VALPROL CR 500MG TABLET 15'S

How VALPROL CR 500MG TABLET 15'S Works

• VALPROL CR 500MG TABLET 15'S contains valproic acid as its active ingredient. Valproic acid is a broad-spectrum anticonvulsant and mood-stabilizing medication that works through several mechanisms of action in the brain to control seizures and stabilize mood. One primary way valproic acid works is by increasing the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter, meaning it helps to reduce the excitability of neurons. By increasing GABA levels, valproic acid helps to calm overactive nerve cells, reducing the likelihood of seizures. This is achieved by inhibiting enzymes that break down GABA and by enhancing GABA's synthesis.
• Additionally, valproic acid affects sodium channels in the brain. It blocks the repetitive firing of neurons by prolonging the inactivated state of voltage-gated sodium channels. This means that after a neuron fires, it takes longer for it to be able to fire again. This stabilization of neuronal firing patterns helps to prevent the rapid and uncontrolled electrical activity that characterizes seizures. By modulating sodium channel activity, valproic acid contributes to the overall reduction of seizure frequency and severity.
• Furthermore, valproic acid also influences calcium channels. It can block T-type calcium channels, which are involved in the generation of certain types of seizures, particularly absence seizures. By blocking these channels, valproic acid can help to prevent the rhythmic, spike-and-wave discharges in the brain that are characteristic of absence seizures. This multi-faceted approach—enhancing GABA activity, stabilizing sodium channels, and modulating calcium channels—makes valproic acid effective in treating a variety of seizure disorders as well as bipolar disorder, where it helps to stabilize mood swings.
• The 'CR' in VALPROL CR 500MG TABLET 15'S stands for controlled-release. This formulation is designed to release the valproic acid slowly and steadily into the body over an extended period. This controlled release helps to maintain a more stable level of the medication in the bloodstream, which can reduce the frequency of side effects and improve the medication's effectiveness throughout the day. Consistent blood levels are particularly important in managing epilepsy to prevent breakthrough seizures. The slow-release mechanism allows for once- or twice-daily dosing, improving patient compliance and convenience.

Common side effects of VALPROL CR 500MG TABLET may include nausea, vomiting, diarrhea, stomach pain, loss of appetite, headache, dizziness, drowsiness, blurred vision, double vision, hair loss, weight gain, tremor, difficulty sleeping (insomnia), nervousness, abnormal thinking, memory problems, aggression, ataxia (loss of coordination), and changes in menstruation. Less common but potentially serious side effects include liver problems, pancreatitis, decreased blood platelets (thrombocytopenia), increased ammonia levels in the blood (hyperammonemia), and severe skin reactions. Allergic reactions are also possible. Contact your doctor immediately if you experience any signs of liver damage (such as jaundice, dark urine, or fatigue), pancreatitis (severe abdominal pain), unusual bleeding or bruising, or a severe rash.

• If you miss a dose of VALPROL CR 500MG TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep VALPROL CR 500MG TAB 1X15 away from the reach of children and pets.
• Store VALPROL CR 500MG TAB 1X15 at room temperature.

• **Take Valprol CR 500mg Tablet as Prescribed:** Always adhere to your doctor's instructions regarding dosage and timing. Do not alter the dosage without consulting your healthcare provider, even if you feel better or worse. Consistency is key for optimal seizure control and mood stabilization.
• **Administer with Food:** To minimize stomach upset, take Valprol CR 500mg Tablet with food. Food helps to slow down the absorption rate, which can reduce the likelihood of gastrointestinal side effects such as nausea, vomiting, or stomach cramps. This also aids in maintaining more stable blood levels of the medication throughout the day.
• **Monitor for Side Effects:** Be vigilant for potential side effects and report them promptly to your doctor. Common side effects include drowsiness, dizziness, headache, weight gain, hair loss, and tremor. Rare but serious side effects can include liver problems, pancreatitis, and changes in mood or behavior. Regular monitoring can help manage or mitigate these effects.
• **Avoid Alcohol:** Alcohol can interact with Valprol CR 500mg Tablet, increasing drowsiness and potentially worsening side effects. It can also interfere with the effectiveness of the medication in controlling seizures or stabilizing mood. Therefore, it is crucial to avoid alcohol consumption while taking this medication.
• **Maintain Consistent Sleep Schedule:** Adequate and regular sleep is essential when taking Valprol CR 500mg Tablet, especially for seizure control and mood stabilization. Lack of sleep can trigger seizures and exacerbate mood swings. Aim for a consistent sleep schedule to support the medication's effectiveness and your overall well-being.

• VALPROL CR 500MG TABLET 15'S can be taken with or without food, but it is recommended to take it consistently with or without food to maintain stable blood levels of the medication.
• Taking it with food may help reduce stomach upset.