TELPLUS TRIO TABLET 10'S

How TELPLUS TRIO TABLET 10'S Works

• TELPLUS TRIO TABLET 10'S is a combination medication designed to manage hypertension (high blood pressure) effectively. It combines the actions of three active ingredients: telmisartan, amlodipine, and hydrochlorothiazide. Each component works through a distinct mechanism to lower blood pressure, providing a synergistic effect greater than any single agent could achieve alone.
• Telmisartan, an angiotensin II receptor blocker (ARB), selectively blocks the binding of angiotensin II to the AT1 receptors found in various tissues, including the heart, blood vessels, kidneys, and adrenal glands. Angiotensin II is a potent vasoconstrictor that also stimulates the release of aldosterone, a hormone that promotes sodium and water retention. By blocking angiotensin II, telmisartan causes blood vessels to relax and widen, reducing peripheral resistance and lowering blood pressure. Additionally, it reduces the release of aldosterone, leading to decreased sodium and water retention, further contributing to blood pressure reduction. Telmisartan's action is long-lasting, providing sustained blood pressure control throughout the day.
• Amlodipine, a calcium channel blocker (CCB), primarily works by inhibiting the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. By blocking calcium channels in vascular smooth muscle, amlodipine causes the arteries to relax and dilate. This vasodilation reduces peripheral vascular resistance, which subsequently lowers blood pressure. In the heart, amlodipine reduces the force of contraction, known as the negative inotropic effect, and slows down the heart rate to some extent, known as the negative chronotropic effect. These combined effects reduce the workload on the heart and further contribute to lowering blood pressure. Amlodipine is particularly effective in treating systolic hypertension and is known for its long duration of action, allowing for once-daily dosing.
• Hydrochlorothiazide (HCTZ) is a thiazide diuretic that works primarily in the kidneys to promote the excretion of sodium and water. It inhibits the sodium-chloride symporter in the distal convoluted tubule of the nephron, leading to increased sodium and chloride excretion. As sodium is excreted, water follows, resulting in a decrease in blood volume. This reduction in blood volume lowers cardiac output and subsequently reduces blood pressure. Over time, HCTZ also causes vasodilation, further contributing to its antihypertensive effects. HCTZ is particularly effective in reducing systolic blood pressure and is often used in combination with other antihypertensive agents to achieve optimal blood pressure control. The diuretic effect of HCTZ also helps to alleviate edema, which can be beneficial for patients with heart failure or other conditions associated with fluid retention.
• In summary, TELPLUS TRIO TABLET 10'S lowers blood pressure through the combined actions of telmisartan (ARB), amlodipine (CCB), and hydrochlorothiazide (thiazide diuretic). Telmisartan relaxes blood vessels and reduces sodium and water retention by blocking angiotensin II. Amlodipine dilates arteries and reduces the workload on the heart by blocking calcium channels. Hydrochlorothiazide promotes sodium and water excretion, reducing blood volume. Together, these three mechanisms provide comprehensive blood pressure control, reducing the risk of cardiovascular events such as heart attack, stroke, and kidney disease. This triple combination approach allows for effective management of hypertension, especially in patients who require multiple medications to achieve their target blood pressure goals.

The following side effects may occur while taking Telplus Trio Tablet: * Dizziness * Headache * Fatigue * Nausea * Vomiting * Diarrhea * Abdominal pain * Cough * Muscle cramps * Increased potassium levels in blood * Slow heart rate * Low blood pressure * Changes in blood sugar levels * Allergic reactions (rash, itching, swelling) * Sleep disturbances * Increased uric acid in blood * Visual disturbances * Orthostatic hypotension (dizziness upon standing) * Electrolyte imbalance * Impotence This is not an exhaustive list. Consult your doctor if you experience any unusual or persistent side effects.

• If you miss a dose of TELPLUS TRIO TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep TELPLUS TRIO TAB 1X10 away from the reach of children and pets.
• Store TELPLUS TRIO TAB 1X10 at room temperature.

• Take TELPLUS TRIO TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or stop taking the medication without consulting them, as this could lead to uncontrolled blood pressure and potential health complications. Consistent adherence to your doctor's instructions is crucial for effective management of hypertension.
• Monitor your blood pressure regularly at home using a validated blood pressure monitor. Keep a record of your readings and share them with your doctor during follow-up appointments. This will help your doctor assess the effectiveness of the medication and make any necessary adjustments to your treatment plan.
• TELPLUS TRIO TABLET 10'S may cause dizziness, especially when you first start taking it or when the dosage is increased. To minimize this, rise slowly from a sitting or lying position. Avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you. If dizziness persists or becomes severe, consult your doctor.
• Inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, before starting TELPLUS TRIO TABLET 10'S. Certain medications can interact with TELPLUS TRIO TABLET 10'S, potentially affecting its efficacy or increasing the risk of side effects. A complete medication list will help your doctor make informed decisions about your treatment.
• Adopt a healthy lifestyle to complement the effects of TELPLUS TRIO TABLET 10'S. This includes following a balanced diet low in sodium and saturated fats, engaging in regular physical activity (at least 30 minutes most days of the week), maintaining a healthy weight, limiting alcohol consumption, and quitting smoking. These lifestyle modifications can significantly improve blood pressure control and overall cardiovascular health. Stay hydrated by drinking plenty of water throughout the day. Adequate hydration helps maintain blood volume and supports healthy kidney function, both of which are important for blood pressure regulation.

• TELPLUS TRIO TABLET 10'S can be taken with or without food. However, it is important to take it at the same time each day to maintain consistent blood levels of the medication.
• Avoid consuming large amounts of grapefruit or grapefruit juice while taking TELPLUS TRIO TABLET 10'S, as it may increase the levels of amlodipine in your blood, potentially leading to increased side effects.