GEMER SITA IR 50/500/1 TABLET 10'S
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GEMER SITA IR 50/500/1 TABLET 10'S
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GEMER SITA IR 50/500/1 TABLET 10'S

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GEMER SITA IR 50/500/1 TABLET 10'S

By SUN PHARMACEUTICAL INDUSTRIES LTD

MRP

129

₹109.65

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10

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About GEMER SITA IR 50/500/1 TABLET 10'S

  • GEMER SITA IR 50/500/1 is a triple combination oral antidiabetic medication used to manage type 2 diabetes mellitus. It combines three active ingredients: Gliclazide, Metformin Hydrochloride (HCl), and Sitagliptin. This medication is typically prescribed when diet, exercise, and single or dual therapy with other antidiabetic drugs are insufficient to achieve adequate glycemic control.
  • Gliclazide belongs to the sulfonylurea class of drugs. It works by stimulating the release of insulin from the beta cells of the pancreas. Insulin helps to lower blood sugar levels by allowing glucose to enter cells for energy production. By increasing insulin secretion, Gliclazide effectively reduces hyperglycemia, particularly after meals.
  • Metformin HCl is a biguanide that decreases glucose production in the liver and improves insulin sensitivity in peripheral tissues. It reduces the amount of glucose absorbed from food and increases glucose utilization by the body's cells. Metformin is often the first-line treatment for type 2 diabetes due to its effectiveness and relatively low risk of hypoglycemia when used alone.
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by preventing the breakdown of incretin hormones, such as GLP-1 (glucagon-like peptide-1), which are released in response to meals. By prolonging the activity of incretin hormones, Sitagliptin increases insulin release and decreases glucagon secretion in a glucose-dependent manner. This helps to lower blood sugar levels without the risk of hypoglycemia.
  • GEMER SITA IR 50/500/1 is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are already treated with a combination of gliclazide and metformin or in patients who are not adequately controlled on metformin alone. The specific dosage is determined by a healthcare professional based on individual patient needs and blood glucose levels. It is crucial to take the medication as prescribed and to monitor blood glucose levels regularly. Patients should also be aware of potential side effects and drug interactions and should consult their doctor or pharmacist for any concerns.

Uses of GEMER SITA IR 50/500/1 TABLET 10'S

  • Treatment of Type 2 diabetes mellitus
  • Lowering high blood sugar levels
  • Improving blood sugar control
  • Used in conjunction with diet and exercise
  • Used in combination with other diabetes medications (in some cases)

How GEMER SITA IR 50/500/1 TABLET 10'S Works

  • GEMER SITA IR 50/500/1 TABLET 10'S is a combination medicine designed to manage type 2 diabetes effectively. It combines three active ingredients: glimepiride, metformin, and sitagliptin, each working through different mechanisms to lower blood glucose levels.
  • Glimepiride belongs to a class of drugs called sulfonylureas. It works by stimulating the pancreas to release more insulin. Insulin is a hormone that helps glucose (sugar) move from the blood into the body's cells, where it's used for energy. By increasing insulin secretion, glimepiride helps lower blood sugar levels, particularly after meals.
  • Metformin is a biguanide that works primarily by decreasing glucose production in the liver. The liver naturally produces glucose, but in people with diabetes, this production can be excessive. Metformin reduces this overproduction. Additionally, metformin improves insulin sensitivity, meaning that the body's cells become more responsive to insulin, allowing them to take up glucose more efficiently. It also slightly reduces glucose absorption from the intestines.
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. DPP-4 is an enzyme that breaks down incretin hormones. Incretins are released by the intestine throughout the day and especially during a meal. These hormones increase insulin release and decrease glucagon secretion (a hormone that raises blood sugar). By inhibiting DPP-4, sitagliptin increases incretin levels, which in turn enhances insulin release and reduces glucagon secretion, leading to better blood sugar control.
  • In summary, GEMER SITA IR 50/500/1 TABLET 10'S works through a triple-pronged approach: glimepiride boosts insulin release, metformin reduces glucose production and improves insulin sensitivity, and sitagliptin enhances the effects of incretin hormones. This combination helps to maintain stable blood sugar levels throughout the day, especially after meals, providing comprehensive glycemic control for individuals with type 2 diabetes. This coordinated action addresses multiple aspects of the disease, resulting in improved blood sugar management compared to using any single drug alone. Always take this medicine exactly as prescribed by your doctor.

Side Effects of GEMER SITA IR 50/500/1 TABLET 10'SArrow

Common side effects of GEMER SITA IR 50/500/1 Tablet may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and hypoglycemia (low blood sugar). Other possible side effects are headache, dizziness, fatigue, constipation, upper respiratory tract infection, and weight gain. Less common but potentially serious side effects could involve allergic reactions (rash, itching, swelling), liver problems (jaundice, dark urine), kidney problems, pancreatitis, and lactic acidosis (muscle cramps, rapid breathing). In rare cases, blood disorders such as anemia or thrombocytopenia might occur. This is not an exhaustive list, and patients should report any unusual symptoms to their doctor.

Safety Advice for GEMER SITA IR 50/500/1 TABLET 10'SArrow

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Allergies

Allergies

Do not use Gemer Sita IR 50/500/1 Tablet 10's if you are allergic to it.

Dosage of GEMER SITA IR 50/500/1 TABLET 10'SArrow

  • The dosage of GEMER SITA IR 50/500/1 TABLET 10'S is individualized and determined by your physician based on your specific needs, blood glucose levels, and response to treatment. It is crucial to strictly adhere to your doctor's instructions regarding the dosage and timing of administration. Typically, this medication is taken orally, and the number of tablets you take each day, as well as the frequency, will be determined by your doctor.
  • As a general guideline, the starting dose is usually one tablet once or twice daily, taken with meals to help reduce gastrointestinal side effects and improve absorption. Your doctor may gradually increase the dosage as needed to achieve optimal blood glucose control. The maximum daily dose should not exceed the maximum recommended dose of each individual component of GEMER SITA IR 50/500/1 TABLET 10'S.
  • It is important to monitor your blood glucose levels regularly as directed by your doctor to assess the effectiveness of the medication and adjust the dosage accordingly. Inform your doctor about any other medications you are taking, as they may interact with GEMER SITA IR 50/500/1 TABLET 10'S and affect your blood glucose control. Dosage adjustments may be necessary if you experience side effects or if there are changes in your kidney or liver function. Never adjust your dosage without consulting your doctor.
  • Take 'GEMER SITA IR 50/500/1 TABLET 10'S' only as per the prescription by your physician only

What if I miss my dose of GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

  • If you miss a dose of GEMER SITA IR 50/500/1 Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How to store GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

  • Keep GEMER SITA IR 50/500/1MG TAB 1X10 away from the reach of children and pets.
  • Store GEMER SITA IR 50/500/1MG TAB 1X10 at room temperature.

Benefits of GEMER SITA IR 50/500/1 TABLET 10'SArrow

  • GEMER SITA IR 50/500/1 Tablet is a combination medicine used to treat type 2 diabetes mellitus when diet and exercise alone are not enough to control blood sugar levels effectively. It combines three different medications to provide comprehensive glycemic control.
  • The primary benefit of GEMER SITA IR 50/500/1 Tablet lies in its ability to lower blood sugar levels. By improving insulin sensitivity, stimulating insulin release, and reducing glucose production in the liver, it helps maintain stable blood sugar levels throughout the day. This is crucial in preventing the long-term complications associated with diabetes, such as nerve damage (neuropathy), kidney damage (nephropathy), eye damage (retinopathy), and cardiovascular problems.
  • GEMER SITA IR 50/500/1 Tablet improves insulin sensitivity in peripheral tissues like muscles and fat, allowing cells to utilize glucose more effectively. This reduces insulin resistance, a common problem in type 2 diabetes, and helps lower blood sugar levels after meals.
  • It stimulates the pancreas to release more insulin, especially after meals when blood sugar levels tend to rise. This helps to quickly lower post-meal blood sugar spikes and maintain overall glycemic control.
  • GEMER SITA IR 50/500/1 Tablet reduces the production of glucose in the liver, which is another key mechanism in controlling blood sugar levels. In people with diabetes, the liver often produces excessive amounts of glucose, contributing to hyperglycemia. By inhibiting this process, the tablet helps lower fasting blood sugar levels.
  • Because GEMER SITA IR 50/500/1 Tablet combines three medications, it offers a synergistic effect in controlling blood sugar. This means that the combined effect of the three drugs is greater than the sum of their individual effects. This results in more effective blood sugar control compared to using any of the medications alone.
  • Effective management of blood sugar levels with GEMER SITA IR 50/500/1 Tablet can lead to significant improvements in overall health and well-being. By preventing or delaying the onset of diabetes-related complications, it can help individuals with type 2 diabetes live longer, healthier lives.
  • GEMER SITA IR 50/500/1 Tablet simplifies the medication regimen for individuals with type 2 diabetes who require multiple medications. By combining three drugs into a single tablet, it reduces the pill burden and makes it easier for patients to adhere to their treatment plan. This can improve compliance and lead to better blood sugar control.
  • GEMER SITA IR 50/500/1 Tablet contributes to cardiovascular health by helping to control blood sugar levels, which is a major risk factor for heart disease in people with diabetes. Maintaining stable blood sugar levels can reduce the risk of heart attacks, strokes, and other cardiovascular events.
  • By effectively managing blood sugar levels and preventing complications, GEMER SITA IR 50/500/1 Tablet can improve the quality of life for individuals with type 2 diabetes. It allows them to lead more active and fulfilling lives without the constant worry of diabetes-related health problems.

How to use GEMER SITA IR 50/500/1 TABLET 10'SArrow

  • GEMER SITA IR 50/500/1 TABLET 10'S should be taken orally, usually once or twice daily, as directed by your doctor. It's best to take it with meals to minimize the risk of stomach upset. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medication is released and absorbed in your body. Maintaining a consistent schedule for taking your medication each day will help you remember to take it.
  • Your doctor will determine the appropriate dosage and duration of treatment based on your individual needs and response to the medication. It's crucial to follow your doctor's instructions precisely. Do not adjust the dosage or stop taking the medication without consulting your doctor, even if you feel better. Stopping the medication abruptly can lead to a sudden increase in blood sugar levels.
  • While taking GEMER SITA IR 50/500/1 TABLET 10'S, it's essential to monitor your blood sugar levels regularly, as directed by your doctor. Keep track of your readings and share them with your doctor during your appointments. This information will help your doctor adjust your treatment plan as needed. In addition to medication, lifestyle modifications such as diet and exercise are important for managing your diabetes. Follow a healthy diet that is low in sugar and saturated fat, and engage in regular physical activity.
  • Be aware of the potential side effects of GEMER SITA IR 50/500/1 TABLET 10'S, such as hypoglycemia (low blood sugar), nausea, and diarrhea. If you experience any concerning side effects, contact your doctor immediately. It is advisable to carry a source of fast-acting glucose, such as glucose tablets or juice, in case you experience symptoms of hypoglycemia. Also, inform your doctor about any other medications or supplements you are taking, as they may interact with GEMER SITA IR 50/500/1 TABLET 10'S. Regular follow-up appointments with your doctor are necessary to monitor your progress and adjust your treatment plan as needed.

Quick Tips for GEMER SITA IR 50/500/1 TABLET 10'SArrow

  • Take GEMER SITA IR 50/500/1 Tablet as prescribed by your doctor, usually once or twice daily with meals to minimize stomach upset. Consistency is key for optimal blood sugar control, so take it at the same time(s) each day.
  • Monitor your blood sugar levels regularly as directed by your healthcare provider. GEMER SITA IR helps manage blood sugar, but regular monitoring is essential to ensure the medication is working effectively and to adjust your treatment plan if needed. Keep a log of your readings to share with your doctor.
  • Follow a balanced diet and exercise regularly while taking GEMER SITA IR. This medication works best when combined with lifestyle changes. Focus on whole grains, lean proteins, and plenty of fruits and vegetables. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
  • Be aware of the symptoms of low blood sugar (hypoglycemia), such as shakiness, sweating, dizziness, or confusion. Carry a source of fast-acting sugar, like glucose tablets or fruit juice, in case your blood sugar drops too low. Discuss with your doctor how to manage hypoglycemia effectively.
  • Inform your doctor about all other medications, supplements, and herbal products you are taking before starting GEMER SITA IR. Drug interactions can affect how well this medication works and may increase the risk of side effects. Do not stop taking this medicine without consulting your doctor.

Food Interactions with GEMER SITA IR 50/500/1 TABLET 10'SArrow

  • GEMER SITA IR 50/500/1 TABLET 10'S should be taken orally, preferably with or immediately following a meal to minimize the risk of stomach upset. Consuming it with food also aids in better absorption of the medicine. Avoid excessive alcohol consumption while taking this medicine, as it may increase the risk of low blood sugar (hypoglycemia).

FAQs

What is GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

GEMER SITA IR 50/500/1 TABLET 10'S is a combination medicine used to control high blood sugar levels in people with type 2 diabetes mellitus.

How does GEMER SITA IR 50/500/1 TABLET 10'S work?Arrow

This medicine works as a combination of three drugs: Glimepiride, Sitagliptin and Metformin. Glimepiride is a sulfonylurea which increases the amount of insulin released by the pancreas. Sitagliptin is a DPP-4 inhibitor which works by increasing insulin release and decreasing glucagon production. Metformin is a biguanide which works by decreasing glucose production in the liver and improving the body's sensitivity to insulin.

What are the common side effects of GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

The most common side effects include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.

Is GEMER SITA IR 50/500/1 TABLET 10'S safe during pregnancy?Arrow

There is not enough information available about the safety of using this medicine during pregnancy. Therefore, it is important to talk to your doctor before using this medicine if you are pregnant or planning to become pregnant.

Is GEMER SITA IR 50/500/1 TABLET 10'S safe during breastfeeding?Arrow

It is not known whether this medicine passes into breast milk. Therefore, it is important to talk to your doctor before using this medicine if you are breastfeeding.

How to store GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

Store this medicine at room temperature, away from heat and moisture. Keep it out of reach of children and pets.

What if I miss a dose of GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time.

Is it safe to drink alcohol with GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

It is not safe to drink alcohol with GEMER SITA IR 50/500/1 TABLET 10'S. Alcohol can increase the side effects of this medicine, such as nausea, vomiting, diarrhea, and abdominal pain.

Can GEMER SITA IR 50/500/1 TABLET 10'S cause weight gain?Arrow

Yes, GEMER SITA IR 50/500/1 TABLET 10'S can cause weight gain.

Can GEMER SITA IR 50/500/1 TABLET 10'S cause low blood sugar (hypoglycemia)?Arrow

Yes, GEMER SITA IR 50/500/1 TABLET 10'S can cause low blood sugar (hypoglycemia), especially if you are also taking other diabetes medicines.

What precautions should I take while taking GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

While taking GEMER SITA IR 50/500/1 TABLET 10'S, you should avoid drinking alcohol, check your blood sugar levels regularly, and tell your doctor about any side effects.

Can GEMER SITA IR 50/500/1 TABLET 10'S interact with other medicines?Arrow

Yes, GEMER SITA IR 50/500/1 TABLET 10'S can interact with other medicines. Therefore, it is important to tell your doctor about all of your medicines before taking this medicine.

Is GEMER SITA IR 50/500/1 TABLET 10'S safe for people with kidney disease?Arrow

GEMER SITA IR 50/500/1 TABLET 10'S should be used with caution in people with kidney disease. This medicine is not recommended in people with certain forms of kidney disease.

What happens if I overdose on GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

An overdose of GEMER SITA IR 50/500/1 TABLET 10'S can cause low blood sugar (hypoglycemia). If you overdose on this medicine, get medical help right away.

Can I take other diabetes medicines with GEMER SITA IR 50/500/1 TABLET 10'S?Arrow

Talk to your doctor before taking other diabetes medicines with GEMER SITA IR 50/500/1 TABLET 10'S. Some diabetes medicines can interact with this medicine.

References

Book Icon

Sitagliptin Summary of Product Characteristics. Electronic Medicines Compendium. Contains detailed information on sitagliptin including its mechanism of action, pharmacokinetics, clinical trials, and safety data.

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DrugBank: Sitagliptin. Comprehensive information on sitagliptin, including its chemical structure, pharmacology, and therapeutic uses. Includes links to related research articles and databases.

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FDA Approved Label - Januvia (sitagliptin). Contains detailed information as approved by the FDA, including indications, dosage, contraindications, warnings, precautions, adverse reactions, and clinical studies.

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European Medicines Agency (EMA) - Januvia. Provides the European Public Assessment Report (EPAR) for Januvia (sitagliptin), including scientific discussion and regulatory information.

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FDA Medical Review(Metformin/Sitagliptin). Contains medical review on the combination of Metformin and Sitagliptin.

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Marketer / Manufacturer Details

SUN PHARMACEUTICAL INDUSTRIES LTD

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GEMER SITA IR 50/500/1 TABLET 10'S

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