GLUCRETA LM 10MG/5MG/500MG TABLET 10'S

How GLUCRETA LM 10MG/5MG/500MG TABLET 10'S Works

• GLUCRETA LM 10MG/5MG/500MG TABLET 10'S is a combination medication designed to manage blood sugar levels in individuals with type 2 diabetes. It combines three active ingredients: teneligliptin, metformin, and lobeglitazone, each working through different mechanisms to achieve comprehensive glycemic control.
• Teneligliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 inhibitors work by increasing the levels of incretin hormones in the body. Incretins are naturally occurring hormones that stimulate insulin release from the pancreas and decrease glucagon secretion from the alpha cells of pancreas, both of which are glucose-dependent. This means that they exert their effects primarily when blood sugar levels are high. By inhibiting the DPP-4 enzyme, teneligliptin prolongs the action of incretins, leading to improved blood sugar control. It enhances insulin secretion after meals and reduces the amount of glucose produced by the liver.
• Metformin is a biguanide that primarily works by decreasing glucose production in the liver and improving the body's sensitivity to insulin. It reduces hepatic glucose output by inhibiting gluconeogenesis and glycogenolysis, the processes by which the liver produces glucose. Additionally, metformin enhances insulin sensitivity in peripheral tissues, such as muscle, allowing cells to utilize glucose more effectively. It also slows down the absorption of glucose from the intestines, further contributing to lower blood sugar levels. Metformin does not typically cause hypoglycemia (low blood sugar) when used alone, as its primary action is to reduce glucose production rather than directly stimulating insulin release.
• Lobeglitazone is a thiazolidinedione (TZD) that improves insulin sensitivity in peripheral tissues. It works by activating peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor that plays a crucial role in glucose and lipid metabolism. Activation of PPARγ increases the expression of genes involved in insulin signaling and glucose uptake, leading to enhanced insulin sensitivity in muscle, adipose tissue, and the liver. By making the body more responsive to insulin, lobeglitazone helps lower blood sugar levels. It also has some effects on lipid metabolism, which can be beneficial for individuals with diabetes who often have associated lipid abnormalities.
• In summary, GLUCRETA LM 10MG/5MG/500MG TABLET 10'S works through a triple-pronged approach: teneligliptin enhances incretin activity to stimulate insulin release and reduce glucagon secretion, metformin reduces hepatic glucose production and improves insulin sensitivity, and lobeglitazone further enhances insulin sensitivity in peripheral tissues. This combination helps to lower blood sugar levels effectively in patients with type 2 diabetes, improving overall glycemic control and reducing the risk of diabetes-related complications. The synergistic action of these three drugs targets multiple pathways involved in glucose metabolism, providing a more comprehensive approach to diabetes management compared to single-agent therapy. It is important to take this medication as prescribed by your healthcare provider and to follow a healthy diet and exercise plan for optimal results.

The following side effects may occur while taking GLUCRETA LM 10MG/5MG/500MG TABLET: Common side effects include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, hypoglycemia (low blood sugar), headache, dizziness, and skin rash. Less common but potentially serious side effects include lactic acidosis (symptoms include rapid breathing, stomach pain, and muscle cramps), allergic reactions (rash, itching, swelling), liver problems (jaundice, dark urine), kidney problems, and decreased Vitamin B12 absorption. Contact your doctor immediately if you experience any serious or persistent side effects.

• If you miss a dose of GLUCRETA LM 10MG/5MG/500MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep GLUCRETA LM 10/5/500MG TAB 1X10 away from the reach of children and pets.
• Store GLUCRETA LM 10/5/500MG TAB 1X10 at room temperature.

• **Take GLUCRETA LM as prescribed:** Always adhere to your doctor's prescribed dosage and schedule. GLUCRETA LM should be taken orally, usually once or twice daily, with meals to minimize stomach upset and maximize absorption. Never adjust the dosage yourself; consult your healthcare provider for any necessary changes. Consistent timing is key for maintaining stable blood sugar levels.
• **Monitor your blood glucose regularly:** Regular blood glucose monitoring is crucial while taking GLUCRETA LM. Keep a log of your readings and share it with your doctor during check-ups. This helps them assess the effectiveness of the medication and adjust your treatment plan accordingly. Understanding how your body responds to GLUCRETA LM in different situations (before/after meals, exercise) enables proactive management of your diabetes.
• **Maintain a healthy diet:** GLUCRETA LM works best when combined with a balanced diet. Focus on consuming plenty of fruits, vegetables, and whole grains, while limiting your intake of sugary foods, processed snacks, and saturated fats. A registered dietitian or certified diabetes educator can help you create a personalized meal plan to meet your specific nutritional needs and support your diabetes management goals.
• **Engage in regular physical activity:** Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Activities like brisk walking, cycling, or swimming can improve insulin sensitivity, lower blood glucose levels, and enhance overall health. Consult your doctor before starting any new exercise program, especially if you have pre-existing health conditions. Remember to monitor your blood glucose levels before, during, and after exercise to prevent hypoglycemia (low blood sugar).
• **Be aware of potential side effects and interactions:** GLUCRETA LM, like all medications, can cause side effects. Common side effects include nausea, diarrhea, and hypoglycemia. Be particularly vigilant for signs of low blood sugar, such as dizziness, sweating, confusion, or shakiness. Carry a source of quick-acting glucose (glucose tablets, juice) with you at all times to treat hypoglycemia promptly. Inform your doctor about all other medications, supplements, and herbal remedies you are taking to avoid potential drug interactions.

• GLUCRETA LM 10MG/5MG/500MG TABLET 10'S can generally be taken with or without food. However, it's best to take it at the same time each day to maintain consistent blood sugar levels. Consult your doctor for specific dietary advice while taking this medication. Avoid excessive alcohol consumption, as it can increase the risk of low blood sugar (hypoglycemia).