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Content Reviewed By:
Dr. Sanjay Mehta
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. CLONIL 25MG TABLET 15'S can cause several side effects.

Heart and Blood Pressure
Use with cautionClonil 25 can affect heart rhythm and blood pressure due to its tricyclic antidepressant properties.
Yes, CLONIL 25MG TABLET 15'S can cause impotence. Both men and women may experience decreased sexual desire and inability to have an organsm. In males, difficulty in maintaining erection (impotence) or painful ejaculation may be observed. You should consult your doctor immediately if you face any such problems while taking CLONIL 25MG TABLET 15'S.
Yes, CLONIL 25MG TABLET 15'S is safe to use if taken in the dose and duration prescribed by the doctor. CLONIL 25MG TABLET 15'S is a medicine that treats Obsessive-Compulsive Disorder (OCD), stabilises mood and behavior. It restores the chemical imbalance in the brain and creates a feeling of well being.
CLONIL 25MG TABLET 15'S may cause side effects like difficulty or inability to pass urine, altered libido, constipation, dryness in mouth, ejaculation disorder, indigestion and sleepiness. Please consult your doctor if these side effects worry you. The doctor may suggest ways to treat or prevent them.
If you have taken an overdose of CLONIL 25MG TABLET 15'S, you may experience symptoms such as drowsiness, restlessness, agitation and delirium (disturbed state of mind with restlessness and mental confusion). You may also experience severe sweating, fast heartbeat, feeling of faint, seizures (fits), and you may even go into a state of coma. Immediately consult your doctor and seek medical help if you think you have taken too much of this medicine.
No, do not stop taking CLONIL 25MG TABLET 15'S suddenly even if you are feeling better as it may worsen your condition and also cause withdrawal symptoms such as dizziness, nausea, vomiting, headache, weakness, sleep problems, fever, and irritability. Continue taking CLONIL 25MG TABLET 15'S for the duration as prescribed by your doctor to get maximum benefit. If any of the side effects are bothering you, consult your doctor. In case you have completed your course of treatment, your doctor will reduce your dose gradually before taking you off this medicine completely.
Clonil 25 is a brand of clomipramine, a tricyclic antidepressant. It is primarily used to treat obsessive–compulsive disorder (OCD), where it helps reduce intrusive thoughts and repetitive behaviors. It may also be prescribed for certain depressive disorders, panic disorder, and other anxiety‑related conditions, depending on a specialist’s judgment. The decision to use Clonil 25 is based on an assessment of symptoms, medical history, and response to previous treatments.
Clonil 25 contains clomipramine, which works mainly by inhibiting the reuptake of serotonin and, to a lesser extent, norepinephrine in the brain. By blocking their reuptake into nerve cells, it increases the levels of these neurotransmitters in the synaptic cleft, enhancing neurotransmission in pathways involved in mood and anxiety regulation. This mechanism is thought to underlie its benefits in OCD and depression, although the full therapeutic effect typically appears only after several weeks of continuous use.
The onset of benefit with Clonil 25 is gradual. Some people may notice mild improvement in sleep or anxiety within 1 to 2 weeks, but significant reduction in obsessive thoughts, compulsions, or depressive symptoms often requires 3 to 6 weeks or longer of regular treatment. The exact timeframe varies between individuals. It is important not to stop the medicine prematurely because of delayed response; any concerns about lack of improvement should be discussed with the prescribing doctor.
Clonil 25 should not be stopped abruptly unless a doctor specifically instructs you to do so for safety reasons. Sudden discontinuation can lead to withdrawal‑like symptoms such as nausea, headache, dizziness, irritability, sleep disturbance, and a rapid return or worsening of the underlying condition. When treatment needs to be stopped, the dose is usually reduced gradually over days to weeks under medical supervision to minimize these risks.
Common side effects of Clonil 25 include dry mouth, constipation, blurred vision, drowsiness, dizziness, increased sweating, tremor, and changes in appetite or weight. Some people may experience palpitations, mild changes in blood pressure, or sexual dysfunction such as decreased libido or difficulty with orgasm. Many of these effects are related to the anticholinergic and sedative properties of clomipramine and may lessen as the body adapts. Persistent, severe, or distressing side effects should be reported to a healthcare professional.
Yes, although serious adverse effects are less common, they can occur and require prompt medical attention. These include significant changes in heart rhythm, chest pain, severe dizziness or fainting, seizures, marked confusion, severe constipation with abdominal pain, difficulty urinating, and signs of allergic reaction such as rash, swelling of the face or tongue, or breathing difficulty. Mood or behavior changes, including new or worsening suicidal thoughts, agitation, or unusual aggression, particularly in younger patients, also warrant urgent evaluation.
Clonil 25 can interact with several other psychiatric medicines, and combinations must be carefully managed by a specialist. It should not be used with monoamine oxidase inhibitors (MAOIs) or within a specified washout period because of the risk of serious reactions. Combining clomipramine with other serotonergic drugs, such as certain SSRIs, SNRIs, or triptans, can increase the risk of serotonin syndrome, a potentially life‑threatening condition. It may also interact with antipsychotics, mood stabilizers, and medicines that affect heart rhythm. Always inform your doctor about all medicines you are taking before starting Clonil 25.
Clonil 25 is not considered addictive in the way that substances of abuse are, and it does not typically produce craving or drug‑seeking behavior. However, the body can become accustomed to its presence, and abrupt discontinuation may lead to withdrawal‑like symptoms and symptom rebound. For this reason, it should be taken exactly as prescribed and tapered gradually when it is time to stop, under medical guidance.
Alcohol is generally discouraged while taking Clonil 25. Both alcohol and clomipramine depress the central nervous system and can increase drowsiness, dizziness, impaired coordination, and judgment. This combination may raise the risk of accidents, falls, and other adverse events. In some individuals, alcohol can also worsen mood or anxiety symptoms and interfere with the therapeutic effect of the medicine. If you consume alcohol, discuss this with your doctor for individualized advice.
If you miss a dose of Clonil 25, take it as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects such as excessive drowsiness, heart rhythm changes, or other adverse reactions. If you frequently forget doses, speak with your healthcare provider about strategies to improve adherence.
Clonil 25 can be used in older adults, but it requires particular caution. Older patients are more sensitive to side effects such as confusion, dizziness, low blood pressure on standing, urinary retention, constipation, and heart rhythm disturbances. They also have a higher risk of falls and fractures. Doses are often started lower and adjusted more slowly, with close monitoring of blood pressure, heart function, and overall tolerability. Any sudden change in mental status, balance, or urinary habits should be reported promptly.
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