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Composition
Content Reviewed By:
Dr. Anil Gupta
, (MBBS)
Written By:
Mr. Ankit Jain
, (B.Pharm)
Most side effects are temporary and resolve as your body adapts to the medication. If any side effects persist or cause concern, it's important to consult your doctor.

Concomitant Medicines and Drug Interactions
Important interaction warningsAngispan TR 6.5 must never be used together with phosphodiesterase‑5 inhibitors such as sildenafil, tadalafil, or vardenafil, or with soluble guanylate cyclase stimulators, due to the risk of severe, potentially life‑threatening hypotension.
No, you should not take sildenafil if you are taking ANGISPAN TR 6.5MG CAPSULE 30'S. Taking these two medicines together can cause an excessive fall in blood pressure, which may even be life-threatening.
ANGISPAN TR 6.5MG CAPSULE 30'S decreases the blood pressure by relaxing the blood vessels, but is not recommended for the treatment of high blood pressure. The drop in blood pressure may cause lightheadedness, especially when changing your position suddenly.
Yes, excessive use of ANGISPAN TR 6.5MG CAPSULE 30'S may cause tolerance which means that ANGISPAN TR 6.5MG CAPSULE 30'S may lose its effectiveness on you. Therefore, usually the doctors prescribe the smallest dose required for effective relief of acute angina attack. This helps maintain the effectiveness of ANGISPAN TR 6.5MG CAPSULE 30'S.
Excess ANGISPAN TR 6.5MG CAPSULE 30'S may result in low blood pressure, sweating, nausea, vomiting, headache, weak and fast pulse. It may also cause weakness, lightheadedness on standing and the patient might even faint. The patient will require emergency medical treatment in such a case.
Stopping ANGISPAN TR 6.5MG CAPSULE 30'S suddenly may bring on attacks of angina, especially if you have been using it for several weeks or more. Talk to your doctor who will advise you to reduce the dose gradually over 4 to 6 weeks before you stop using it completely.
ANGISPAN TR 6.5MG CAPSULE 30'S is prescribed to prevent attacks of heart-related chest pain (angina) in patients with coronary artery disease. In this disease the blood vessels (coronary arteries) which supply blood to the heart become narrowed because of which the heart has to work harder to get enough oxygen. ANGISPAN TR 6.5MG CAPSULE 30'S prevents angina by relaxing the blood vessels so that the heart does not have to work very hard. Also, relaxation of coronary arteries increases the oxygen supply to the heart.
Angispan TR 6.5 is used for the prevention of angina pectoris (chest pain) due to coronary artery disease. It contains sustained release nitroglycerin, which helps reduce the frequency and severity of angina episodes by dilating blood vessels and improving blood flow to the heart muscle. It is not intended for immediate relief of an acute angina attack.
Angispan TR 6.5 contains nitroglycerin, an organic nitrate that is converted in the body to nitric oxide. Nitric oxide relaxes smooth muscle in blood vessel walls, causing vasodilation. This reduces venous return to the heart (preload) and lowers systemic vascular resistance (afterload), thereby decreasing the heart’s workload and oxygen demand. Improved coronary blood flow also helps relieve ischemia and angina symptoms.
No. Angispan TR 6.5 is a sustained release preparation and is not suitable for rapid relief of acute chest pain. For sudden angina attacks, fast‑acting nitroglycerin formulations such as sublingual tablets or sprays are typically used as prescribed by a doctor. Patients should follow their individualized angina action plan and seek emergency care if chest pain is severe, prolonged, or atypical.
Angispan TR 6.5 should be taken exactly as prescribed by your physician. The capsule should be swallowed whole with water and must not be crushed, chewed, or opened, as this can disrupt the sustained release mechanism. It is usually taken at specific times each day to maintain consistent blood levels. Do not change the timing or frequency without consulting your doctor.
Common side effects include headache, flushing, dizziness, light‑headedness, a feeling of warmth, and sometimes nausea. These effects are often more noticeable when treatment is started or the dose is adjusted and may lessen as your body adapts. If headaches are severe, dizziness leads to fainting, or you notice very low blood pressure symptoms, contact your doctor promptly.
Angispan TR 6.5 is contraindicated in people with severe hypotension, shock, marked anemia, increased intracranial pressure, or known hypersensitivity to nitroglycerin or other nitrates. It must not be used in patients taking phosphodiesterase‑5 inhibitors (such as sildenafil, tadalafil, or vardenafil) or soluble guanylate cyclase stimulators because of the risk of profound hypotension. Suitability must always be assessed by a physician.
Alcohol can enhance the blood pressure‑lowering effect of nitroglycerin and increase the risk of dizziness, fainting, or falls. It is generally advisable to avoid or strictly limit alcohol intake while taking Angispan TR 6.5. Discuss your alcohol consumption with your doctor so that individualized advice can be provided based on your cardiovascular status and other medications.
Data on the use of sustained release nitroglycerin in pregnancy are limited. Angispan TR 6.5 should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus, and strictly under specialist supervision. Pregnant women with angina or coronary disease should be managed by a cardiologist and obstetrician together, and self‑medication should be avoided.
You should not stop Angispan TR 6.5 on your own, even if your symptoms improve. Abrupt discontinuation after prolonged use may lead to rebound angina or worsening ischemia. Any change in dose or discontinuation should be done gradually and only under medical supervision, with appropriate adjustment of your overall anti‑anginal regimen.
Yes. Angispan TR 6.5 can interact with several cardiovascular drugs. Concomitant use with phosphodiesterase‑5 inhibitors is contraindicated due to the risk of severe hypotension. Caution is required when it is combined with other blood pressure‑lowering agents such as beta‑blockers, calcium channel blockers, ACE inhibitors, diuretics, or other vasodilators, as additive hypotensive effects may occur. Always inform your doctor and pharmacist about all medicines you are taking.
If you miss a dose, take it as soon as you remember unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of low blood pressure, dizziness, or fainting. If you frequently forget doses, discuss adherence strategies with your healthcare provider.
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MRP
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