KREVILD M TABLET 10'S

How KREVILD M TABLET 10'S Works

• KREVILD M TABLET 10'S is a combination medication designed to manage blood sugar levels in individuals with type 2 diabetes. It combines two active ingredients: vildagliptin and metformin, each working through different mechanisms to achieve optimal glycemic control. Vildagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, while metformin is a biguanide.
• Vildagliptin enhances the levels of incretin hormones in the body. Incretins, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine in response to food intake. These hormones play a crucial role in regulating glucose homeostasis. Vildagliptin works by inhibiting the DPP-4 enzyme, which is responsible for breaking down incretin hormones. By inhibiting DPP-4, vildagliptin increases the amount of active incretins in the body, prolonging their action. The increased incretin levels then stimulate insulin release from the pancreatic beta cells in a glucose-dependent manner. This means insulin is released when blood sugar levels are high, preventing hypoglycemia (low blood sugar). Incretins also suppress glucagon secretion from the pancreatic alpha cells. Glucagon is a hormone that raises blood sugar levels by stimulating the liver to release stored glucose. By reducing glucagon secretion, vildagliptin helps to lower blood sugar levels further. Ultimately, vildagliptin improves glycemic control by increasing insulin release and decreasing glucagon secretion in a glucose-dependent manner.
• Metformin, on the other hand, primarily works by decreasing glucose production in the liver. It achieves this by inhibiting hepatic gluconeogenesis, the process by which the liver converts non-carbohydrate sources (such as amino acids and glycerol) into glucose. Metformin also enhances insulin sensitivity in peripheral tissues, such as muscle and fat. This means that the body's cells become more responsive to insulin, allowing them to take up glucose from the bloodstream more effectively. Furthermore, metformin slows down the absorption of glucose from the intestine, which helps to prevent spikes in blood sugar levels after meals. By reducing hepatic glucose production, increasing insulin sensitivity, and slowing down glucose absorption, metformin effectively lowers blood sugar levels.
• The combination of vildagliptin and metformin in KREVILD M TABLET 10'S provides a dual mechanism of action to control blood sugar levels. Vildagliptin enhances incretin activity, leading to increased insulin release and decreased glucagon secretion, while metformin reduces hepatic glucose production, increases insulin sensitivity, and slows down glucose absorption. Together, these actions provide synergistic effects, resulting in improved glycemic control compared to either drug used alone. This combination helps to maintain stable blood sugar levels throughout the day, reducing the risk of both hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar).
• It is important to note that KREVILD M TABLET 10'S should be used as part of a comprehensive diabetes management plan that includes diet and exercise. Regular monitoring of blood sugar levels is also essential to ensure that the medication is working effectively and to adjust the dosage as needed. Patients should follow their healthcare provider's instructions carefully and report any side effects or concerns promptly.

Like all medicines, KREVILD M TABLET 10'S can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Nausea * Vomiting * Diarrhea * Abdominal pain * Loss of appetite * Headache * Dizziness * Metallic taste **Uncommon Side Effects (may affect up to 1 in 100 people):** * Skin rash * Itching * Urticaria (hives) * Fatigue * Sleep disturbances * Constipation **Rare Side Effects (may affect up to 1 in 1,000 people):** * Serious allergic reactions (anaphylaxis) - symptoms may include swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, and a sudden drop in blood pressure. * Liver problems (indicated by yellowing of the skin or eyes, dark urine, and pale stools) * Changes in blood counts **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Severe skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) - symptoms may include blistering and peeling of the skin. * Nerve damage (peripheral neuropathy) - symptoms may include numbness, tingling, or pain in the hands or feet. **If you experience any side effects, even those not listed above, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.**

• If you miss a dose of KREVILD M TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep KREVILD M 50/500MG TAB 1X10 away from the reach of children and pets.
• Store KREVILD M 50/500MG TAB 1X10 at room temperature.

• Take KREVILD M TABLET 10'S as prescribed by your doctor. Do not alter the dosage or stop taking the medication without consulting them, even if your symptoms improve. Consistent use ensures optimal blood sugar control.
• It's best to take KREVILD M TABLET 10'S with meals to minimize the risk of stomach upset or gastrointestinal side effects. Food helps to slow down the absorption of the medication, which can improve its effectiveness and reduce side effects.
• Monitor your blood sugar levels regularly as directed by your healthcare provider while taking KREVILD M TABLET 10'S. Keeping a record of your blood sugar readings will help you and your doctor assess how well the medication is working and make any necessary adjustments to your treatment plan.
• Inform your doctor about all other medications, supplements, and herbal products you are currently taking before starting KREVILD M TABLET 10'S. Some medications can interact with KREVILD M TABLET 10'S, affecting its efficacy or increasing the risk of side effects. This includes over-the-counter drugs and even certain herbal remedies.
• Maintain a healthy lifestyle, including a balanced diet and regular exercise, to complement the effects of KREVILD M TABLET 10'S. This holistic approach enhances the medication's ability to manage your blood sugar levels effectively and improves your overall health.

• While taking KREVILD M TABLET 10'S, it's generally recommended to follow your doctor's advice regarding dietary restrictions.
• This medication can be taken with or without food, but consistent timing relative to meals is advisable for optimal results.
• Avoid excessive alcohol consumption while on this medication, as it may increase the risk of side effects.