SIAGLIDE M 50/1000MG TABLET 15'S

How SIAGLIDE M 50/1000MG TABLET 15'S Works

• SIAGLIDE M 50/1000MG TABLET is a combination medication containing Sitagliptin and Metformin, designed to manage type 2 diabetes mellitus effectively. It works through complementary mechanisms to control blood sugar levels.
• Sitagliptin belongs to a class of drugs called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). DPP-4 inhibitors work by increasing the amount of incretin hormones released in the body. Incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), are naturally produced in the intestine in response to food intake. These hormones stimulate insulin release from the pancreas and decrease glucagon secretion from the liver, both of which help to lower blood glucose levels. Sitagliptin inhibits the DPP-4 enzyme, which normally breaks down incretin hormones. By inhibiting DPP-4, Sitagliptin prolongs the action of incretin hormones, resulting in increased insulin secretion and decreased glucagon secretion in a glucose-dependent manner. This means that its effect is more pronounced when blood glucose levels are high and less so when blood glucose levels are normal, reducing the risk of hypoglycemia.
• Metformin, on the other hand, is a biguanide that works primarily by reducing glucose production in the liver. The liver is a major source of glucose in the body, and in people with type 2 diabetes, the liver often produces too much glucose. Metformin decreases hepatic glucose production by inhibiting gluconeogenesis (the formation of glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Additionally, Metformin improves insulin sensitivity in peripheral tissues, such as muscle and fat, allowing cells to utilize glucose more effectively. This enhanced glucose uptake helps to lower blood glucose levels. Unlike some other diabetes medications, Metformin does not stimulate insulin secretion, which minimizes the risk of hypoglycemia. It also has a modest effect on reducing triglyceride levels and may promote weight loss in some individuals.
• The combination of Sitagliptin and Metformin in SIAGLIDE M provides a dual approach to managing blood sugar. Sitagliptin enhances insulin secretion and reduces glucagon secretion in a glucose-dependent manner, while Metformin reduces glucose production in the liver and improves insulin sensitivity. This synergistic effect results in better glycemic control compared to using either medication alone. This combination helps in managing post-meal glucose spikes as well as fasting blood glucose levels, contributing to an overall improvement in HbA1c levels (a measure of long-term blood glucose control).
• By working together, Sitagliptin and Metformin help to restore the body’s natural ability to regulate blood sugar levels, leading to improved metabolic control and reduced risk of diabetes-related complications. However, it is important to note that SIAGLIDE M should be used in conjunction with lifestyle modifications, such as diet and exercise, to achieve optimal blood glucose control.

Possible side effects of SIAGLIDE M 50/1000MG TABLET may include: * **Common:** Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache. * **Uncommon:** Hypoglycemia (low blood sugar), skin rash, itching, allergic reactions, dizziness. * **Rare:** Lactic acidosis (serious metabolic problem), liver problems, vitamin B12 deficiency, joint pain, muscle pain.

• If you miss a dose of SIAGLIDE M 50/1000MG TABLET, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep SIAGLIDE M 50/1000MG TAB 1X15 away from the reach of children and pets.
• Store SIAGLIDE M 50/1000MG TAB 1X15 at room temperature.

• Take SIAGLIDE M 50/1000MG TABLET 15'S as prescribed by your doctor, usually once or twice daily with meals, to help manage your blood sugar levels effectively. Consistency is key for optimal results.
• To minimize potential stomach upset, always take SIAGLIDE M 50/1000MG TABLET 15'S with food. This also helps improve the absorption of the medication, leading to better blood sugar control.
• It's important to follow a balanced diet and exercise regularly while taking SIAGLIDE M 50/1000MG TABLET 15'S. This medication works best when combined with healthy lifestyle choices, significantly improving your overall diabetes management.
• Regularly monitor your blood sugar levels as directed by your healthcare provider while on SIAGLIDE M 50/1000MG TABLET 15'S. This helps you and your doctor understand how well the medication is working and make any necessary adjustments to your treatment plan.
• Stay hydrated by drinking plenty of water throughout the day while taking SIAGLIDE M 50/1000MG TABLET 15'S. Adequate hydration supports kidney function, which is important as this medication can affect kidney function in some individuals. Also, be aware of the symptoms of low blood sugar (hypoglycemia) such as sweating, shaking, and confusion, and know how to treat it promptly. Always carry a source of fast-acting sugar with you.
• Inform your doctor about all other medications, supplements, and herbal remedies you are taking before starting SIAGLIDE M 50/1000MG TABLET 15'S, as they may interact with this medication and affect its effectiveness or safety. Certain medications can either increase or decrease the blood sugar lowering effect of SIAGLIDE M.
• Do not abruptly stop taking SIAGLIDE M 50/1000MG TABLET 15'S without consulting your doctor. Sudden discontinuation can lead to a rapid increase in blood sugar levels. Your doctor will advise you on the proper way to discontinue the medication if it's necessary.
• Be cautious while driving or operating machinery when you first start taking SIAGLIDE M 50/1000MG TABLET 15'S, as it may cause dizziness or low blood sugar in some individuals. Ensure you know how the medication affects you before engaging in activities that require alertness. If you experience dizziness or blurred vision, avoid driving or operating machinery.
• If you are scheduled for any surgery or medical procedure, inform your doctor that you are taking SIAGLIDE M 50/1000MG TABLET 15'S. Your doctor may advise you to temporarily discontinue the medication before the procedure to prevent any complications related to blood sugar control.
• Attend all scheduled follow-up appointments with your doctor and undergo regular check-ups while taking SIAGLIDE M 50/1000MG TABLET 15'S. These appointments are crucial for monitoring your overall health and ensuring that your diabetes management plan is effective. Discuss any concerns or side effects you may be experiencing with your doctor during these appointments.

• SIAGLIDE M 50/1000MG TABLET 15'S should be taken with food to help prevent stomach upset. It is best to take it at the same time each day to maintain a consistent level of medication in your body. Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of side effects like hypoglycemia (low blood sugar).