the liver to become an active metabolite. This active metabolite selectively and irreversibly inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor. ADP is a key mediator of platelet activation and aggregation. By blocking ADP binding, Clopidogrel prevents the activation of the glycoprotein IIb/IIIa complex, which is essential for platelets to bind to fibrinogen and each other, thus halting clot formation.
• The combined action of Aspirin and Clopidogrel provides a more potent antiplatelet effect than either drug alone. Aspirin quickly inhibits thromboxane A2 production, while Clopidogrel blocks ADP-mediated platelet activation. This dual inhibition significantly reduces the risk of arterial thrombosis, preventing adverse cardiovascular events. The synergistic effect targets multiple pathways of platelet activation, providing a comprehensive approach to preventing blood clots.
• This medication is often prescribed following percutaneous coronary intervention (PCI), such as stent placement, to prevent stent thrombosis. It is also used in patients with acute coronary syndrome (ACS), including unstable angina and myocardial infarction, to reduce the risk of further cardiovascular events. Long-term use should be under medical supervision due to the increased risk of bleeding. Patients should be educated on recognizing signs of bleeding and reporting them to their healthcare provider.

Common side effects of Plagerine A 150 Capsule may include: Increased bleeding risk, heartburn, indigestion, stomach pain, diarrhea, nausea, vomiting, headache, dizziness, fatigue, rash, itching. Less common but potentially serious side effects include: Severe allergic reactions (hives, swelling, difficulty breathing), liver problems (yellowing of skin/eyes, dark urine), kidney problems (changes in urination), blood disorders (unexplained bruising/bleeding, fever, sore throat), TTP (thrombotic thrombocytopenic purpura - a rare blood clotting disorder), and stroke. Consult your doctor immediately if you experience any severe or persistent side effects.

• If you miss a dose of Plagerine A 150 Capsule, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep PLAGERINE A 150MG CAP 1X10 away from the reach of children and pets.
• Store PLAGERINE A 150MG CAP 1X10 at room temperature.

• Take PLAGERINE A 150 CAPSULE 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. This ensures optimal effectiveness and minimizes potential side effects. Consistency is key for best results.
• Swallow the PLAGERINE A 150 CAPSULE 10'S whole with a glass of water. Do not crush, chew, or break the capsule, as this can affect how the medication is absorbed in your body. Proper administration helps maintain the integrity of the drug's delivery system.
• If you miss a dose of PLAGERINE A 150 CAPSULE 10'S, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up, as this can increase the risk of adverse effects. Managing missed doses correctly is important for a consistent therapeutic effect.
• Inform your doctor about all other medications, supplements, and herbal products you are currently taking before starting PLAGERINE A 150 CAPSULE 10'S. This helps prevent potential drug interactions, which can either reduce the effectiveness of PLAGERINE A 150 CAPSULE 10'S or increase the risk of side effects. Transparency with your healthcare provider ensures your safety.
• Store PLAGERINE A 150 CAPSULE 10'S in a cool, dry place, away from direct sunlight and moisture. Keep it out of reach of children and pets. Proper storage helps maintain the medication's potency and prevents accidental ingestion. Check the expiration date regularly and dispose of any expired medication properly.

• Plagerine A 150 Capsule can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent drug levels in the body.