DERIVA CMS GEL 20 GM

How DERIVA CMS GEL 20 GM Works

• DERIVA CMS Gel 20 GM is a combination medication designed to combat acne vulgaris, a common skin condition characterized by pimples, blackheads, and inflammation. It contains three active ingredients: Clindamycin, Adapalene, and Benzoyl Peroxide, each working through different mechanisms to provide a comprehensive approach to acne treatment.
• Clindamycin is an antibiotic that inhibits the growth of acne-causing bacteria, specifically *Cutibacterium acnes* (formerly known as *Propionibacterium acnes*). These bacteria contribute to acne by colonizing hair follicles and triggering inflammation. Clindamycin works by binding to the bacterial ribosome, thereby interfering with protein synthesis. This disruption of protein production effectively stops the bacteria from multiplying, reducing the bacterial load on the skin and decreasing inflammation.
• Adapalene is a retinoid-like compound that helps to normalize skin cell turnover. In acne-prone skin, the shedding of skin cells is often irregular, leading to clogged pores and the formation of comedones (blackheads and whiteheads). Adapalene binds to specific retinoic acid receptors in the skin cells, promoting differentiation and reducing the stickiness of the cells. This action prevents the accumulation of dead skin cells within the pores, thereby reducing the formation of new comedones and helping to clear existing ones. Adapalene also possesses anti-inflammatory properties, which further contribute to its effectiveness in treating acne.
• Benzoyl Peroxide is a powerful oxidizing agent that kills *Cutibacterium acnes* bacteria and helps to unclog pores. It works by releasing free radicals that oxidize bacterial proteins, leading to bacterial cell death. Additionally, Benzoyl Peroxide has a comedolytic effect, meaning it helps to break down comedones and prevent their formation. It also reduces inflammation associated with acne lesions. The combination of antibacterial and comedolytic actions makes Benzoyl Peroxide a crucial component in treating acne.
• In summary, DERIVA CMS Gel works synergistically to target multiple factors contributing to acne. Clindamycin reduces bacterial growth, Adapalene normalizes skin cell turnover and reduces inflammation, and Benzoyl Peroxide kills bacteria and unclogs pores. This triple-action approach provides a comprehensive treatment for acne vulgaris, helping to reduce the number of acne lesions, prevent new breakouts, and improve the overall appearance of the skin. It is important to use this medication as directed by a healthcare professional to maximize its effectiveness and minimize potential side effects, such as skin irritation or dryness.

Common side effects of Deriva CMS Gel may include dry skin, peeling, redness, burning sensation, itching, and skin irritation. Uncommon side effects may include allergic reactions (rash, hives, swelling), changes in skin color (hyperpigmentation or hypopigmentation), increased sensitivity to sunlight, acne flare-ups, and temporary worsening of acne.

• If you forget to apply DERIVA CMS GEL 20 GM at the regular time, apply it as soon as you remember.
• However, if it is almost time for your next application, skip the missed dose and continue with your regular dosing schedule.
• Do not apply a double dose to make up for a missed one.

• Keep DERIVA CMS GEL 20GM away from the reach of children and pets.
• Store DERIVA CMS GEL 20GM at room temperature.

• Wash your face gently with a mild cleanser and pat dry before applying Deriva CMS Gel. Avoid harsh scrubs or abrasive cleansers.
• Apply a thin layer of Deriva CMS Gel to the affected areas once daily, preferably in the evening. Avoid applying to unaffected skin.
• Use Deriva CMS Gel consistently as directed by your doctor, even if you don't see immediate results. It may take several weeks to notice improvement.
• Avoid prolonged sun exposure while using Deriva CMS Gel. Wear sunscreen with an SPF of 30 or higher during the day, even on cloudy days. This medication can make your skin more sensitive to the sun.
• Do not use other topical acne medications or cosmetics containing alcohol, astringents, or exfoliants on the same areas where you apply Deriva CMS Gel unless specifically directed by your doctor, as they may cause increased irritation or dryness. Also, if you experience excessive dryness or peeling, consult your doctor. They may recommend using a moisturizer or adjusting the frequency of application. Be patient and persistent with your treatment. Acne treatment takes time, and consistency is key to achieving the best results. Inform your doctor about all medications you are currently taking, including over-the-counter drugs and herbal supplements, as they may interact with Deriva CMS Gel.
• If irritation occurs, reduce the frequency of application or discontinue use and consult your doctor. Do not apply to broken or irritated skin.
• Keep Deriva CMS Gel away from your eyes, mouth, and nostrils. If accidental contact occurs, rinse thoroughly with water.
• Store Deriva CMS Gel at room temperature, away from heat and direct sunlight. Keep out of reach of children.

• There are no known food interactions with DERIVA CMS GEL 20 GM. It is a topical medication, and its absorption into the bloodstream is minimal. Therefore, it is unlikely to be affected by the food you consume. However, if you experience any unusual side effects, consult your doctor.