augmentin 1.2gm injection
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AUGMENTIN 1.2GM INJECTION

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AUGMENTIN 1.2GM INJECTION

By GSK (GLAXO SMITHKLINE) PHARMACEUTICALS LIMITED

MRP

157.52

₹127

19.38 % OFF

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Product DetailsArrow

Content Reviewed By:

Dr. Anil Gupta

, (MBBS)

Written By:

Mr. Ankit Jain

, (B.Pharm)

About AUGMENTIN 1.2GM INJECTION

  • Inj Augmentin is an injectable antibiotic formulation that contains amoxicillin (a broad‑spectrum penicillin) and clavulanic acid (a beta‑lactamase inhibitor). It is used for the treatment of a wide range of bacterial infections caused by organisms that are susceptible to this combination, particularly when resistance to amoxicillin alone is suspected or documented. Typical indications include infections of the lower and upper respiratory tract (such as pneumonia, bronchitis, and sinusitis), complicated urinary tract infections, intra‑abdominal infections, skin and soft tissue infections, bone and joint infections, and certain gynecological and postoperative infections. The injection is generally reserved for moderate to severe infections, for patients who cannot take oral medication, or when rapid high blood levels of the antibiotic are desired. Amoxicillin works by inhibiting bacterial cell wall synthesis, leading to weakening and death of susceptible bacteria. Some bacteria produce enzymes called beta‑lactamases that can inactivate amoxicillin. Clavulanic acid blocks many of these enzymes, thereby restoring and extending the activity of amoxicillin against beta‑lactamase‑producing strains. This combination is active against a variety of Gram‑positive and Gram‑negative organisms, including many strains of Streptococcus, Staphylococcus (non‑methicillin‑resistant), Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Klebsiella, and some anaerobes, depending on local resistance patterns. Inj Augmentin is administered by a healthcare professional, usually by slow intravenous injection or intravenous infusion. The choice of dose, dosing interval, and duration of therapy must be individualized by the treating physician based on the type and severity of infection, the suspected or confirmed pathogen, the patient’s age and body weight, and kidney and liver function. In severe infections, it may be started intravenously and later switched to an appropriate oral formulation once the patient improves and can tolerate oral therapy. It is important that the full prescribed course is completed, even if symptoms improve earlier, to reduce the risk of treatment failure and development of antibiotic resistance. Common adverse effects include diarrhea, nausea, vomiting, and mild skin rash. Because this medicine can disturb normal gut flora, there is a risk of antibiotic‑associated colitis, including Clostridioides difficile‑associated diarrhea, particularly with prolonged use or in high‑risk patients. Hypersensitivity reactions ranging from mild rash to severe anaphylaxis can occur, especially in individuals with a history of allergy to penicillins or other beta‑lactam antibiotics. Liver‑related side effects such as elevations in liver enzymes, cholestatic jaundice, or hepatitis have been reported, more often in older adults or with prolonged therapy. Blood count changes (such as leukopenia, thrombocytopenia, or hemolytic anemia) and seizures have been reported rarely, usually in patients with underlying risk factors. Before starting Inj Augmentin, the healthcare provider should review the patient’s history of drug allergies, previous antibiotic reactions, liver and kidney disease, and concurrent medications. Dose adjustments or extended dosing intervals are often required in patients with impaired renal function. Monitoring of liver function tests, renal function, and complete blood counts may be appropriate during prolonged courses or in patients with pre‑existing organ dysfunction. This medicine is not effective against viral infections such as the common cold or influenza and should not be used for non‑bacterial illnesses. Use should always follow a clinician’s assessment and, where possible, be guided by culture and sensitivity results and local antimicrobial stewardship recommendations.

Uses of AUGMENTIN 1.2GM INJECTION

  • Infections of the sinuses and the middle ear.
  • Infections affecting the respiratory tract.
  • Urinary tract infections (UTIs) are also treated with AUGMENTIN 1.2GM INJECTION.
  • Skin and soft tissue infections, encompassing also dental infections.
  • Infections located in bones and joints.

Side Effects of AUGMENTIN 1.2GM INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious side effects include allergic reactions such as skin rash and blood vessel inflammation (red or purple spots), hyperactivity, and a decrease in white blood cell count. Common side effects include fever, joint pain, swelling in the neck, groin, or armpit, angioedema (swelling of the face or throat), difficulty in breathing, and diarrhea.

  • Allergic reactions such as skin rash and blood vessel inflammation (red or purple spots)
  • Hyperactivity
  • Decrease in white blood cell count
  • Fever
  • Joint pain
  • Swelling in the neck, groin, or armpit
  • Angioedema (swelling of face or throat)
  • Difficulty in breathing
  • Diarrhea

Safety Advice for AUGMENTIN 1.2GM INJECTIONArrow

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Gastrointestinal and Clostridioides difficile risk

Monitor for severe diarrhea

Like other broad‑spectrum antibiotics, Inj Augmentin can disrupt normal intestinal flora and increase the risk of antibiotic‑associated colitis, including Clostridioides difficile‑associated diarrhea.

Dosage of AUGMENTIN 1.2GM INJECTIONArrow

  • AUGMENTIN 1.2GM INJECTION is administered directly into a vein, either as a slow intravenous injection or as an intravenous infusion. This means it's delivered gradually over a specific period. It is crucial that this medication is administered by a qualified healthcare professional in a clinical setting. Self-administration is strictly prohibited.
  • The precise dosage and frequency of administration will be determined by your physician, taking into account the nature and severity of your medical condition, your age, weight, kidney function, and overall health. Because individual responses to medication vary, the dosage is tailored to each patient's specific needs.
  • It is imperative to adhere to the prescribed dosage and schedule provided by your healthcare provider. Do not attempt to adjust the dosage or frequency on your own, even if you feel better or worse. Any changes to the treatment plan should be discussed with your doctor. If you have any concerns or questions regarding your dosage, do not hesitate to ask your healthcare provider for clarification.

How to store AUGMENTIN 1.2GM INJECTION?Arrow

  • Keep AUGMENTIN 1.2GM INJ away from the reach of children and pets.
  • Store AUGMENTIN 1.2GM INJ at room temperature.

Benefits of AUGMENTIN 1.2GM INJECTIONArrow

  • AUGMENTIN 1.2GM INJECTION is a powerful combination medication containing Amoxycillin and Clavulanic Acid, working synergistically to combat bacterial infections. Amoxycillin, a penicillin-based antibiotic, targets bacteria by disrupting the formation of their cell walls. These cell walls are crucial structural components, essential for bacterial survival. By preventing their formation, Amoxycillin effectively weakens and destroys the bacteria, leading to the resolution of the infection.
  • Clavulanic Acid plays a vital role in enhancing the effectiveness of Amoxycillin. It functions as a beta-lactamase inhibitor, meaning it reduces the activity of enzymes produced by certain bacteria that can inactivate Amoxycillin. By inhibiting these enzymes, Clavulanic Acid prevents the breakdown of Amoxycillin, ensuring that a higher concentration of the antibiotic remains active and available to fight the infection. This synergistic action makes AUGMENTIN 1.2GM INJECTION a more potent and reliable treatment option for a wider range of bacterial infections.
  • In essence, AUGMENTIN 1.2GM INJECTION provides a dual-pronged approach to tackling bacterial infections. Amoxycillin directly attacks the bacteria, while Clavulanic Acid protects Amoxycillin from being deactivated by bacterial enzymes. This combination ensures a more effective and comprehensive treatment, leading to faster recovery and reduced risk of antibiotic resistance.

How to use AUGMENTIN 1.2GM INJECTIONArrow

  • AUGMENTIN 1.2GM INJECTION is administered intravenously, either as a direct injection into a vein or as an infusion. This medication will be administered by a qualified healthcare professional. It is crucial not to attempt self-administration of this injection.
  • The precise dosage and frequency of administration will be determined by your physician, taking into account your specific medical condition, its severity, and your response to the treatment. Dosage regimens can vary considerably from person to person.
  • Your doctor will monitor your progress and adjust the dosage as needed. It's important to communicate any concerns or side effects you experience during the treatment to your healthcare provider.
  • Ensure you understand the purpose of this medication and follow your doctor's instructions carefully for optimal results. If you have any questions, don't hesitate to ask your healthcare provider for clarification.

FAQs

<p style="text-align:justify;">Are there any serious side effects of AUGMENTIN 1.2GM INJECTION?</p>Arrow

Serious side effects are rare, but they can occur. These include severe allergic reactions, liver damage, or a decrease in white blood cell count. 

<p style="text-align:justify;">How does the combination of AUGMENTIN 1.2GM INJECTION work?&nbsp;</p>Arrow

AUGMENTIN 1.2GM INJECTION is a penicillin-type antibiotic that works by stopping the growth of bacteria, while clavulanic acid extends the spectrum of amoxicillin's antibacterial activity and helps to prevent bacterial resistance. 

<p style="text-align:justify;">Can I still take AUGMENTIN 1.2GM INJECTION if I have had a previous allergic reaction to penicillin?</p>Arrow

If you have had a previous allergic reaction to penicillin, it's essential to inform your healthcare provider before starting treatment with AUGMENTIN 1.2GM INJECTION. Depending on the severity of your allergic reaction, your doctor may recommend an alternative medication. 

<p style="text-align:justify;">What should I do if I experience side effects?&nbsp;</p>Arrow

If you experience any side effects, contact your healthcare provider immediately. Sometimes, they may advise you to stop taking the medication or switch to a different medication. 

<p style="text-align:justify;">Can AUGMENTIN 1.2GM INJECTION be taken during pregnancy or breastfeeding?&nbsp;</p>Arrow

AUGMENTIN 1.2GM INJECTION can be taken during pregnancy or breastfeeding, but it's important to consult with a healthcare provider before taking any medication.

Is there a known interaction of AUGMENTIN 1.2GM INJECTION with other drugs?Arrow

NULL interaction of AUGMENTIN 1.2GM INJECTION with other drungs

What advice should I follow while taking AUGMENTIN 1.2GM INJECTION?Arrow

Report your doctor if you have or have a history of glandular fever, took treatment for liver or kidney problems, or have less urination. Taking AUGMENTIN 1.2GM INJECTION may worsen your existing condition. So inform if you any to you doctor. Regular kidney, liver, and urine tests will be taken to monitor its function. Notify your doctor if you take or take any other medicine. Underlying kidney conditions, patients should avoid discussion about dose alteration. Inform your doctor if you experience any side effects. Talk to your doctor if you are planning or are already pregnant or breastfeeding. 

Which molecule/combination is used for making AUGMENTIN 1.2GM INJECTION?Arrow

AMOXYCILLIN,CLAVULANIC ACID is molecule/combination used for making AUGMENTIN 1.2GM INJECTION.

For what type of infection is AUGMENTIN 1.2GM INJECTION prescribed?Arrow

AUGMENTIN 1.2GM INJECTION is prescribed for Infectious Diseases.

What is Inj Augmentin and what is it used for?Arrow

Inj Augmentin is an injectable combination antibiotic containing amoxicillin and clavulanic acid. It is used to treat moderate to severe bacterial infections caused by susceptible organisms, particularly when resistance to amoxicillin alone is likely. Common uses include infections of the lungs and airways (such as pneumonia and severe bronchitis), complicated urinary tract infections, intra‑abdominal infections, skin and soft tissue infections, bone and joint infections, and certain gynecological or postoperative infections. The decision to use the injectable form is made by a doctor based on the severity of the infection and the patient’s ability to take oral medication.

How does Inj Augmentin work against bacteria?Arrow

Inj Augmentin contains two active components that work together. Amoxicillin is a penicillin‑class antibiotic that kills bacteria by interfering with the formation of their cell wall, which is essential for bacterial survival. Some bacteria produce enzymes called beta‑lactamases that can break down amoxicillin and make it ineffective. Clavulanic acid inhibits many of these beta‑lactamase enzymes, protecting amoxicillin from inactivation and extending its spectrum of activity. This combination allows Inj Augmentin to treat infections caused by many beta‑lactamase‑producing bacteria that would otherwise be resistant to amoxicillin alone.

How is Inj Augmentin given and who administers it?Arrow

Inj Augmentin is given only by healthcare professionals, usually in a hospital or clinical setting. It is administered by intravenous route, either as a slow injection or as an infusion diluted in a suitable fluid over a specified period. The exact method, dose, and frequency are determined by the treating physician based on the type and severity of infection, the patient’s age and body weight, and kidney and liver function. Patients should not attempt to self‑inject this medicine. If outpatient intravenous therapy is arranged, it should still be supervised by trained medical staff.

What are the common side effects of Inj Augmentin?Arrow

Common side effects of Inj Augmentin include gastrointestinal symptoms such as diarrhea, loose stools, nausea, vomiting, and abdominal discomfort. Some patients may experience headache, dizziness, or mild skin rash. Local reactions at the injection site, such as pain, redness, or inflammation, can also occur. These effects are often mild and temporary, but persistent or severe symptoms should be reported to the healthcare provider. Because this medicine can disturb normal gut bacteria, there is a risk of antibiotic‑associated colitis, including Clostridioides difficile‑associated diarrhea, particularly with prolonged use.

Can Inj Augmentin cause allergic reactions?Arrow

Yes, Inj Augmentin can cause allergic reactions, especially in individuals who are allergic to penicillins, cephalosporins, or other beta‑lactam antibiotics. Reactions may range from mild skin rash and itching to severe, potentially life‑threatening anaphylaxis. Signs of a serious allergic reaction include sudden rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, wheezing, or a sudden drop in blood pressure. These require immediate medical attention. Patients should always inform their doctor about any previous allergic reactions to antibiotics before receiving Inj Augmentin.

Is Inj Augmentin safe to use in patients with kidney problems?Arrow

Inj Augmentin can be used in patients with kidney impairment, but dose adjustment or extension of the dosing interval is often required because amoxicillin and its metabolites are primarily eliminated by the kidneys. In patients with significantly reduced kidney function, accumulation of the drug can increase the risk of side effects, including seizures in predisposed individuals. The treating physician will assess kidney function, usually by estimating creatinine clearance or glomerular filtration rate, and will modify the dosing regimen accordingly. Such patients should be monitored closely during therapy.

Can Inj Augmentin affect liver function?Arrow

Inj Augmentin has been associated with liver‑related side effects in some patients. These may include elevations in liver enzymes, cholestatic jaundice, or hepatitis. Such reactions are generally reversible after discontinuation but can occasionally be serious. The risk appears higher in older adults, males, and with prolonged or repeated courses. Patients with pre‑existing liver disease should use this medicine with caution, and liver function tests may be monitored during treatment. Symptoms such as persistent nausea, vomiting, dark urine, pale stools, severe fatigue, or yellowing of the skin or eyes should be reported immediately.

Can Inj Augmentin be used during pregnancy?Arrow

Amoxicillin–clavulanic acid has been used during pregnancy when clearly needed, and available human data do not suggest a major increase in the risk of congenital malformations. However, as with all medicines, Inj Augmentin should be used during pregnancy only if the potential benefit justifies any potential risk to the mother and fetus. The decision is made by the treating physician after assessing the severity of the infection and alternative options. Pregnant patients should not start or stop this medicine on their own and should inform their doctor if they are pregnant or planning pregnancy.

Is Inj Augmentin compatible with breastfeeding?Arrow

Both amoxicillin and clavulanic acid pass into breast milk in small amounts. They are generally considered compatible with breastfeeding, but the infant should be observed for possible effects such as diarrhea, candidiasis (oral thrush or diaper rash), or rash. In most cases, breastfeeding can continue while the mother receives this antibiotic, provided the infant is monitored and the treatment is clinically necessary. The prescribing doctor will weigh the benefits of treatment for the mother against any potential risks to the breastfed child and may adjust therapy if concerning symptoms appear in the infant.

What precautions should I follow while receiving Inj Augmentin?Arrow

Before and during treatment with Inj Augmentin, inform your healthcare provider about any history of allergy to penicillins, cephalosporins, or other medicines; any liver or kidney disease; and all other medications or supplements you are taking. Do not use this medicine for viral infections such as colds or flu. Report any severe or persistent diarrhea, especially if it is watery or contains blood, as this may indicate antibiotic‑associated colitis. Inform your doctor if you develop skin rash, itching, breathing difficulty, yellowing of the eyes or skin, dark urine, or unusual bruising or bleeding. Complete the full prescribed course unless your doctor advises otherwise.

Can Inj Augmentin interact with other medicines?Arrow

Yes, Inj Augmentin can interact with certain medicines. For example, it may affect the action of oral anticoagulants such as warfarin, potentially altering blood clotting parameters and increasing bleeding risk, so closer monitoring of coagulation tests may be required. Concomitant use with certain drugs that affect kidney function or are eliminated by the kidneys may influence blood levels of one or both agents. Allopurinol taken with amoxicillin has been associated with an increased risk of skin rash. High‑dose or prolonged use with other antibiotics can alter gut flora more extensively. Always inform your doctor about all prescription medicines, over‑the‑counter products, and herbal supplements you are using so that potential interactions can be assessed and monitored.

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Marketer / Manufacturer Details

GSK (GLAXO SMITHKLINE) PHARMACEUTICALS LIMITED

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India

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augmentin 1.2gm injection

AUGMENTIN 1.2GM INJECTION

MRP

157.52

₹127

19.38 % OFF

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