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Composition
Content Reviewed By:
Dr. Rajesh Sharma
, (MBBS)
Written By:
Ms. Priyanka Shah
, (B.Pharm)

Respiratory Conditions
Use with extreme cautionCodistar NF syrup can depress respiratory drive and should be used with extreme caution in patients with pre-existing respiratory conditions such as chronic obstructive pulmonary disease, asthma, or sleep apnoea.
Codistar NF syrup is used for short-term relief of dry, non-productive cough, particularly when it is severe, persistent, or disturbing sleep. It combines codeine, an opioid cough suppressant, with triprolidine, an antihistamine that helps relieve associated allergic symptoms such as runny nose and sneezing. It is generally prescribed in acute upper respiratory tract infections or allergic conditions where there is little or no mucus production.
Codeine in Codistar NF syrup acts on the cough centre in the brain to reduce the urge to cough, thereby decreasing the frequency and intensity of coughing episodes. Triprolidine blocks histamine H1 receptors, reducing symptoms such as sneezing, nasal discharge, and itching that often accompany respiratory infections or allergies. The combination provides symptomatic relief from dry, irritating cough and related upper respiratory symptoms.
Codistar NF syrup is not generally recommended for wet or productive cough, where mucus or phlegm is being brought up from the lungs. Suppressing a productive cough can interfere with the clearance of secretions and may worsen underlying infection or airway obstruction. If your cough is associated with significant sputum production, you should consult a doctor for an appropriate expectorant or other targeted treatment instead of using a codeine-based suppressant.
Safety of Codistar NF syrup in children depends on age and local regulatory guidance for codeine-containing products. In many countries, codeine is contraindicated in children below a certain age (often 12 years, and sometimes up to 18 years in specific high-risk groups) due to the risk of serious respiratory depression, especially in ultra-rapid metabolisers of codeine. It must not be used in children who have had tonsillectomy or adenoidectomy for obstructive sleep apnoea. Always follow your doctor’s advice and the approved product information for age restrictions.
Common side effects of Codistar NF syrup include drowsiness, dizziness, sedation, constipation, nausea, vomiting, dry mouth, blurred vision, and mild headache. Some people may also experience difficulty concentrating or mild confusion, especially at higher doses or when combined with other sedating medicines. If side effects are severe, persistent, or concerning, you should contact your healthcare provider promptly.
Yes. Because Codistar NF syrup contains codeine, an opioid, there is a risk of physical and psychological dependence, particularly with prolonged use, high doses, or misuse. It should be used only for the shortest duration necessary and strictly as prescribed. Patients with a history of substance use disorder require particular caution and close monitoring. Do not increase the dose or duration on your own, and do not share this medicine with others.
Driving or operating machinery while taking Codistar NF syrup is not advisable, especially when you first start treatment or after any dose change. Both codeine and triprolidine can cause drowsiness, dizziness, slowed reaction time, and impaired judgment. These effects may be intensified if you consume alcohol or take other central nervous system depressants. You should only drive or operate machinery if you are certain that you are fully alert and unaffected.
Use of Codistar NF syrup during pregnancy is not routinely recommended and should only occur if the potential benefit to the mother clearly outweighs the potential risk to the fetus, as assessed by a physician. Codeine crosses the placenta and, especially with prolonged use or near term, may cause neonatal respiratory depression or withdrawal symptoms in the newborn. Pregnant women should consult their doctor before using any codeine-containing medicine.
Caution is required when considering Codistar NF syrup during breastfeeding. Codeine is excreted into breast milk and, in mothers who are ultra-rapid metabolisers, higher-than-expected levels of morphine may be present, potentially causing serious adverse effects, including excessive sleepiness and respiratory depression, in the breastfed infant. Many guidelines advise avoiding codeine during breastfeeding. A breastfeeding mother should discuss safer alternatives with her healthcare provider before using this medicine.
If you miss a dose of Codistar NF syrup and it is still some time before your next scheduled dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one, as this increases the risk of side effects such as excessive drowsiness and respiratory depression. If you are unsure, seek advice from your doctor or pharmacist.
Codistar NF syrup should be avoided in individuals with known hypersensitivity to codeine, triprolidine, other opioids, or antihistamines; in patients with significant respiratory depression, acute asthma, or severe chronic obstructive pulmonary disease; in those with acute alcohol intoxication or concurrent use of potent central nervous system depressants without medical supervision; in patients with severe hepatic impairment or acute head injury; and in children below the minimum approved age for codeine use or those who have undergone tonsillectomy or adenoidectomy for obstructive sleep apnoea. People with a history of opioid misuse or dependence should only use it under specialist supervision.
Codistar NF syrup can interact with several other medicines. Concomitant use with other central nervous system depressants, such as benzodiazepines, sedative antihistamines, certain antidepressants, antipsychotics, alcohol, or other opioids, can increase the risk of profound sedation, respiratory depression, and low blood pressure. Some antidepressants and other drugs that affect CYP2D6 may alter the metabolism of codeine, changing its effectiveness and safety profile. Always inform your doctor and pharmacist about all prescription medicines, over-the-counter products, and herbal supplements you are taking before starting Codistar NF syrup.
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Reviewed on 03-02-2024
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MANKIND PHARMA LIMITED
Country of Origin -
India
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