LEEVARIN 15 TABLET 10'S
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LEEVARIN 15 TABLET 10'S
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LEEVARIN 15 TABLET 10'S

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LEEVARIN 15 TABLET 10'S

By ADMAC LIFESCIENCES

MRP

₹

475

₹305

35.79 % OFF

₹30.5 Only /

Tablet

10

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Product DetailsArrow

About LEEVARIN 15 TABLET 10'S

  • LEEVARIN 15 TABLET 10'S contains leucovorin calcium, a substance related to folic acid (a B vitamin). It's used primarily in two ways: to counteract the effects of methotrexate, a medication used in cancer treatment and for other conditions that can deplete folic acid levels in the body, and to treat megaloblastic anemia resulting from folic acid deficiency. When methotrexate is used, LEEVARIN 15 TABLET 10'S acts as a 'rescue' medication, replenishing folic acid and reducing methotrexate's toxic effects on healthy cells.
  • This medication is crucial in chemotherapy regimens involving methotrexate. Methotrexate works by interfering with folic acid metabolism, which can harm both cancer cells and healthy cells. LEEVARIN 15 TABLET 10'S selectively protects healthy cells from methotrexate's effects, allowing for higher doses of methotrexate to be used and improving treatment outcomes. By providing a source of folic acid that bypasses the metabolic block caused by methotrexate, LEEVARIN 15 TABLET 10'S ensures that vital cellular processes can continue.
  • Additionally, LEEVARIN 15 TABLET 10'S is used to treat megaloblastic anemia, a condition characterized by abnormally large red blood cells due to insufficient folic acid. By providing the body with leucovorin calcium, a readily usable form of folic acid, LEEVARIN 15 TABLET 10'S helps to correct the underlying deficiency and restore normal red blood cell production.
  • Before taking LEEVARIN 15 TABLET 10'S, inform your doctor if you have any allergies to leucovorin calcium or any of the other ingredients in the medication. Also, let your doctor know if you have other forms of anemia, such as pernicious anemia or megaloblastic anemia due to vitamin B12 deficiency, as LEEVARIN 15 TABLET 10'S is not appropriate for these conditions. It's also important to discuss any existing kidney, heart, or liver problems with your doctor.
  • If you experience any allergic reactions such as wheezing, difficulty breathing, skin rash, itching, hives, or swelling of the lips, face, or tongue, seek immediate medical attention.

Uses of LEEVARIN 15 TABLET 10'S

  • Addressing methotrexate overdose and its associated toxicity, including strategies for management and mitigation.
  • Diminishing the counter effects of methotrexate, focusing on methods to alleviate or counteract its adverse reactions.
  • Management of Megaloblastic anemia, understanding its causes, symptoms, and appropriate treatment approaches.

Side Effects of LEEVARIN 15 TABLET 10'SArrow

Side effects are unwanted symptoms caused by medicines, but not everyone experiences them. LEEVARIN 15 TABLET 10'S can cause some common and serious side effects.

  • Diarrhea
  • Nausea
  • Vomiting
  • Inflamed and sore mouth
  • Tiredness
  • Allergic reactions

Safety Advice for LEEVARIN 15 TABLET 10'SArrow

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Pregnancy

CONSULT YOUR DOCTOR

There is a limited number of studies on the safety of LEEVARIN 15 TABLET 10'S during pregnancy, and it is unknown whether the medicine can be given during pregnancy. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.

Dosage of LEEVARIN 15 TABLET 10'SArrow

  • Your doctor will determine the appropriate dosage and duration of treatment with LEEVARIN 15 TABLET 10'S based on your specific medical condition, its severity, and other individual factors. It is crucial to adhere to your doctor's prescribed instructions precisely. Take the tablets exactly as directed.
  • To ensure optimal absorption and effectiveness, avoid breaking, crushing, or chewing the tablets. Instead, swallow each tablet whole with a full glass of water. This helps to deliver the medication properly into your system.
  • For the best therapeutic outcome, it is important to take LEEVARIN 15 TABLET 10'S at the same time every day. This helps maintain a consistent level of the medication in your body, maximizing its benefits. Consistency is key to managing your condition effectively. If you miss a dose, take it as soon as you remember, unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How to store LEEVARIN 15 TABLET 10'S?Arrow

  • Keep LEEVARIN 15MG TAB 1X10 away from the reach of children and pets.
  • Store LEEVARIN 15MG TAB 1X10 in a refrigerator (2 - 8°C). Do not freeze.

Benefits of LEEVARIN 15 TABLET 10'SArrow

  • Methotrexate works by inhibiting dihydrofolate reductase, an enzyme crucial for cell function, essentially acting as a folate antagonist. LEEVARIN 15 TABLET 10'S, on the other hand, is a folate derivative, meaning it's a form of folate that doesn't need to be processed by dihydrofolate reductase before the body can use it for DNA synthesis. This is a key difference in their mechanisms.
  • Interestingly, leucovorin can have a dual role when it comes to chemotherapy. While it protects healthy cells from the harmful effects of drugs like methotrexate, it can also boost the effectiveness (and toxicity) of other chemotherapy drugs like 5-fluorouracil. It does this by enhancing the binding of 5-fluorouracil within cancer cells, making the treatment more potent.
  • Therefore, LEEVARIN 15 TABLET 10'S is primarily used to rescue or protect normal cells from the adverse effects of methotrexate, particularly in high-dose regimens. By providing a readily usable form of folate, it allows these cells to continue vital processes like DNA synthesis even when methotrexate is present. This helps to reduce side effects such as bone marrow suppression and mucositis.
  • In essence, LEEVARIN 15 TABLET 10'S acts as a countermeasure to methotrexate's effects on healthy cells, ensuring that patients can tolerate the chemotherapy regimen better. This allows for potentially more aggressive and effective cancer treatment strategies.

How to use LEEVARIN 15 TABLET 10'SArrow

  • Your doctor will determine the appropriate dosage and treatment duration of LEEVARIN 15 TABLET 10'S based on your specific medical condition, its severity, and other relevant factors. It's crucial to adhere to your doctor's instructions regarding the medication's usage. This ensures that you receive the maximum benefit from the treatment.
  • Administer LEEVARIN 15 TABLET 10'S exactly as directed by your healthcare provider. Avoid altering the dosage or frequency of administration without consulting your doctor. Doing so can impact the medicine's effectiveness and may potentially lead to adverse effects.
  • To take LEEVARIN 15 TABLET 10'S, swallow the tablet whole with a full glass of water. Do not break, crush, or chew the tablet, as this can affect how the medication is absorbed into your system. Taking the tablet whole ensures that the medication is released gradually and consistently.
  • For optimal results, it's important to take LEEVARIN 15 TABLET 10'S at the same time every day. This helps maintain a consistent level of the medication in your body, which is essential for managing your condition effectively. Setting a daily reminder can help you adhere to your prescribed schedule.

FAQs

Why is LEEVARIN 15 TABLET 10'S given 24 hours after methotrexate?Arrow

LEEVARIN 15 TABLET 10'S is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.

Can LEEVARIN 15 TABLET 10'S cause swelling?Arrow

LEEVARIN 15 TABLET 10'S may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.

Can LEEVARIN 15 TABLET 10'S cause seizures?Arrow

There is no evidence that LEEVARIN 15 TABLET 10'S cause seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all the medicines that you are taking, including over-the-counter medications.

How long does it take for LEEVARIN 15 TABLET 10'S to work?Arrow

LEEVARIN 15 TABLET 10'S starts acting on the body within 20-30 minutes of oral intake. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with LEEVARIN 15 TABLET 10'S?Arrow

A healthcare professional will monitor you during the treatment with this medicine. Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor the alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

NULL interaction of LEEVARIN 15 TABLET 10'S with other drungsArrow

There are no known interactions of LEEVARIN 15 TABLET 10'S with other drugs.

Advice related to LEEVARIN 15 TABLET 10'SArrow

If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products. If you accidentally take too much LEEVARIN 15 TABLET 10'S, contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your doctor will regularly do lab tests to check the effectiveness of the medicine.

What molecule/combination is used for making LEEVARIN 15 TABLET 10'S?Arrow

LEUCOVORIN CALCIUM is the molecule/combination used for making LEEVARIN 15 TABLET 10'S.

For what ailments/diseases/conditions is LEEVARIN 15 TABLET 10'S prescribed?Arrow

LEEVARIN 15 TABLET 10'S is prescribed for ailments/diseases/conditions in Oncology.

References

Book Icon

Calcium Folinate 15mg Tablets - Summary of Product Characteristics (SmPC) [Internet]. (emc). 2020

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Marketer / Manufacturer Details

ADMAC LIFESCIENCES

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India

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LEEVARIN 15 TABLET 10'S

LEEVARIN 15 TABLET 10'S

MRP

₹

475

₹305

35.79 % OFF

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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